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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2024; 70(1): 14-20


NORADRENERGIC INFLUENCE ON TONIC FIRING IN TRIGEMINAL GANGLION NEURONS

M.V. Telka, V.Yu. Maslov, M.S. Veselovsky, S.A. Fedulova

    Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz70.01.014


Abstract

Adrenoreceptors play a key role in sympathetic influences on sensory neurons in normal and neuropathic conditions. We studied noradrenaline action on tonic firing in cultured rat trigeminal ganglion neurons. In a majority of the neurons (68%), Noradrenaline application had no marked effect on the firing properties. The rest of the cells (32%) were highly sensitive to noradrenaline action; they lost the ability to tonic firing and single action potential parameters significantly changed. It was established that NA-induced action on the firing is mainly due to the activation kinetics slowing of voltage-gated calcium channels. The data suggest a possibility of differential sympatho-sensory interaction in the trigeminal pathways.

Keywords: trigeminal ganglion; noradrenaline; tonic firing; voltage-gated calcium channels.

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