Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(1): 43-52


ASSOSIATION ANALYSYS OF 11 POLYMORPHISMS OF SNPS WITH ENDOTHELIUM DEPENDENT VASODILATATION IN CHILDREN WITH DIABETES MELLITUS TYPE 1

N.B. Pranik1, S.V. Goncharov2, V.L. Gurianova2, V.G. Maidannik1, M.V. Khaitovych1, A.A. Moibenko2, V.E. Dosenko2

  1. Bogomolets National Medical University, Ministry of Health of Ukraine, Kyiv
  2. O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv
DOI: https://doi.org/10.15407/fz62.01.043


Abstract

We have studied the association with the level of the endothelium dependent vasodilatation (EDVD) among 11 single nucleotide polymorphisms (SNPs) of 10 genes in 45 children suffering from diabetes mellitus type 1. Following polymorphisms have been studied: G894→T of the eNOS exon 7 and Т-786→С of the eNOS promotor, А1266→G of the Eln exon 16, Т-381→C of the NPPB promotor, І\D of the ACE, Arg60→His of the LMP2, Met235→Thr of the AGT, A1166→C of the ATR1, C-1562→T of the MMP9, C-1306→T of the MMP2, and С-8→G of the PSMA6. It was shown that children with genotypes G/T by eNOS (G894→T), G/G by Eln (А1266→G), C/C by NPPB (Т-381→C) and І/D by ACE genes have lower EDVD (Р<0,05) than patients with others allelic variants of these genes, and this does not depend on duration of the disease, level of glicated hemoglobin and initial diameter of a humeral (brachial) artery. The combination of the above-stated genotypes influences most significantly on EDVD decrease (r=0,61; Р<0,01), comparing to each genotype separately.

Keywords: single nucleotide polymorphism; endothelium dependent vasodilatation; diabetes mellitus type 1

