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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(3): 7-11


PHARMACOLOGICAL BLOCKADE OF PROTEASE-ACTIVATED RECEPTORS 1 NORMALIZES BEHAVIORAL HYPEREXCITABILITY OF RATS IN THE LATENT STAGE OF THE EXPERIMENTAL MODEL OF TEMPORAL LOBE EPILEPSY

M. Semenikhina, R. Bogovik, M. Fedoryuk, О. Lunko, A Savotchenko, E. Isaeva

    Bohomoletz Institute of Physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz65.03.007

Abstract

Temporal lobe epilepsy (TLE) leads to variety of neuropsychological comorbidities, which may have severe impact on social and emotional well-being and significantly reduce the overall quality of life. In the present study, we demonstrate the effect of blocking protease-activated receptor 1 (PAR1), the main thrombin receptor in the central nervous system, on hyperexcitability in the early stages of epilepsy formation. We showed that inhibition of PAR1 leads to the normalization of behavioral hyperexcitability of rats in the latent stage of temporal lobe epilepsy in the lithium-pilocarpine model of status epilepticus (SE) (in the pick-up test which is considered as the most sensitive among tests used in the work: 2.4 ± 0.3 points compared to 3.5 ± 0.58 points for the group after SE). The obtained results correlate with previous studies of the effect of PAR1 inhibition on animal behavior using pharmacological approach and in animals with PAR1 knockout, and provide a further evidence of the role PAR1 in the modulation of affective behavior in TLE.

Keywords: protease-activated receptors 1; lithium-pilocarpine model; status epilepticus; emotional excitability.

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