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Changes in the total calcium content and in the activity of alkaline phosphatase and gamma-glutamyltransferase in the blood serum of rats with Mönckeberg's experimental arteriosclerosis
Holdobina OV
Department of Pathophysiology, O. O. Bogomolets National Medical University, Kiev
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Abstract
Experiments on rats (single-action, six-days' hyperepinephrinemia and monoiodacetatic acid intoxication) were performed to study the calcium concentration, alkaline phosphatase and gamma-glutamyltransferase activities in serum at Monckeberg's medial calcific sclerosis modelment. It is established reduction serum level of calcium in an hour past single-acting hyperepinephrinemia, increase it's level after six-days'-monoiodacetatic intoxication, increase of "serum alkaline phosphatase activity/gamma-glutamyltransferase activity" (as indirect evidences the bone isozyme of alkaline phosphatase and parathyroid hormone activity increase) after six-days' hyperepinephrinemia and monoiodacetatic acid intoxication. Probably, these changes in serum calcium metabolism and system it's regulation may play pathogenetic role in early period Mönckeberg's arteriosclerosogenesis.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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