Pathogenesis of skin injury in immunodeficient rats
Shukhtin VV2, Hozhenko AI1, Levyts'kyĭ AP2
- Institute of medicine of transport, Odesa, Ukraine
- Dental Institute, Odesa, Ukraine
DOI: https://doi.org/10.15407/fz59.04.063
Abstract
We investigated the skin condition in rats with immunodeficit induced by cyclophosphane. Cyclophosphane induced in the blood the development of two phases pathological process. The first leukopenic phase is mediated by the action ofcytostatics, and the second hyperleucocytic phase is induced by liver injury and splenomegalia. Dysbiosis and inflammation are developed in the skin, especially during the second phase.
Keywords:
pathogenesis, skin, injury, rats, immunodeficit
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