Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(1): 3-8


Release of a factor aftermyocardial ischemia during reperfusion - the investigation of its influence onmyocardium, coronary and peripheral vessels

V.F. Sagach A.V. Dmitrieva T.V. Shimanskaya S.M. Nadtochiy

    A.A. Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev


Abstract

The effect of reoxygenated coronary effluent of an isolated guinea-pig heart on a sequentially perfused second heart, right auricle trabecula and arterial vessel rings was studied after 20 min ischaemia of the first heart. It has been shown that a factor released after myocardial ischemia/reperfusion stimulates arrhythmia, decreases myocardial contractility of the second heart and depresses tonical tension of the right auricle trabecula and arterial vessel rings. Storage of the coronary effluent up to 24 h did not modify its effects. These results suggest stable factor released from an isolated heart after ischaemia at reperfusion to exert humoral effect not only on a myocardial contractility and coronary circulation but on the peripheral vessels tonus.

References

  1. Жукова А. В. Модулюючий вплив ендотеліального релаксуючого фактора на реактивність міокарда та артеріальних судинних смужок //Фізіол. журн. - 1999. - 45, № 1-2. - С. 64-72.
  2. Мойбенко А.А., Сагач В.Ф. О гуморальном механизме реакций емкостных сосудов при иммунном и гипоксическом воздействии на сердце //Физиол.журн. СССР. - 1981. - LXVII, № 1. -С.73-80.
  3. Мойбенко А.А., Сагач В.Ф. Иммуногенные нарушения деятельности сердечно-сосудистой системы. - К.: Наук.думка, 1992. - 302 с.
  4. Сагач В.Ф., Дмитриева А.В. Кардио- и гемоди-намика у собак при развитии постишемической шоковой реакции // Физиол.журн. - 1989. -35,N 4. - С. 9-15
  5. Сагач В.Ф., Шиманська Т.В., Надточій С.М.Вивчення ролі оксиду азоту у змінах споживання кисню та кисневої вартості роботи серцевого м”яза // Там само. - 2000. – 46, №2. -С.33-38.
  6. Ткачеко Б.И., Поленов С.А., Агнаев А.К. Кардиоваскулярные рефлексы. – Л. Медицина, 1975. -232 с.
  7. Bolli R. Postischemic myocardial stanning. Pathogenesis, pathophysiology and clinical relevance. In: Myocardial protection: the pathophysiology ofreperfusion and reperfusion injury. - New York:Raven Press, 1992. - P. 105-149
  8. Felix S.B., Stangl V., Frank T.M. et al. Release ofa stable cardiodepresant mediator after myocardialischemia during reperfusion // Cardiovasc. Res. -1997. - 35. - P. 68-79.
  9. 9. Felix S.B., Stangl V., Pietsch P. et al. Soluble substances released from postischemic reperfused hearts reduce calcium transient and contractility by blocking the L-type calcium channel // J.Amer. Coll. Cardiol. - 2001. - 37, N 2. - P. 668-675.
  10. 10. Lefer A.M. Significance of lipid mediators in shock states // Circ. Shock. - 1989. - 27. - P. 3-12.
  11. Neely J. R., Liebermeister H., Battersby E. J. et al. Effect of pressure development on oxygen consumption by isolated heart // Amer. J. Physiol. -1967. - 221. - P.804-813.
  12. Reimer K.A., Tanaka M., Murray C.E. et al.Evaluation of free radical injury in myocardium// Toxicol. Pathol. - 1990. - 18. - P. 470-480.
  13. Stangl V., Baumann G., Stangl K., Felix S.B.Negative inotropic mediators released from the heart after myocardial ischemia-reperfusion //Cardiovasc. Res. - 2002. - 53, N 1. - P. 12-30.
  14. Zhukova А.V., Sagach V.F. Role of eicosanoids in the postischemic shock development // Pol. J.Pharmacol. - 1996. - 48, N 1. - P. 23-29.
  15. Zhao-Kang Y, N.J.Draper, A.M.Shah. Са 2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts // Amer.J.Physiol. - 1999. - 276. - P.H623-H632.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.