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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(1): 75-82


CHARACTERISTICS OF WAKE-SLEEP CYCLE ORGANIZATION UNDER ALZHEIMER’S DISEASE MODELING IN RATS

V.V. Geyko, O.G. Berchenko, N.A. Levicheva, V.V. Sokolik

    SI «Institute of Neurology, Psychiatry and Narcology of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine
DOI: https://doi.org/10.15407/fz66.01.075

Abstract

The features of sleep organization in the dynamics of neurodegenerative pathology in rats under Alzheimer’s disease (AD) modeling were the aim of study of the neurophysiological mechanisms of early manifestations of AD. It was shown that developing of experimental AD can be characterized by neurophysiological features of sleep: inhibition of REM stage representation combined with prolongation of its latent period and reduction of its first episode duration; substantial reduction of deep slow-wave stage representation; dominance of incomplete cycles of sleep. It is concluded that the obtained data may be useful for the early diagnostics of AD and the development of approaches to AD correction.

Keywords: wake-sleep cycle; sleep phases; β-amyloid peptide; model of Alzheimer’s disease.

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