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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2024; 70(1): 14-20

NORADRENERGIC INFLUENCE ON TONIC FIRING IN TRIGEMINAL GANGLION NEURONS

M.V. Telka, V.Yu. Maslov, M.S. Veselovsky, S.A. Fedulova

    Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz70.01.014


Abstract

Adrenoreceptors play a key role in sympathetic influences on sensory neurons in normal and neuropathic conditions. We studied noradrenaline action on tonic firing in cultured rat trigeminal ganglion neurons. In a majority of the neurons (68%), Noradrenaline application had no marked effect on the firing properties. The rest of the cells (32%) were highly sensitive to noradrenaline action; they lost the ability to tonic firing and single action potential parameters significantly changed. It was established that NA-induced action on the firing is mainly due to the activation kinetics slowing of voltage-gated calcium channels. The data suggest a possibility of differential sympatho-sensory interaction in the trigeminal pathways.

Keywords: trigeminal ganglion; noradrenaline; tonic firing; voltage-gated calcium channels.

Full text: (PDF, in Ukrainian)

References

  1. Alles SRA, Smith PA. Peripheral voltage-gated cation channels in neuropathic pain and their potential as therapeutic targets. Front Pain Res (Lausanne). 2021, 2:750583. CrossRef PubMed PubMedCentral
  2. Matthews B, Robinson PP. The course of post-ganglionic sympathetic fibres distributed with the trigeminal nerve in the cat. J Physiol. 1980;303:391-401. CrossRef PubMed PubMedCentral
  3. Kummer W, Gibbins IL, Stefan P, Kapoor V. Catecholamines and catecholamine-synthesizing enzymes in guinea-pig sensory ganglia. Cell Tissue Res. 1990;261(3):595-606. CrossRef PubMed
  4. Telka MV, Maslov VYu, Veselovsky NS, Fedulova SA. Noradrenaline action on electrical activity of cultured trigeminal ganglion neurons. Fiziol Zh. 2019 65(6): 22-9. CrossRef
  5. Abdulla FA, Smith PA. Ectopic alpha2-adrenoceptors couple to N-type Ca2+ channels in axotomized rat sensory neurons. J Neurosci. 1997;17(5):1633-41. CrossRef PubMed PubMedCentral
  6. Honma Y, Yamakage M, Ninomiya T. Effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of dorsal root ganglion neurons in a neuropathic pain model. Brain Res. 1999;832(1-2):195-206. CrossRef PubMed
  7. Takeda M, Ikeda M, Tanimoto T, Lipski J, Matsumoto S. Changes of the excitability of rat trigeminal root ganglion neurons evoked by alpha(2)-adrenoreceptors. Neuroscience. 2002;115(3):731-41. CrossRef PubMed
  8. Dolphin AC. G protein modulation of voltage-gated calcium channels. Pharmacol Rev. 2003;55(4):607-27. CrossRef PubMed
  9. Currie KP. G protein modulation of CaV2 voltage-gated calcium channels. Channels (Austin). 2010;4(6):497-509. CrossRef PubMed PubMedCentral
  10. Telka MV, Rikhalsky OV, Veselovsky NS. Excitability properties of trigeminal ganglion neurons. Fiziol Zh. 2016; 62(2): 24-34. CrossRef PubMed
  11. Veselovsky NS, Engert F, Lux HD. Fast local superfusion technique. Pflügers Arch: Eur J Physiol. 1996;432(2):351-4. CrossRef PubMed
  12. Telka MV, Maslov VYu, Veselovsky NS, Fedulova SA. Tel'ka M.V. Adrenergic modulation of high-threshold voltage-gated calcium channels in trigeminal ganglion neurones. Fiziol Zh. 2020 065(1):75-82. CrossRef
  13. M. Telka, V. Maslov, S. Fedulova. Changes of the excitability of trigeminal ganglion neurons under noradrenergic modulation of calcium currents. Eur Neuropsychopharmacol. 44 (2021) S13-4. CrossRef
  14. Strock J, Diverse-Pierluissi MA. Ca2+ channels as integrators of G protein-mediated signaling in neurons. Mol Pharmacol. 2004;66(5):1071-6. CrossRef PubMed
  15. Tedford HW, Zamponi GW. Direct G protein modulation of Cav2 calcium channels. Pharmacol Rev. 2006;58(4):837-62. CrossRef PubMed
  16. Dolphin AC. A short history of voltage-gated calcium channels. Br J Pharmacol. 2006;147 Suppl 1: 56-62. CrossRef PubMed PubMedCentral
  17. Li C, Horn JP. Differential Inhibition of Ca2+ channels by alpha2-adrenoceptors in three functional subclasses of rat sympathetic neurons. J Neurophysiol. 2008;100(6):3055-63. CrossRef PubMed PubMedCentral
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