INFLUENCE OF COMPLEX NATURAL SUBSTANCES TRIGONELA FOENUM GRAECUM L. SEEDS ON FORMING ABERRANT CRYPT FOCI IN THE MUCOSA AT EXPERIMENTAL COLON CANCER IN RATS
O.A. Kravchenko, I.V. Yakubtsova, T.D. Khilko, T.D. Preobrazhenska, L.I. Ostapchenko, V.F. Chekhun
T. Shevchenko Kyiv National University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.06.062
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Abstract
Aberrant crypt Foci are considered preneoplastic colonic
lesions and biomarkers for screening potential chemoprotective
substances. Colorectal cancer therapy leads to toxic side
effects. Natural biologically active substances are increasingly
being used to counteract neoplastic processes. The influence
of Trigonella foenum graecum L. on the state of the colonic
mucosa on the model of experimental colon carcinogenesis
in rats in the dynamics of pathological changes. It is shown
a possible hepatoprotective effect and reduction of single
aberrant crypts Foci 40%, multicrypts Foci – 31% in the
colonic mucosa of animals treated finely dispersed powder
together with the standard feed.
Keywords:
aberrant crypts Foci, colon mucosa, Trigonellafoenum graecum
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