We studied changes in the amount and the ratio between various subclasses of T-lymphocytes in 25 basketball athletes (qualification of MS and MSIC, 28.2 ± 5.3 years old) and 60 persons (27.8 ± 5.1 years old) who before participating in the study did not play sports and have a sedentary lifestyle. The amount of different subclasses of T-lymphocytes was measured in all the participants. Blood sampling was performed before the start of the study and in 2 months. All the participants were divided into four groups: groups II and IV were trained for 2 months according to the author’s technique of power fitness. As a result of the proposed physical activity, an increase in the amount of T-helpers in the blood of group IV athletes was found as well as an improvement in the immunoregulatory index. The proposed power fitness technique had a positive effect on the immunity indicators of people who have not been previously involved in sports. For this numerous category a longer period of continuous sports activities can be recommended.