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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(6): 88-94


R.V. Yanko

    O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv


Morphological changes of the pancreas of young rats after exposure of exogenous melatonin in the spring and autumn periods was investigated. Exogenous melatonin (Unipharm Inc., USA) was administered to experimental group of animals daily at a dose 5 mg/kg. The duration of the experiment was 28 days. It was revealed that the exocrine part of the pancreas responds differently to the effects of melatonin at different times of the year. Thus, after administration of melatonin in the spring increase of the size of acinus, the height of the epithelium (by 7 %), area exocrinocytes (by 58 %), of their nucleus (by 20 %) and cytoplasm (69 %), the amount of nucleoli in cells (18 %), reduction the amount of connective tissue elements. Melatonin introduction in the autumn decrease in the size of acinus, height and area of exocrinocytes, growth the number of exocrinocytes in the acinus, nucleoli and width layers interlobular connective tissue in the gland. This may indicate that melatonin increases in the spring of the synthetic activity of the exocrine pancreas, whereas in the autumn (for the majority of the morphometric parameters) – somewhat reduces its functional state. The administration of melatonin in the spring (mostly) and in the autumn periods increased the functional activity of the endocrine pancreas. This is indicated by growth in the size of Langerhans islets, increasing the number and density of the (autumn) endocrinocytes.

Keywords: melatonin; pancreas


  1. Fedyukovich N. Anatomy and physiology human: Textbook. Rostov: Phoenix. 2002. [Russian].
  3. Anisimov V. Melatonin: role in an organism, application in a clinic. SPB: Sistema. 2007. [Ukrainian].
  5. Yıldırım A, Tuncer M, Pamukcu O, Aktas A, Akkus M. Effects of іschemia / reperfusion on β cells of pancreas and protective effects of melatonin treatment. Int J Morphol. 2009; 27 (2): 519–25. CrossRef  
  6. Cuesta S, Kireev R, García C, Rancan L, Vara E, Tresguerres J. Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8). Age (Dordr). 2013; 35 (3): 659–71. CrossRef PubMed PubMedCentral
  8. Svechkina E, Tyutyunnik N, Vinogradova I. Influence of light regimes, melatonin and epithalon on the activity of pancreatic and intestinal amylase in rats of different ages. Advances Gerontol. 2006; 19: 66–71. [Russian].
  10. Ramraeheya R, Muller D, Squires P. Function and expression of melatonin receptors on human pancreatic islets. J Pineal Res. 2008; 44 (3): 273–79. CrossRef PubMed
  12. Peschke E, Bach A, Villbaurer E. Parallel signaling pathways of melatonin in the pancreatic beta-cell. J Pineal Res. 2006; 40 (2): 184–91. CrossRef PubMed
  14. Yanko R. Morphological characteristics of the exocrine pancreas after administration of exogenous melatonin. Materials of XV scientific conference of students and young scientists «News and perspectives of medical science». 2015; 48–9. [Ukrainian].
  16. Kushnir Yu, Davydenko I. Influence of melatonin on condition pancreatic islets in aloksa-diabetic rats. World of Med and Biolog. 2009; 4: 31–5. [Ukrainian].
  18. Korzhevsky D. Principles of histological techniques. SPb: SpetsLit. 2010. [Russian].
  20. Verigo L. Variability of connective tissue of the pancreas. (Morpho-experimental research). Author. dissertations. 03.00.13. Physiology: Moscow. 2005. [Russian].
  22. Nikolaeva O, Kovaltsova M, Gorgol N. Morphofunctional characteristics of pancreas of rats with chronic stress. Theoretic and Experien Med. 2013; 59 (2): 23–7. [Russian].
  24. Lima L, Reis L, Lima M.Influence of the pineal gland on the physiology, morphometry and morphology of pancreatic islets in rats. Rev Brasil Biol. 2001; 61 (2): 333–40. CrossRef  
  25. Goncharova N, Khavinson V, Lapin B. Pineal gland: age pathology (mechanisms and correction). St.Petersburg: Nauka. 2007. [Russian].
  27. Mehmet K, Hamdi U, Turan K, Ozdemir S. Depression of glucose levels and partial restoration of pancreatic b-cell damage by melatonin in streptozotocin-induced diabetic rats. Arch Toxicol. 2006; 80 (6): 362–9. CrossRef PubMed
  29. El-Desouk N, Basyony M, El-Nenaey M, Abdel-Magied R. Histological and cytological studies on the effect of melatonin on experimentally induced pancreatic diabetes in rats. Egypt J Exp Biol (Zool). 2007; 3: 69–82.

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