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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(6): 3-11


ANDROGENIC FUNCTION OF TESTES AND STATE OF SPERMS IN YOUNG AND AGING RATS AFTER LONG INHIBITION OF STEROID AROMATASE FOLLOWED BY ITS WITHDRAWAL

L.I. Polyakova, O.V. Sachynska, O.A. Faliush, A.G. Reznikov

    V.P. Komisarenko Institute of Endocrinology and Metabolism of NAMS Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.06.003

Abstract

Effects of letrozole, a steroid aromatase inhibitor, administration (1 mg/kg b.w. every two days for 3 months) and withdrawal in the blood plasma testosterone level and quantity, morphology and quality of epididymal sperms were studied in young (8 months) and aging (18 months) Wistar male rats. Changes of the features under study occurred prevalently in aging animals. Inhibition of testosterone to estradiol conversion resulted in stimulation of spermatogenesis, an increase of sperm quantity in epididymis and an improvement of sperm quality composition and respiration. In 2 months after letrozole withdrawal, there was no difference between experimental and control groups with regard to testosterone level, sperm quantity and respiration, and percentage of normal morphological forms.

Keywords: testosterone, letrozole, sperm, rat

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