FEATURES OF MEMORY DISORDERS IN THE EARLY STAGES OF ALZHEIMER’S DISEASE IN THE RATS
D.O. Bevziuk, N.O. Levicheva, V.V. Sokolik
SI, Institute of Neurology, Psychiatry and Narcology of the NAMS of Ukraine, Kharkiv, Ukraine
DOI: https://doi.org/10.15407/fz66.01.068
Abstract
Neuroethological studies of working and long-term (emotional)
memory were conducted on 15 male rats aged 15–16
months with the Alzheimer’s disease model induced by a
single intrahippocampal injection of 15 nmol/l of β-amyloid
peptide 40 aggregates. The control group included 5 intact
rats, representative by age and sex. The concentration of endogenous
β-amyloid peptide 42 was studied in separate brain
structures (neocortex, hippocampus, olfactory bulbs, and olfactory
tubercles) using the immunoassay. It has been found that
an increase in the content of endogenous β-amyloid peptide
42 by 27% in the hippocampus caused a decrease in working
memory, namely, violation of the differentiation of the shape
of objects and forgetting the familiar object. It has been shown
that an increase of signal reactions in 2,2 times and a decrease
of extrasignal reactions in 1,7 times while maintaining the
proportion of positive conditioned reflex responses against the
background of an increased level of anxiety are indicators of
early manifestations of impaired long-term emotional memory.
Keywords:
memory; Alzheimer’s disease; rats; β-amyloid peptide
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