The results of dynamic examination of the dental status, the Analgesia Nociception Index (ANI), the content of hydrogen sulfide (H2S) and the indicators of nitric oxide metabolism (NO) in the oral fluid under conditions of dentitions correction are presented in the article. The evaluation of nociception/ antinociception balance was performed by using ANI-Monitor apparatus (MetroDolores, France). Patients without concomitant pathology with partial loss of teeth under conditions of defects compensation with bridging and partial removable prostheses (primary and re-prosthetics), with complete loss of dentition with correction with complete removable prostheses (primary and re-prosthetics) were examined. The examination was performed before prosthesis and also after 24 h, on the 7th and 30th day after dentition correction. It was established that in the structure of periodontal tissue morbidity at a young age the gingivitis was predominant, in some cases generalized periodontitis of varying severity, the periodontal disease was often revealed with the age. In examined persons who used prostheses the signs of trauma of the prosthetic bed mucosa was observed. It was found that ANI values depend on the state of oral mucosa. The most pronounced changes of the index were established after the primary prosthesis and under the condition of correction of the dentition with complete removable laminar prostheses. In such patients, the adaptation processes were the longest (to 30 days) and were accompanied by a steady increase of H2S, sum of NO metabolites (NO2 - + NO3 - ) and peroxynitrite contents in the oral fluid. Thus, the dynamics of changes in ANI and H2S content in the oral fluid reflects the course of adaptive-compensatory reactions after the conditions of dentitions correction of dental rows. Indicators of accelerated metabolism of NO (peroxynitrite, sum of NO2 - + NO3 - ) can be regarded as predictors of disorders of dental status, which allow to estimate the probability of pain and formation of trophic disorders in preclinical stages of disorders. The ANI value reflects the degree of nociception and may act as a marker of adaptation to prostheses.