Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(6): 62-68

INFLUENCE OF COMPLEX NATURAL SUBSTANCES TRIGONELA FOENUM GRAECUM L. SEEDS ON FORMING ABERRANT CRYPT FOCI IN THE MUCOSA AT EXPERIMENTAL COLON CANCER IN RATS

O.A. Kravchenko, I.V. Yakubtsova, T.D. Khilko, T.D. Preobrazhenska, L.I. Ostapchenko, V.F. Chekhun

    T. Shevchenko Kyiv National University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.06.062


Abstract

Aberrant crypt Foci are considered preneoplastic colonic lesions and biomarkers for screening potential chemoprotective substances. Colorectal cancer therapy leads to toxic side effects. Natural biologically active substances are increasingly being used to counteract neoplastic processes. The influence of Trigonella foenum graecum L. on the state of the colonic mucosa on the model of experimental colon carcinogenesis in rats in the dynamics of pathological changes. It is shown a possible hepatoprotective effect and reduction of single aberrant crypts Foci 40%, multicrypts Foci – 31% in the colonic mucosa of animals treated finely dispersed powder together with the standard feed.

Keywords: aberrant crypts Foci, colon mucosa, Trigonellafoenum graecum

Full text: (PDF, in Ukrainian)

References

  1. Nikishaev VI, Patiy AR, Tumak IN, Kolyada IA Endoscopic diagnostics of early colorectal cancer. Ukr J Min Invasive and Endoscopic Surgery. 2012; 16: 35-55.
    2.  
  2. Alrawi SJ, Schiff M, Carols RE, et al., Aberrant Crypt Foci. Anticancer Res. 2006; 26: 107-120. PubMed
    3.  
  3. Jian-Guo Wang, Dong-Fei Wang, Bing-Jian Lv, Jian-Min Si. A novel mouse model for colitis-associated colon carcinogenesis induced by 1, 2-dimethylhydrazine and dextran sulfate sodium. World J Gastroenterol. 2004; 10(20). – P. 2958–2962.
    4.  
  4. Plechyschik ED, Goncharova LV, Spiridovich EV, Reshetnikov VN. Fenugreek (Trigonella foenum graecum L.) as a source of a wide variety of biologically active compounds. Proceedings of the Belarusian State University. Ser. "Physiological, Biochemical and Molecular Biology Sciences." 2009; 4 (2): 138-146.
    5.  
  5. Murakami T, Kishi A, Matsuda H, Yoshikawa M. Medicinal foodstuffs. XVII. Fenugreek seed (3): structures of new furostanoltype steroid saponins, trigoneosides Xa, Xb, XIb, XIIa, XIIb, and XIIIa, from the seeds of Egyptian Trigonella foenum graecum L. Chem Pharm Bull (Tokyo) 2000;48:994-1000. CrossRef  
  6. Mehrafarin A, Qaderi A, Rezazadeh N., et al. Bioengineering of important secondary metabolites and metabolic pathways in fenugreek (Trigonella foenum-graecum L.). J Med Plants. 2010; 9 (35): 1–18.
    7.  
  7. Sur P, Das M, Gomes A, et al. Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent. Phytother Res. 2001;15:257-9. CrossRef PubMed
    8.  
  8. Hibasami H, Moteki H, Ishikawa K, et al. Protodioscin isolated from fenugreek (Trigonella foenum graecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III. Int J Mol Med. 2003; 11: 23-6. PubMed
    9.  
  9. Norton SA. Useful plants of dermatology. III. Corticosteroids, strophanthus, and dioscorea. J Am Acad Dermatol. 1998; 38:256-9. CrossRef  
  10. Moalic S, Liagre B, Corbiere C, et al. A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. FEBS Lett. 2001; 506:225- 30. CrossRef  
  11. Chen Y, Jungsuwadee P, Vore M., et al. Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues. Mol. Interv. 2007; 7 (3): 147–156. CrossRef PubMed
    12.  
  12. Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Altem. Ther. Health Med. 2007; 13: 22–28. PubMed
    13.  
  13. Prasad KN. Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity. Integr. Cancer Ther. 2004; 3:310–322. CrossRef PubMed
    14.  
  14. Devasena T. Fenugreek affects the activity of ?-glucuronidase and mucinase in the colon. Phytother Res. 2003; 17: 1088-1091. CrossRef PubMed
    15.  
  15. Shaban A, Jahanmehr SA, Rezaeeian M, et al. Fenugreek (Trigonella Foenum Graecum L.) Seed Extract Induces Cell Death, Growth Inhibition and Morphological Change Indicative of Apoptosis in Acute Lymphoblastic Leukemia. Res J Biol Sci. 2007; 2 (4): 438-43.
    16.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.