|
|
|
|
|
|
MORPHOLOGICAL CHANGES PANCREAS AFTER OF MELATONIN’S EFFECT IN DIFFERENT SEASONS
R.V. Yanko
O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv
DOI: https://doi.org/10.15407/fz62.06.088
![](/images/cite.png)
Abstract
Morphological changes of the pancreas of young rats after
exposure of exogenous melatonin in the spring and autumn
periods was investigated. Exogenous melatonin (Unipharm
Inc., USA) was administered to experimental group of
animals daily at a dose 5 mg/kg. The duration of the experiment
was 28 days. It was revealed that the exocrine part of
the pancreas responds differently to the effects of melatonin
at different times of the year. Thus, after administration of
melatonin in the spring increase of the size of acinus, the
height of the epithelium (by 7 %), area exocrinocytes (by
58 %), of their nucleus (by 20 %) and cytoplasm (69 %), the
amount of nucleoli in cells (18 %), reduction the amount of
connective tissue elements. Melatonin introduction in the
autumn decrease in the size of acinus, height and area of
exocrinocytes, growth the number of exocrinocytes in the
acinus, nucleoli and width layers interlobular connective tissue
in the gland. This may indicate that melatonin increases in
the spring of the synthetic activity of the exocrine pancreas,
whereas in the autumn (for the majority of the morphometric
parameters) – somewhat reduces its functional state. The
administration of melatonin in the spring (mostly) and in
the autumn periods increased the functional activity of the
endocrine pancreas. This is indicated by growth in the size
of Langerhans islets, increasing the number and density of
the (autumn) endocrinocytes.
Keywords:
melatonin; pancreas
References
- Fedyukovich N. Anatomy and physiology human: Textbook. Rostov: Phoenix. 2002. [Russian].
- Anisimov V. Melatonin: role in an organism, application in a clinic. SPB: Sistema. 2007. [Ukrainian].
- Yıldırım A, Tuncer M, Pamukcu O, Aktas A, Akkus M. Effects of іschemia / reperfusion on β cells of pancreas and protective effects of melatonin treatment. Int J Morphol. 2009; 27 (2): 519–25.
CrossRef
- Cuesta S, Kireev R, García C, Rancan L, Vara E, Tresguerres J. Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8). Age (Dordr). 2013; 35 (3): 659–71.
CrossRef
PubMed PubMedCentral
- Svechkina E, Tyutyunnik N, Vinogradova I. Influence of light regimes, melatonin and epithalon on the activity of pancreatic and intestinal amylase in rats of different ages. Advances Gerontol. 2006; 19: 66–71. [Russian].
- Ramraeheya R, Muller D, Squires P. Function and expression of melatonin receptors on human pancreatic islets. J Pineal Res. 2008; 44 (3): 273–79.
CrossRef
PubMed
- Peschke E, Bach A, Villbaurer E. Parallel signaling pathways of melatonin in the pancreatic beta-cell. J Pineal Res. 2006; 40 (2): 184–91.
CrossRef
PubMed
- Yanko R. Morphological characteristics of the exocrine pancreas after administration of exogenous melatonin. Materials of XV scientific conference of students and young scientists «News and perspectives of medical science». 2015; 48–9. [Ukrainian].
- Kushnir Yu, Davydenko I. Influence of melatonin on condition pancreatic islets in aloksa-diabetic rats. World of Med and Biolog. 2009; 4: 31–5. [Ukrainian].
- Korzhevsky D. Principles of histological techniques. SPb: SpetsLit. 2010. [Russian].
- Verigo L. Variability of connective tissue of the pancreas. (Morpho-experimental research). Author. dissertations. 03.00.13. Physiology: Moscow. 2005. [Russian].
- Nikolaeva O, Kovaltsova M, Gorgol N. Morphofunctional characteristics of pancreas of rats with chronic stress. Theoretic and Experien Med. 2013; 59 (2): 23–7. [Russian].
- Lima L, Reis L, Lima M.Influence of the pineal gland on the physiology, morphometry and morphology of pancreatic islets in rats. Rev Brasil Biol. 2001; 61 (2): 333–40.
CrossRef
- Goncharova N, Khavinson V, Lapin B. Pineal gland: age pathology (mechanisms and correction). St.Petersburg: Nauka. 2007. [Russian].
- Mehmet K, Hamdi U, Turan K, Ozdemir S. Depression of glucose levels and partial restoration of pancreatic b-cell damage by melatonin in streptozotocin-induced diabetic rats. Arch Toxicol. 2006; 80 (6): 362–9.
CrossRef
PubMed
- El-Desouk N, Basyony M, El-Nenaey M, Abdel-Magied R. Histological and cytological studies on the effect of melatonin on experimentally induced pancreatic diabetes in rats. Egypt J Exp Biol (Zool). 2007; 3: 69–82.
|
|
|
|
|
|
|
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
|
|