Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(6): 49-56


The effect of water with modified isotope content on the parameters of free radical oxidation in vivo

Basov AA1, Baryshev MG1, Dzhimak SS2, Bykov IM2, Sepiashvili RI3, Pavliuchenko II3

  1. Kuban National University, Krasnodar, Russia
  2. South Scientific Center RAS, the laboratory of “Problems of natural and new matherials” Rostov-on-Don, Russia
  3. Institute of Immunophysiology, Moscow, Russia
DOI: https://doi.org/10.15407/fz59.06.049


Abstract

With the use of nuclear magnetic resonance we investigated the effect of consumption of water with the modified isotope content on the composition of deuterium in the blood, assessed the state of pro-oxidant-antioxidant system in the blood and lyophilized tissues (liver, kidneys) under prolonged oxidative stress. Possible mechanisms of direct and indirect antioxidant effects of the water with modified isotope content and the perspectives of its use for nutritional correction of abnormalities of oxidative metabolism during special physiological conditions and in clinical practice are discussed.

Keywords: consumption of water, free radical, oxidation

References

  1. Azhipa Ya.I. Medikobiologicheskie aspekti primeneniya metoda elektronnogo paramagnitnogo rezonansa. M.: Nauka, 1983. 528 p.
  2.  
  3. Basov A.A., Bikov I.M., Fedosov S.R., Malishko V.V.«Sposob hirurgicheskogo modelirovaniya okislitel'nogo stressa u laboratornih zhivotnih». Polozhitel'noe reshenie o vidache patenta na izobretenie pozayavke N 2011100352. 14 (000483) ot 11.01.2011.
  4.  
  5. Basov A.A., Pavlyuchenko I.I., Plaksin A.M., FedosovS.R. Ispol'zovanie analogovotsifrovogo preobrazovatelya v sostave sistemi sbora i obrabotki informatsii s hemilyuminitesterom LT1 .Vestn. novih med.tehnologii. 2003. 10, N 4. P. 67-68.
  6.  
  7. Bahvalov N.S., Zhidkov N.P., Kobel'kov G.M. Chislenniemetodi. M.: Fizmatlit, 2001. 630 p.
  8.  
  9. Borovik E.S, Eremenko V.V., Mil'ner A.S. Lektsii pomagnetizmu. M.: Fizmatlit, 2005. 512 p.
  10.  
  11. Vladimirov Yu.A., Proskurina E.V., Izmailov D.Yu,Kineticheskaya hemilyuminestsentsiya kak metod izucheniya reaktsii svobodnih radikalov .Biofizika. 2011. 56, vip. 6. P.1081-1090.
  12.  
  13. Kolesova O.E., Pomitkin I.A. Vliyanie estestvennoikontsentratsii tyazhelih izotopologov vodi na skorost'generatsii N2O2 mitohondriyami . Byul. eksperim.biologii i meditsini. 2006. N 11. P.514-516.
  14.  
  15. Lobishev V.N., Kalinichenko L.P. Izotopnie effektiD2O v biologicheskih sistemah. M.: Nauka, 1978. 215 p.
  16.  
  17. Mirhaidarov A.R. Issledovanie hemilyuminestsentsiikrovi i mochi u bol'nih v kriticheskih sostoyaniyah .Materiali nats. nauchn.prakt. konf. s mezhdunarod.uchastiem «Svobodnie radikali, antioksidanti ibolezni cheloveka». Smolensk, 2001. P.212-214.
  18.  
  19. Pavlyuchenko I.I., Basov A.A., Fedosov S.R. Sistemalaboratornoi diagnostiki okislitel'nogo stressa.Pat. na poleznuyu model' N 54787. Zayavl. 19.01.2006;opubl. 27.07.2006. B.21.
  20.  
  21. Pavlyuchenko I.I., Fedosov S.R., Basov A.A. Programmaregistratsii signalov hemilyuminotestera LT1. Svidetel'stvo ob ofitsial'noi registratsii programmidlya EVM N 2006611562. Zayavl. N 2006610783 ot16.03.2006.
