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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(6): 47-52


SYSTEMIC TOXIC ACTION OF DENTAL SEALANTS ON NERVOUS TISSUE IN THE CONDITION OF THEIR DIRECT INFLUENCE IN VITRO

O.A. Znachkova1, I.V. Lushnikova2, G.G. Skibo2, M.Y. Antonenko1, N.V. Voitenko2

  1. Bogomolets National Medical University, Ukraine
  2. Bogomoletz Institute of Physiology NASU, Ukraine
DOI: https://doi.org/10.15407/fz63.06.047

Abstract

Here we present the results of in vitro studies of the direct effect of various dental sealants on cultured hippocampus slices. According to the results of the study, the materials can be divided in two groups - with the minimum toxic effect (resin nails, AH-Plus and acroseal), and with pronounced neurotoxic effects (RealSeal and foredent). By the degree of toxicity, the test materials can be distributed as follows: resin pins<AHPlus<acroseal<RealSeal<foredent. The results of the work can be used as recommendations for dentists to choose the dental sealants according to their neurotoxic properties to prevent unwanted complications.

Keywords: Dental sealants, cytotoxic effect, cultured sections of the hippocampus

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