FEATURES OF MEMORY DISORDERS IN THE EARLY STAGES OF ALZHEIMER’S DISEASE IN THE RATS
D.O. Bevziuk, N.O. Levicheva, V.V. Sokolik
SI, Institute of Neurology, Psychiatry and Narcology of the NAMS of Ukraine, Kharkiv, Ukraine
Neuroethological studies of working and long-term (emotional)
memory were conducted on 15 male rats aged 15–16
months with the Alzheimer’s disease model induced by a
single intrahippocampal injection of 15 nmol/l of β-amyloid
peptide 40 aggregates. The control group included 5 intact
rats, representative by age and sex. The concentration of endogenous
β-amyloid peptide 42 was studied in separate brain
structures (neocortex, hippocampus, olfactory bulbs, and olfactory
tubercles) using the immunoassay. It has been found that
an increase in the content of endogenous β-amyloid peptide
42 by 27% in the hippocampus caused a decrease in working
memory, namely, violation of the differentiation of the shape
of objects and forgetting the familiar object. It has been shown
that an increase of signal reactions in 2,2 times and a decrease
of extrasignal reactions in 1,7 times while maintaining the
proportion of positive conditioned reflex responses against the
background of an increased level of anxiety are indicators of
early manifestations of impaired long-term emotional memory.
memory; Alzheimer’s disease; rats; β-amyloid peptide
- Purdenko TI. The problem of cognitive impairment in neurological practice (reference review). Buk Med Herald. 2014;18; 4:216-21. [Ukrainian].
- Ciobica A, Lefter R, Stoica B. The interactions between the cholinergic and catecholaminergic systems focusing on memory and oxidative stress. Fiziol J. 2017;63;2:25-33.
- Huijgen J, Samson S. The hippocampus: a central node in a large-scale brain network for memory. Rev Neurol (Paris). 2015;171:204-16.
- Insel N, Takehara-Nishiuchi K. The cortical structure of consolidated memory: a hypothesis on the role of the cingulate-entorhinal cortical connection. Neurobiol Learn Mem. 2013;106:343-50.
- Querfurth H, Ferla F. Alzheimer's disease. New Engl J. 2010;362:329-44.
- Sadigh-Eteghad S, Sabermarouf B, Majdi A. Amyloidbeta: a crucial factor in Alzheimer's disease. Med Princ Pract. 2015;24:1-10.
- Heneka MT, Carson J, Khoury JE, et al. Neuroinflammation in Alzheimer's disease. Lancet. 2015;14:388-405.
- Iptyshev AM, Gorina YaV, Lopatina OL, et al. Experimental models of Alzheimer's disease: advantages and disadvantages. Sib Med Rev. 2016;4:1-17. [Russian].
- Kolobov VV, Storozheva ZI. Modern pharmacological models of Alzheimer's disease. Exp Neurol. 2014;8:38-4. [Russian].
- Stepanichev MYu, Ivanov AD, Lazareva NA, Moiseeva YuV, Gulyaeva NV. Neurodegenerative changes induced by injection of ß-amyloid peptide fragment (25-35) in hippocampus are associated with NGF-signalling activation. Bull RSMU. 2016;1:14-9. [Russian].
- Lobzin SV, Sokolova MG, Nalkin SA. Influence of brain basal cholinergic system dysfunction on the condition of cognitive functions (literature review). North-Western State Med Univ. 2017;9:53-8. [Russian].
- Mukhin V. Pathogenesis of the basal forebrain cholinergic dysfunction in Alzheimer's disease. Sechenov Russ Physiol J. 2013; 99:793-804. [Russian].
- Bures J, Petranov M, Zahar I. Electrophysiological methods. Translation from Polish. Moscow: Publishing house of foreign literature. 1962. [Russian].
- Tzyy-Nan H, Yi-Ping H. Novel object recognition for studying memory in mice. Neuroscience. 2014;4:1-7.
- Dubrovina NI,, Ranneva SV,, Khrapova MV,, Lipina TV. Deficit of the passive avoidance learning in calsyntenin-2-deficient mice. Russ Physiol J. 2017;10:1114-24. [Russian].
- Bevzuyk DA. Neurophysiological mechanisms of recovery of trace processes in rats under influence of cerebral and distant neurotransplantation of the locus coeruleus tissue of the embryonic brain. Disser … PhD in biological sciences: 03.00.13. Kharkiv. 2001: 159. [Ukrainian].
- Sokolik VV, Berchenko OG, Shulga SM. Comparative analysis of nasal therapy of curcumin soluble and liposomal forms of rats with model of Alzheimer's disease. J. Alzheimer's Dis Parkinson. 2017;7:2-6.
- Rasoolijazi H, Azad N, Joghataei MT, et al. The protective role of carnosic acid against beta-amyloid toxicity in rats. Sci World J. 2013; Article ID 917082:1-5.
- SoheiliM, Tavirani MR, Salami M. Clearance of amyloid beta plaques from brain of Alzheimeric rats by Lavandula angustifolia. Neurosci Med. 2012;3, Article ID 26193:1-6.