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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(6): 10-14


Effects of no donor sin-1 on rats cardiac sarcoplasmic reticulum calcium transport

O.YU.Garmatina, V.I.Azarov, A.A.Moibenko

    A.A.Bogomolets Institute of Physiology, NationalAcademy of Sciences of Ukraine, Kiev


Abstract

The effects of non-enzymatic disintegration of SIN- 1 products (nitric oxide, superoxide anion and peroxynitrite) on Са2+-transport of sarcoplasmic reticulum were studied on homogenates of rats myo- cardium. It was shown that SIN-1 (30 µM) exerts a significant activating effect on ryanodine-sen- sitive calcium channels resulted in three-fold in- crease of Са2+ release rate via these channels. Such effect of SIN-1 realized mainly by nitric oxide effect and, partially, superoxide radical. SIN-1 did not еffect the Са2+ -ATPase activity of sarcoplasmic reticulum

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