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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2019; 65(1): 81-85


THE INFLUENCE OF THE QUERCETIN AND THE TRIOVIT ON THE STATE OF THE RAT’S SMALL INTESTINE WITH INFLAMMATION INDUCED BY CARRAGEENAN AGAINST A BACKGROUND OF MELATONIN DEFICIENCY

Y.M. Anasevych, V.S. Cherno

    Mykolaiv V.O. Sukhomlynskyi National University, Ukraine
DOI: https://doi.org/10.15407/fz65.01.081

Abstract

The state of the pro- and antioxidant system of the small intestine of rats during inflammation was studied against the background of a lack of melatonin. Reduced antioxidant protection was established under these conditions: the activity of superoxide dismutase decreased by 38% and catalase by 34%. This observation suggests that hypomelatoninemia increases the negative effects of inflammation in the small intestine. The introduction of triovite and quercetin in the diet of the rat having inflammation, against the background of the lack of melatonin, reduces the content of malondialdehyde by 22% and increases the activity of catalase by 23%, which suggests an increasie in the antioxidant defense and reduction in the negative effects of inflammation in the small intestine. The study indicates a positive effect of triovite and quercetin on an inflammatory condition in the small intestine of rats.

Keywords: small intestine; melatonin; hipomelatoninemia; quercetin; triovit; inflammation; carageenan

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