Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2017; 63(1): 91-94

CHANGES OF LIFETIME MORPHOLOGICAL PARAMETERS OF THE RETINA ON THE BACKGROUND OF CORRECTION OF LIPID METABOLISM IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

N.N. Veselovskaya

    Kyiv Medical University UAFM; Kyiv City Eye Center, KCH №1.
DOI: https://doi.org/10.15407/fz63.01.091


Abstract

The functional changes of retina morphological parameters of macular zone were investigated under condition of long term action of fenofibrate, 145 mg in patients with diabetes mellitus type 2. Dynamic observation of certain ophthalmologic (visual acuity, macular thickness zone) and system functional parameters (lipid fractions content in serum) in long-term use of this medical drug in 20 patients with diabetes type 2 and DMO for 8 months. In this period we revealed some positive changes in the functional state of the macular area: increase of visual acuity, decrease of macula thickness and the improvement of the lipid profile in blood serum.

Keywords: diabetes; macular edema; blood lipid fractions.

Full text: (PDF, in Ukrainian)

References

  1. Balashevich LI, Izmaylov AS, Brzheskiy VV. Ocular manifestations of diabetes. Saint Petersburg, MAPO, 2004; 123. [Russian].
    2.  
  2. Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin epidemiologic study of Diabetic Retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type I diabetes. Ophthalmology. 1998; (105): 1801. CrossRef  
  3. Chaturvedi N, Sjolie AK., Stephenson JM, Abrahamian H, Keipes M, Castellarin A, Rogulja-Pepeonik Z, Fuller JH. Effect of lisinopril on progression of retinopathy in normotensive people with type I diabetes. The EUCLID Study Group. EURODIAB Controlled Trial of Lisinopril in Insulin Dependent Diabetes Mellitus. Lancet. 1998; (351): 28. CrossRef  
  4. UK Prospective Diabetes Study Group. UK Prospective Diabetes Study. XII: Differences between Asian, AfroCaribbean and white Caucasian type 2 diabetic patients at diagnosis of diabetes. Diabetes Medicine. 1994; (11): 670.
    5.  
  5. Arbeneva NS, Patrina VV, Bratko GV, Chernykh VV, Sazonova OV. Experience of micronized fenofibrate in the proliferative diabetic retinopathy. Bulletin of the Novosibirsk State University. 2011; (4): 11‒14. [Russian].
    6.  
  6. Veselovska NM. Risk factors for vascular pathology of eye in patients with diabetes. Clinical Endocrinology and Endocrine Surgery. 2013; (1): 42. [Ukrainian].
    7.  
  7. Stephenson JM, Fuller JH, Viberti GC, Sjolie AK. Blood pressure, retinopathy and urinary albumin excretion in IDDM: the EURODIAB IDDM Complications Study. Diabetologia. 1995; (38): 599. CrossRef PubMed
    8.  
  8. Klein BE, Moss SE, Klein R, Surawicz TS. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate. Ophthalmology. 1991; (98): 1261. CrossRef  
  9. Early Treatment Diabetes Retinopathy Study Research Group. Fundus photographic risk factors for progression of diabetic retinopathy. Ophthalmology. 1991; (98): 1262.
    10.  
  10. Keating GM, Croom KF. Fenofibrate. A Review of its Use in Primary Dyslipidaemia, the Metabolic Syndrome and Type 2 Diabetes mellitus. Drugs. 2007; (67): 121. CrossRef PubMed
    11.  
  11. Diabetes Atherosclerosis Intervention Study Investigators. Effect of fenofibrate on progression of coronary artery disease in type 2 diabetes; The Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet. 2001; (357): 905. PubMed
    12.  
  12. Wright AD, Dodson PM. Medical management of diabetic retinopathy fenofibrate and ACCORD Eye studies. Eye. 2011; (25): 843. CrossRef PubMed PubMedCentral
    13.  
  13. Keech AC, Mitchell P, Summanen PA, O'Day J, Davis TM, Moffitt MS, Taskinen MR, Simes RJ, Tse D, Williamson E, Merrifield A, Laatikainen LT, d'Emden MC, Crimet DC, O'Connell RL, Colman PG. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet. 2007; (370): 1687. CrossRef

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.