References

  1. Efimov A, Zueva N, Skrobonskaya N. Diabetic angiopathy: etiology and pathogenesis. Liky Ukrayiny. 2004; 10: 36-8. [Russian].
  2.  
  3. Zargar AH, Wani AI, Masoodi SR, Bashir MI. Mortality in diabetes mellitus - data from a developing region of the world. Diabetes Res Clinical Pract. 1999; 43: 67-74. CrossRef  
  4. Esper R, Nordaby R, Vilarino J, Paragano A, Cacharron J, Machado R. Endothelial dysfunction: a comprehensive appraisal. Cardiovasc Diabetol. 2006; 5: 1470-5. CrossRef PubMed PubMedCentral
  5.  
  6. Schalkwijk CG, Stehouwer CD. Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin Sci. 2005; 109: 143–159. CrossRef PubMed
  7.  
  8. Schiavoni M, Cosentino F, Camici G, Luescher T. Diabetes and Endothelial Dysfunction: What's the Culprit? High Blood Pressure & Cardiovasc. Prevention. 2007; 14 (1): 5-10. CrossRef  
  9. Balabolkin MI, Klebanov EM, Kreminskaya VM. Treatment of diabetes and its complications. Guidelines for doctors. Moscow: Medicine: 2003. [Russian]
  10.  
  11. Ewens K, George R, Sharma K, Ziyadeh F, Spielman R. Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test. Diabetes. 2005; 54: 3305-18. CrossRef PubMed
  12.  
  13. Marre M, Hadjadj S, Bouhanick B. Hereditary factors in the development of diabetic renal disease. Diabetes Metab. 2000; 26 (4): 30–5. PubMed
  14.  
  15. Dedov II, Shestakova MV. Diabetes. Guidelines for doctors. Moscow: The Universe Publishing: 2003.
  16.  
  17. Maidannik VG, Pranik NB. Genetic markers of late complications of 1 type of diabetes mellitus. Pediatriya, Akusherstvo ta Ginekologiya. 2009; 434 (4): 16-27. [Ukrainian].
  18.  
  19. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE., Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 340(8828): 1111-5. CrossRef  
  20. Alvarez R, Gonzalez P, Batalla A, Reguero J, IglesiasCubero G, Hevia S, Cortina A, Merino E, Gonzales I, Alvarez V, Coto E. Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease. Nitric Oxide. 2001; 5 (4): 343-8. CrossRef PubMed
  21.  
  22. Hibi K, Ishigami T, Tamura K, Mizushima S, Nyui N, Fujita T, Ochiai H, Kosuge M, Watanabe Y, Yoshii Y, Kihara M, Kimura K, Ishii M, Umemura S. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension. 1998; 32 (3): 521-6. CrossRef PubMed
  23.  
  24. Vinasco J, Fraile A, Nieto A, Beraun Y, Pareja E, Mataran L, Martin J. Analysis of LMP and TAP polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in rheumatoid arthritis. Ann Rheum Dis. 1998; 57: 33–7. CrossRef PubMed PubMedCentral
  25.  
  26. Tiago AD, Samani NJ, Candy GP, Brooksbank R, Libhaber EN, Sareli P, Woodiwiss AJ, Norton GR. Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension. Circulation. 2002; 17: 1483-7. CrossRef  
  27. Buraczynska M, Ksiazek P, Drop A, Zaluska W, Spasiewicz D, KsiazekA. Genetic polymorphisms of the reninangiotensin systemin end-stage renal disease. Nephrol Dial Transplant. 2006; 21: 979–83. CrossRef PubMed
  28.  
  29. Jones GT, Phillips VL, Harris EL, Rossaak JI, Rij AM. Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm. J Vasc Surg. 2003; 38: 1363-7. CrossRef  
  30. Meirhaeghe A, Sandhu MS, McCarthy MI, de Groote P, Cottel D, Arveiler D, Ferrières J, Groves CJ, Hattersley AT, Hitman GA, Walker M, Wareham NJ, Amouyel P. Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. Hum Mol Genet. 2007 Jun 1;16(11):1343-50. CrossRef PubMed
  31.  
  32. O-charoenrat P, Khantapura P. The role of genetic polymorphisms in the promoter of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes in head and neck cancer. J Oral Oncol. 2006; 42: 257-67. CrossRef PubMed
  33.  
  34. Dosenko VE, Zagoriy VYu, Moibenko AA, Parchomenko AN. Pathophysiological aspects of endothelial NOsyntase genetic polymorphysm. Fiziol Zh. 2002; 48 (6): 86-102. [Ukrainian]. CrossRef PubMed
  35.  
  36. Faury G, Ristori M, Verdetti J, Jacob M, Robert L. Effect of Elastin Peptides on Vascular Tone. J Vasc Res. 1995; 32 (2): 112-9. CrossRef PubMed
  37.  
  38. Hall C. Essential biochemistry and physiology of (NT-pro) BNP. Eur J Heart Fail. 2004; 15(6): 257-60. CrossRef PubMed
  39.  
  40. Sear J, Howard-Alpe G. Preoperative plasma BNP concentrations: do they improve our care of high-risk noncardiac surgical patients? Br J Anaesth 2007; 99 (2): 151-4. CrossRef PubMed
  41.  
  42. Lajer M, Tarnow L, Jorsal A, Parving H. Polymorphisms in the B-type natriuretic peptide (BNP) gene are associated with NT-proBNP levels but not with diabetic nephropathy or mortality in type 1 diabetic patients. Nephrol Dial Transplant. 2007; 22(11): 3235-9. CrossRef PubMed
  43.  
  44. Danser AH, Schalekamp MA, BaxWA, van den Brink AM, Saxena PR, Riegger GA, Schunkert H. Angiotensin-converting enzyme in the human heart. Effect of the deletion/ insertion polymorphism. Circulation. 1995; 92: 1387-88. CrossRef PubMed
  45.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.