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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(5): 52-56


THE ROLE OF NO AND MEXIDOL IN CONTRACTILITY OF OVARIAN AND CERVICAL PARTS OF UTERUS UNDER THE CONDITION OF IMMUNE-MEDIATED INJURY IN MICE

A.P. Lуtvуnenko, T.Yu. Voznesenska, R.I. Yanchiy

    O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv
DOI: https://doi.org/10.15407/fz61.05.052

Abstract

Contractility of ovarian (OP) and cervical parts (СP) of uterus under the condition of immune-mediated injury which was induced by immunization with bovine serum albumin (BSA) was investigated. It was shown that under the activation of energy-synthesizing function of mitochondria with Mexidol the frequency of reductions in both uterine parts decreased, the amplitude and contractility index in the OP and CP as well as the duration of the active state in CP increased. Mexidol under the condition of immunization with BSA leads to the decrease in amplitude in 2,6 time and contractility index in 2,2 time in OP and to the increase of them in CP. It was shown that contractility features of ovarian and cervical parts of uterine under the condition of BSA- induced immunization were caused by changes of mitochondria functional state and were associated with nitric oxide.

Keywords: contractility, ovarian and cervical uterine parts, BSA-immunization, nitric oxide.

References

  1. Mosher AA, Rainey KJ, Bolstad SS. Development and validation of primary human myometrial cell culture models to study pregnancy and labour. BMC Pregnancy and Childbirth. 2013; 13 Suppl 1:S7.
  2.  
  3. Kazaryan KV, Hunanyan NG, Melkonyan NN. Effect of Blood Supply on Parameters of Pacemaker Activity of Rat Uterus. J of Evolutionary Biochem. and Physiol. 2013; 49 (1): 60–6.
  4.  
  5. McCloskey S, Rada S, Bailey E. The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy. EMBO Mol Med. 2014; (6): 1161–74.
  6.  
  7. Volkova NO, Yuhta MS, Yurchuk TO, Stepanuk LV, Ivanova OD. Modeling of chronic ovary infl ammation. Pathologia. 2014; 1 (30): 100–4. [Ukrainian].
  8.  
  9. Prins JR, Kieffer TE, Scherjon SA. Immunomodulators to treat recurrent miscarriage. EurJ Obstet Gynecol Reprod Biol. 2014;181:334-7. CrossRef PubMed
  10.  
  11. Gatto M, Iaccarino L, Canova M, Zen M, Nalotto L, Ramonda R.et al. Pregnancy and vasculitis: a systematic review of the literature. Autoimmun Rev. 2012; 11 (6- 7): 447–59.
  12.  
  13. Danylovych YuV. Nitric oxide as the regulator of intracellular homeostas is in the uterus myocytes. Ukr Biokhim Zh. 2012; 84 (3): 5-25. [Ukrainian].
  14.  
  15. Kalejnikova ON, BlashkivTV, Yanchiy IR, Voznesenskaya TYu. Miometrium contraction activity in conditions of mitochondrion functional changes at mice. Ukr Med Almanac. 2013; 16 (1): 186-8.
  16.  
  17. Shchulkin AV. Effect of mexidol on the development of the phenomenon of the neuronal excitotoxicity in vitro. Zh Nevrol Psikhiatr Im SS Korsakova. 2012;112 (2): 35-9.
  18.  
  19. Yevsegneyeva IV, Dolgushina AI. Administration of Mexidol in treatment of elderly and senile patients with chronic gastrointestinal diseases combined with atherosclerosis in abdominal aorta and age-related macular degeneration. Effective pharmacotherapy.2014, 30 (1): 18-22. [Russian].
  20.  
  21. Lucas R, Fulton D, Caldwell RW, Romero MJ. Arginase in the vascular endothelium: friend or foe? Front Immunol. 2014, Nov 17;5:589.
  22.  
  23. Gullam J, Blanks A, Thornton S, Shmygol A. Phase-plot analysis of the oxytocin effect on human myometrial contractility. Eur J Obstet Gynecol Reprod Biol. 2009; 144 (Suppl. 1): 20-4.
  24.  
  25. Bugrova ML, Kharkovskaya EE, Yakovleva EI. The effect of mexidol on atrial natriuretic peptide in langendorf rat heart preparation. Modern Technologies in Medicine. 2014, 6 (2): 25-31.[Russian].

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.