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NORADRENERGIC INFLUENCE ON TONIC FIRING IN TRIGEMINAL GANGLION NEURONS
M.V. Telka, V.Yu. Maslov, M.S. Veselovsky, S.A. Fedulova
Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz70.01.014
Abstract
Adrenoreceptors play a key role in sympathetic influences
on sensory neurons in normal and neuropathic conditions.
We studied noradrenaline action on tonic firing in cultured
rat trigeminal ganglion neurons. In a majority of the neurons
(68%), Noradrenaline application had no marked effect on the
firing properties. The rest of the cells (32%) were highly sensitive to noradrenaline action; they lost the ability to tonic firing
and single action potential parameters significantly changed.
It was established that NA-induced action on the firing is
mainly due to the activation kinetics slowing of voltage-gated
calcium channels. The data suggest a possibility of differential
sympatho-sensory interaction in the trigeminal pathways.
Keywords:
trigeminal ganglion; noradrenaline; tonic firing; voltage-gated calcium channels.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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