Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(4): 63-66


Pathogenesis of skin injury in immunodeficient rats

Shukhtin VV2, Hozhenko AI1, Levyts'kyĭ AP2

  1. Institute of medicine of transport, Odesa, Ukraine
  2. Dental Institute, Odesa, Ukraine
DOI: https://doi.org/10.15407/fz59.04.063

Abstract

We investigated the skin condition in rats with immunodeficit induced by cyclophosphane. Cyclophosphane induced in the blood the development of two phases pathological process. The first leukopenic phase is mediated by the action ofcytostatics, and the second hyperleucocytic phase is induced by liver injury and splenomegalia. Dysbiosis and inflammation are developed in the skin, especially during the second phase.

Keywords: pathogenesis, skin, injury, rats, immunodeficit

References

  1. Aleshina R.M. Sindrom vtorichnoi immunnoi nedo statochnosti: kliniko-laboratornaya harakteristika . Klin. imunologiya, alergologiya, infektologiya. 2007. N 2 (107). P. 17-20.
  2.  
  3. Asatiani V.S. Novie metodi biohimicheskoi fotometrii. M.: Nauka, 1965. 298 p. PubMed
  4.  
  5. Baranovskii A.Yu., Kondrashina E.A. Disbakterioz kishechnika. M.: Piter, 2007. 240 p. PubMed
  6.  
  7. Volyanskii Yu.L., Telepneva L.G., Vasil'ev N.V. VICh-infektsiya (fakti i gipotezi). Har'kov: Osnova, 1993. 224 p.
  8.  
  9. Grigor'yan A.S., Volozhin A.I., Shumtikova E.V. Eksperimental'noe obosnovanie primeneniya radioprotektora indometatsina dlya kupirovaniya vospaleniya v Patogenez urazhen' shkiri parodonte pri immunodefitsitnom sostoyanii . Patol. fiziologiya. 1998. N 3. P. 15-18.
  10.  
  11. Goryachkovskii A.M. Klinicheskaya biohimiya v laboratornoi diagnostike. Izd. 3-e. Odessa: Ekologiya, 2005. 616 p.
  12.  
  13. Zaporozhan V.M., Aryaiev M.L. VIL-infektsiya i SNID. K.: Zdorov'ya, 2004. Vid. 2-ge. 636 p.
  14.  
  15. Levitskii A.P., Den'ga O.V., Makarenko O.A. Biohimicheskie markeri vospaleniya tkanei rotovoi polosti: metod. Rekomendatsii. Odessa, 2010. 16 p.
  16.  
  17. Onishchenko G.G. Epidemiologicheskoe blagopoluchie Rossii . ZhMEI. 2013. N 1. P. 42-51. 
  18.  
  19. Patent na korisnu model' 43140 Ukraina, MPK (2009) G01N 33/48. Sposib otsinki stupenya disbiozu (disbakteriozu) organiv i tkanin. Levits'kii A.P., Den'ga O.V., Selivans'ka I.O. N u200815092. Zayavl. 26.12.08; opubl. 10.08.09, Byul. N 15. 
  20.  
  21. Polesko I.V., Butov Yu.S., Malinovskaya V.V. Rol' endotoksinemii v formirovanii deskvamativnih porazhenii kozhi . Ros. zhurn. kozhnih i vener. boleznei. 2009. N 3. P. 38-41.
  22.  
  23. Yakovlev M.Yu. «Endotoksinovaya agressiya» kak predbolezn' ili universal'nii faktor patogeneza zabolevanii cheloveka i zhivotnih . Uspehi sovrem. biohimii. 2003. 123, N 1. P. 31-40.
  24.  
  25. Drake D.R., Brogden K.A., Dawson D.V. Antimicrobial lipids at the skin surface . J. Lipid Res. 2008. 49, N 1. P. 4-11. CrossRef PubMed
  26.  
  27. Khoshini R.A., Dai Sun-Chuan, Lezcano S. A systematic review of diagnostic tests for small intestinal bacterial overgrowth . Dig. Diseases and Sci. 2008. 33, N 6. P. 1443-1454. CrossRef PubMed
  28.  
  29. Moro J., Arslanoglu S., Stahl B. A mixture of prebiotic oligosaccharide reduces the incidence of atopic dermatitis during the first six months of age . Arch. Dis. Child. 2006. 91, N 10. P. 814-819. CrossRef PubMed PubMedCentral
  30.  
  31. Wang X., Quinn P. Endotoxins: Structure, Function and Recognition . Seria: Subcellulare Biochemistry. 2010. 53. 415 p.
  32.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.