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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(6): 16-21


THE ASSOCIATION OF PROMOTER GENE MATRIX METALLOPROTEINASE-9 POLYMORPHISM C-1562→T WITH THE RISK OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN MINERS

A.V. Basanets, L.V. Dolinchuk, T.A. Andrushchenko

    SI “Institute of Occupational Health of NAMS of Ukraine”,Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.06.016

Abstract

We analyzed genetic markers of genetic susceptibility that lead to development of chronic obstructive pulmonary disease (COPD) of occupational etiology. Polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis were performed to detect a point mutation at the promoter of C-1562ЃЁT (rs3918242) of the matrix metalloproteinase- 9 (MMP-9) gene. The study comprised 72 miners with COPD, and 79 miners without respiratory system pathology. The frequency of allocation for genotypes MMP-9 gene polymorphism C-1562ЃЁT was similar to Caucasian population. The study established the association between the minor T-allele (Odds Ratio (OR) = 1.89; 95% confidence interval (CI): 0.98-3.66) and TT (OR = 2.18; 95% CI: 1.83-2.60) and CT (OR = 1.21; 95% CI: 0.56-2.66) genotypes with the risk of COPD in miners of main underground occupations. Presence in the genome dominant C-allele (OR = 0.53; 95% CI: 1.02-0.27) and CC genotype (OR = 0.60; 95% CI: 0.28 - 1.28) determine the relative protective role in risk to COPD among respondents of the studied group. The results of research opens new perspectives for improving measures of primary prevention of COPD based on determining genetic predisposition to COPD development.

Keywords: chronic obstructive pulmonary disease, geneticpredisposition, miners of major underground occupations.

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