Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv; e-mail: moiseyenkoev@gmail.com The purpose of the study was to determine the functional changes in cardiohemodynamics during dosed physical activity of a person in the conditions of sea storm kinetosis and features of cerebral biorhythms, this may indicate the development of modification rearrangements of the mechanisms of central regulation of the body’s functional systems. The research was carried out with the participation of 23 specialists of the Antarctic expedition (men aged 24 to 45 years). They crossed the Drake Passage by sea: sea turbulence - 7 points, the ship’s roll angle - 120, the duration of the crossing was 4 days. It was determined that a person’s stay in the conditions of a sea wave leads to changes in the mechanisms of vasoconstrictor regulation, this was indicated by inadequate blood pressure fluctuations during functional diagnostics and an increase in the load on the heart’s activity due to an increase in pulse and diastolic pressure and the lack of recovery dynamics after performing physical work. It was shown that as a result of marine kinetosis in the structure of cerebral biorhythms, the power of β1 and β2 rhythms in the projections of the cerebral cortex increases. Such changes may indicate a certain participation of central mechanisms in the reorganization of the regulation of functional reserves of cardiohemodynamics. It is assumed that when using medical devices for patients with a cardiac profile in conditions of seasickness, it is advisable to take into account the presence of features of changes in the central and regional regulation of blood circulation function.