The dynamics of individual biochemical parameters in blood serum of 72 white rats with active and passive type of behavior under the combined effects of immobilizing stress and cadmium during 30 days was investigated. The type of behavior was determined using the open field test. The combined effect of factors was simulated by the daily injection into the stomach of an aqueous solution of cadmium sulfate followed by keeping animals in separate plastic boxes for 6 h. Multidirectional changes in the concentration of calcium were revealed – an increase up to 10 days of experiments, subsequently – a decrease of the concentration of calcium in both groups of the animals, at the end of experiments – in the passive ones by 43.8%, in the active ones – by 28.1%; an increase of glucose concentration in active animals in the range of 10.0-29.7%, in the passive ones – in the range of 13.0-38.0%, hypercholesterolemia with a tendency to decrease the concentration of total cholesterol at the end of the experiments in the active animals and an increase in the passive ones compared with the previous terms of observation. Alkaline phosphatase activity was increased at the beginning of the experiment, there was a decrease of enzyme activity on the 10th day in passive animals and on the 30th days in both groups, especially in the passive group – by 45.5%. The activity of aminotransferases increased from the 5th day and at the end of the experiment, the activity of alanineaminotransferase in passive animals was higher by 48.7%, in the active ones – by 31.9% compared to the control. Metabolic changes occur as a result of a combination of nonspecific effects of immobilization stress and direct toxic effects of cadmium on an organism. Intensity and orientation of the studied indicators depend on the individual and typological features of the CNS. More pronounced changes were observed in passive animals.