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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(6): 62-68


INFLUENCE OF COMPLEX NATURAL SUBSTANCES TRIGONELA FOENUM GRAECUM L. SEEDS ON FORMING ABERRANT CRYPT FOCI IN THE MUCOSA AT EXPERIMENTAL COLON CANCER IN RATS

O.A. Kravchenko, I.V. Yakubtsova, T.D. Khilko, T.D. Preobrazhenska, L.I. Ostapchenko, V.F. Chekhun

    T. Shevchenko Kyiv National University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.06.062

Abstract

Aberrant crypt Foci are considered preneoplastic colonic lesions and biomarkers for screening potential chemoprotective substances. Colorectal cancer therapy leads to toxic side effects. Natural biologically active substances are increasingly being used to counteract neoplastic processes. The influence of Trigonella foenum graecum L. on the state of the colonic mucosa on the model of experimental colon carcinogenesis in rats in the dynamics of pathological changes. It is shown a possible hepatoprotective effect and reduction of single aberrant crypts Foci 40%, multicrypts Foci – 31% in the colonic mucosa of animals treated finely dispersed powder together with the standard feed.

Keywords: aberrant crypts Foci, colon mucosa, Trigonellafoenum graecum

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