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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2020; 66(1): 3-9


Neuroprotective effects of a new nootropic agent Mitochondrin-2

K.A. Dronska1, M.V. Vitushynska1, Y.I. Chernyk1, A.N. Makarenko2, N.P. Matiytsiv1

  1. Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, Lviv, Ukraine
  2. Department of Psychology, Interregional Academy of Personnel Management, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz66.01.003

Abstract

Since neurodegenerative diseases are incurable, it is important to study experimental neuroprotective preparation on model organisms. In this work, we studied the neuropeptide Mitochondrin-2 (M-2) effect on Drosophila neurodegenerative models of brain pathology induced by functional knockdown of swiss cheese (sws) and Superoxide dismutase 1 (Sod-1) genes in gliocytes. We found that, after using M-2, brain zone degeneration decreased and markers of oxidative stress (conjugates diene CD and thiobarbituric acid reactive substances TBARS) reached the control level. However, we did not observe any improvement in life span or locomotor activity. This suggests a certain neurotrophic and antioxidant effect of M-2, especially for glial cells, but its effect on the protection of neurons function remains unclear. Further research is needed for effect mechanism of peptide neuroprotectors.

Keywords: Drosophila melanogaster; neurodegeneration; swiss cheese gene; Sod-1 gene; neuropeptides

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