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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(2): 65-72


THE INFLUENCE OF MELANIN ON THE GASTRIC MUCOSA AND HYPOTHALAMICPITUITARY-ADRENOCORTICAL AXIS UNDER ACUTE STRESS CONDITIONS

Golyshkin D.V.1, Falalyeyeva T.M.1, Neporada K.S.2, Beregova T.V.1

  1. “Institute of Biology” of Taras Shevchenko National University, Kyiv
  2. Higher medical educational institution of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava
DOI: https://doi.org/10.15407/fz61.02.065

Abstract

We studied the influence of melanin from yeast-like fungi Nadsoniella nigra strain X1 on the changes of the levels of adrenocorticotropic hormone (ACTH) and сortisol in blood serum of rats, adrenal glands weight ratio and lesions of the gastric mucosa (GM) caused by neuromuscular tension by Selye. Melanin administration restored functioning of the hypothalamic-pituitary-adrenal axis that was evident by an increase of ACTH concentration by 42% and a decrease of сortisol concentration by 19% compared to the rats injected with water (group 2). In rats treated with melanin, the adrenal glands weight ratio, didn’t differ from intact control group of the rats. Melanin decreased ulcers area by 64% and reduced the content of free hydroxyproline by 29 %, the free fucose by 16% and the free hexuronic acids by 24% in the GM compared to the group 2 of the rats. It is established that the mechanism of melanin stress-protective properties are based on its regulation of the glucocorticoids secretion and prevention of GM collagen and extracellular matrix substances depolymerization. Melanin possesses gastroprotective properties and is a perspective agent for preventing and treatment of consequences of the stress influence on the organism.

Keywords: melanin; сortisol; adrenocorticotropic hormone; gastric mucosa; stress.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.