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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 1998; 44(1-2): 71-76

Changes in the total calcium content and in the activity of alkaline phosphatase and gamma-glutamyltransferase in the blood serum of rats with Mönckeberg's experimental arteriosclerosis

Holdobina OV

    Department of Pathophysiology, O. O. Bogomolets National Medical University, Kiev


Experiments on rats (single-action, six-days' hyperepinephrinemia and monoiodacetatic acid intoxication) were performed to study the calcium concentration, alkaline phosphatase and gamma-glutamyltransferase activities in serum at Monckeberg's medial calcific sclerosis modelment. It is established reduction serum level of calcium in an hour past single-acting hyperepinephrinemia, increase it's level after six-days'-monoiodacetatic intoxication, increase of "serum alkaline phosphatase activity/gamma-glutamyltransferase activity" (as indirect evidences the bone isozyme of alkaline phosphatase and parathyroid hormone activity increase) after six-days' hyperepinephrinemia and monoiodacetatic acid intoxication. Probably, these changes in serum calcium metabolism and system it's regulation may play pathogenetic role in early period Mönckeberg's arteriosclerosogenesis.


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