  22.  
  23. Pat. 2438765 Rossiiskaya Federatsiya, MPK B01D 59. 40(2006.01). Sposob polucheniya biologicheski aktivnoipit'evoi vodi s ponizhennim soderzhaniem deiteriya[Tekst] . Frolov V.Yu., Barishev M.G., Bolotin S.N.,Dzhimak S.S.; zayaviteli i patentoobladateli gosudarstvennoe obrazovatel'noe uchrezhdenie visshegoprofessional'nogo obrazovaniya «Kubanskii gosudarstvennii universitet» (RU) N 2010121324. 05;zayavl. 25.05.2010; opubl. 10.01.2012, Byul. N 1. 7 p.
  24.  
  25. Pat. 2438766 Rossiiskaya Federatsiya, MPK B01D 59. 40(2006.01). Sposob polucheniya biologicheski aktivnoipit'evoi vodi s ponizhennim soderzhaniem deiteriya[Tekst] . Frolov V.Yu., Barishev M.G., Lomakina L.V.,A.A. Basov, M.G. Barishev, S.S. Dzhimak, I.M. Bikov, R.I. Sepiashvili, I.I. Pavlyuchenko, Dzhimak S.S.; zayaviteli i patentoobladateli Uchrezhdenie Rossiiskoi akademii nauk Yuzhnii nauchniitsentr RAN (RU), gosudarstvennoe obrazovatel'noeuchrezhdenie visshego professional'nogo obrazovaniya«Kubanskii gosudarstvennii universitet» (RU) 2010121326. 05; zayavl. 25.05.2010; opubl. 10.01.2012,Byul. N 1. 7 p.
  26.  
  27. Pulatova M.K. Rihireva G.T., Kuropteva Z.V. Elektronnii paramagnitnii rezonans v molekulyarnoiradiobiologii. M.: Energoatomizdat, 1989. 232 p.
  28.  
  29. Rakov D.V. Vliyanie vodi s ponizhennim soderzhaniemdeiteriya i kisloroda 18O na razvitie luchevih povrezhdenii posle gammaoblucheniya .Aviakosm. i ekol.meditsina. 2007. 41, N 3. P.36-39.
  30.  
  31. Rakov D.V., Erofeeva L.M., Grigorenko D.E. Vliyanievodi s ponizhennim soderzhaniem tyazhelogo stabil'nogo izotopa vodoroda deiteriya i kisloroda 18O narazvitie luchevih povrezhdenii pri gamma obluchenii v nizkoi doze. Radiats. biologiya. Radioekologiya.2006. 46, N 4. P.475-479.
  32.  
  33. Yashin A.Ya. Inzhektsionnoprotochnaya sistema s amperometricheskim detektorom dlya selektivnogo opredeleniya antioksidantov v pishchevih produktah i napitkah. Ros. him. zhurn. 2008. T. LII, N 2. P.130-135.
  34.  
  35. Bild W., Nastasa V., Haulica I. In vivo and in vitro researchon the biological effects of deuteriumdepleted water:Influence of deuteriumdepleted water on cultured cellgrowth .Rom. J. Physiol. 2004. N 41(12). P.53-67.
  36.  
  37. Bild W., Stefanescu I., Haulica I. Research concerningthe radioprotective and immunostimulating effects ofdeuteriumdepleted water . Rom. J. Physiol. 1999. N 36 (34). P.205-218.
  38.  
  39. Fengsong Cong, Yaru Zhang, Hongcai Sheng, ZonghuaAo,Suyi Zhang, Juyong Wang Deuteriumdepletedwater inhibits human lung carcinoma cell growth byapoptosis .Exp. and Therap. med. 2010. N 1. P.277-283.
  40.  
  41. Olariu L., Petcu M., Tulcan C., ChisBuiga I., Pup M.,Florin M., Brudiu I. Deuterium depleted water antioxidantor prooxidant? .Luc. Stiinlif. Med. Veterin. 2007. Timisoara. Vol. XL. P.265-269.
  42.  
  43. Olariu L., Petcu M., Cuna S. The role of deuterium depletedwater (ddw) administration in blood deuterium concentrationin Cr (VI) intoxicated rats . Luc. Stiinlif. Med.Veterin. (2), 2010. Timisoara. Vol. XLIII. P.193-196.
  44.  
  45. Somlyai G. Naturally occurring deuterium is essential forthe normal growth rate of cells .FEBS Let. 1993. 317,N 1,2. P.14.
  46.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.