Selenium (Se) plays a catalytic, structural, and regulatory role in the body, which ensures the functioning of various biological systems and physiological and biochemical reactions. It mitigates oxidative stress and affects the efficiency of fatty acid biosynthesis in animal tissues. The aim of our study was to establish the relationship between the content of total lipids, lipid classes, and phospholipids in the blood plasma of rabbits when adding Se citrate to drinking water in different amounts. Rabbits in the control group received standard granulated feed and water without restriction. Rabbits of the 1st experimental group received daily selenium citrate in a dose of 50 μg Se per 1 kg of body weight with drinking water; of the 2nd group - 100 μg Se/kg; of the 3rd group - 200 μg Se/kg. The duration of the experiment was 30 days. The duration of the experiment was 30 days. In the blood plasma, the content of total lipids and the ratio of their classes and phospholipids were determined using generally accepted methods. A certain stimulating effect on the synthesis of lipids and different classes of lipids was established at a dose of 50 μg Se/kg of body weight. Se citrate in the used doses exhibited a dose-dependent biological effect in the body of rabbits when administered for 15 and 30 days. Changes in the lipid composition of the blood plasma of rabbits were detected when using different doses of Se citrate, which may be a consequence of their multifactorial effect on the structure and function of individual tissues and organs. This is also indicated by a certain shift in the spectrum of phospholipid fractions towards an increase in the content of poorly oxidizable ones (lysophosphatidylcholine and sphingomyelin) with a decrease in easily oxidizable ones (phosphatidylcholine) in different experimental groups of rabbits, which may indicate the stabilization of compensatory mechanisms for supporting cell membranes.