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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(5): 63-68


The influence of ozone and toxic airborne particulate matter on airways in mice

T.U. Gots

    P.L. Shupik Medical Academy for PostgraduateTraining, Kiev


Abstract

We tested the hypothesis that exposures to particulate matter and ozone can produce asthma-like symptoms. Balb/c mice received a single intratracheal instillation of particulate matter and TiO2 or they were exposed to low concentration of ozone. We have established that exposure to particulate matter produces increased responsiveness to methacholine in mice. Exposure to ozone and TiO2 did not produce changes in respiratory mechanics. These data are spreading our understanding about mechanisms of environmental influence on air- ways.

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