Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(6): 118-121

ASSESSMENT OF FUNCTIONAL CHANGES TEAR PRODUCTION UNDER THE ACTION OF THE EYE DROPS ON THE BASE OF NATURAL MOLECULE OF EСTOINЕ AND ARTIFICIAL TEARS IN PATIENTS WITH DRY EYE SYNDROME ON THE BACKGROUND OF ENDOCRINE OPHTHALMOPATHY

N.N. Veselovskaya, I.B. Zherebko

    Kyiv Medical University UAFM; Kyiv City Eye Center, KCH №1
DOI: https://doi.org/10.15407/fz62.06.118


Abstract

Conducted a comparative analysis of functional changes in tear production in patients with dry eye syndrome and endocrine ophthalmopathy in the conditions of the long-term acting of preservative free medications based on natural substances. A total of 30 people, aged 35 to 53 years old with clinical manifestations of DES on the background of EO were divided on two groups. In I group eye drops of ectoine and in II – artificial tears were administered. The examination included general and specific methods. The term of follow up - 30 days. It was found that long-term use of preservative free eye drops based on ectoine leads to more expressive positive changes in the condition of the anterior surface of the eye and the secretion and quality of the tear.

Keywords: endocrine ophthalmopathy; dry eye syndrome; irritation; natural molecule of ectoine.

Full text: (PDF, in Ukrainian)

References

  1. Veselovskay ZF, Veselovskay NN. New approaches to pharmacotherapy of allergic eye diseases. INTSCI and PRACT J «Ophthalmology». 2015; (1): 18. [Russian].
    2.  
  2. Zabegaylo AO, Polunin GS, Polunina YeG, Kasparova YeA. Modern ideas about blepharoconjunctival form of dry eye syndrome. J Ophthalmol. 2007; (2): 45 .[Russian].
    3.  
  3. Gallinski EA, Pfeiffer HP, Truper HG. 1,4,5,6-Tetrahydro- 2-methyl-4-pyrimidinecarboxylic acid-a novel cyclic amino-acid from halophilic phototrophic bacteria of genus Ectothiohodospira. Eur J Biochem. 1985; (149): 135.
    4.  
  4. Marube J, Nemeth J, Hoh K. The triple classification of dry eye for practical and clinical use. Eur J Ophthalmol. 2005; (15): 660.
    5.  
  5. Shine WE, McCulley JP. Keratoconjunctivitis sicca associated with meibomian secretion polar lipid abnormality. Arch Ophthalmol. 1998; (116): 849.
    6.  
  6. Dews Membership. Report of the International Dry Eye Workshop (DEWS). Ocul Surf. 2007; (5): 65.
    7.  
  7. Wollensak G, Mur E, Mayr F, Baier G. Effective methods for the investigation of human tear lipids. Chem and Phys Lipid. 2007; (147): 87.
    8.  
  8. Brzheskiy VV, Somov YeYe. Kerato-conjunctival xerosis (clinic, diagnostics, treatment), 2003.- 120 p. [Russian].
    9.  
  9. Brovkina AF, Panteleeva OG. Prevention and treatment of the syndrome of "dry eye" with endocrine ophthalmopathy Dry eye syndrome. Special edit Moscow Associat Ophthalmol. 2003. -№4. - P. 21. [Russian].
    10.  
  10. Drozhzhina GI, Troychenko LF. New possibilities of substitution of the lipid layer of the tear film. J Ophthalmol. 2015; (3): 13 p. [Russian].
    11.  
  11. Rantamäki AH, Seppänen-Laakso T, Oresic M. Human tear fluid lipidome: from composition to function. PloS One. 2011; (6). doi: 10.1371/journal.pone.0019553. CrossRef  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.