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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(1): 18-24


I.F. Labunets

    State Institute of Genetic and Regenerative Medicine,National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine


Behavior of FVB/N and 129/Sv mice (male and female, 6-7 months old) was evaluated using the open-field test, the rotarod test and test on muscle rigidity two weeks after neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. MPTP was administered according to the schemes reproducing various phases/stages of parkinsonism in mice: 12 mg/kg 4 times in 2 h (group I) and 30 mg/kg once (group II). A decrease in the number of vertical rears and step length comparing to the control (solvent) was observed in the male and female FVB/N mice of group I, while the changes in the number of crossed squares was dependent on sex. In the males of group II there was a decrease in the number of vertical rears and an increase in the number of boluses and the retention time on the shaft. Against the background of an increase in the number of crossed squares and retention time on the shaft, the females of this group displayed a decrease in the number of vertical rears, explored holes and boluses by 2, 1.5 and 4 times, respectively. The 129/Sv males of group I experienced a decrease in the number of vertical rears and step length and an increase in the retention time on the shaft. In the female the number of crossed squares, vertical rears, explored holes and step length decreased by 2.5, 11.3, 28, and 1.3 times, respectively. The males of group II showed a decrease in the number of vertical rears, explored holes and step length and an increase in the number of boluses. The females displayed similar behavioral changes to the group I. Thus, locomotor and non-motor behavioral disorders as well as their combinations were mainly dependent on the MPTP administration schemes, mouse genotype and sex.

Keywords: parkinsonism; MPTP; behavior; mice of different strains; sex.


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