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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(1): 84-88

The interferon production by rat spleen and thymus lymphocytes in condititons of hypoacidity

Kompanets' IV, Korotkyĭ OH, Nikols'ka VV, Ostapchenko LI, Pylypenko SV

    SSC Institute of Biology Taras Shevchenko NationalMedical University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.01.084


Abstract

The interferon production by rat spleen and thymus lymphocytes in conditions of gastric juice hypoacidity, evoked by 28 days of omeprazole treatment, was studied. It was shown that the spontaneous and induced by PHA and cycloferone interferon titer increases in thymocyte and sleenocyte cell cultures under the action of omeprazole. This effect was more expressed in thymocytes. It might be a result of stimulation of interferon secretion by lymphoid cells. Probably the interferon synthesis intensifies in conditions of hypoacidity. This effect may be considered as the reaction of immune system on inflammation in gastro-intestinal tract.

Keywords: interferon, lymphocytes, spleen, thymus, omeprazole, hypoacidity

Full text: (PDF, in Ukrainian)

References

  1. Voronina O.K., Grishchuk V.M. Dinamika zmin v slizovii obolontsi shlunka shchuriv pri gipergastrinemii riznoi trivalosti . Tezi dop. III Vseukr. nauk. konf. «Psihofiziologichni ta vistseral'ni funktsii v normi i patologii». K., 4-6 zhovtnya 2006 r. p. 24.
    2.  
  2. Korotkii O.G., Pilipenko S.V., Kompanets' I.V., Ostapchenko L.I. Reaktsiya limfoidnih organiv shchuriv na vvedennya mul'tiprobiotika «SimbiterT atsidofil'nii» kontsentrovanii za umov trivalogo znizhennya shlunkovoi sekretsii solyanoi kisloti . Visn. problem biologii i meditsini. 2010. Vip. 3. p. 55-60.
    3.  
  3. Korotkii O., Pilipenko S., Tsiryuk O., Ostapchenko L., Beregova T. Vpliv mul'tiprobiotikiv na vmist interferonu-gamma v sirovattsi krovi shchuriv za umov trivaloi gipoatsidnosti . Visn. Kiiv. nats. un-tu. Biologiya. 2009. vip. 54. p.47-49.
    4.  
  4. Morozov V.G., Havinson V.H. Immunologicheskaya funktsiya timusa . Uspehi sovr. biologii. 1985. 97, N 1. S. 36-49.
    5.  
  5. Tsiryuk O.I., Beregova T.V. Vpliv omeprazol-viklikanoi gipergastrinemii na bazal'nu shlunkovu sekretsiyu u shchuriv . Visn. problem biologii i meditsini. 2007. Vip. 3. p. 38-43.
    6.  
  6. Boyum A. Separation of leucocytes from blood and bone marrow . Scand. J.Clin. Lab. Invest. 1968. 21. P. 28-30.
    7.  
  7. Brett S. Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness . Critical Care. 2005. 9. P. 45-50.  CrossRef PubMed PubMedCentral
    8.  
  8. Content J. Mechanisms of induction and action of interferons . Verh. K. Acad. Geneeskd. Belg. 2009. 71, N 1-2. P. 51-71.  PubMed
    9.  
  9. Creutzfeldt W., Lamberts R. Is hypergastrinaemia dangerous to man? . Scand. J. Gastroenterol. 1991. 180. P. 179-191. CrossRef  
  10. Jain R.N., Al-Menhali A.A., Keeley Th.M, Ross T.S, Chew C.S. and Samuelson L.C. Hypergastrinemia and hypertrophic gastritis in Hip1r-de?cient mice . The FASEB J. 2007. 21. P. 925-930.
    11.  
  11. Kang W., Rathinavelu S., Samuelson L.C., Merchant J.L. Interferon gamma induction of gastric mucous neck cell hypertrophy . Lab. Invest. 2005. 85, N 5. P. 702-715. CrossRef PubMed
    12.  
  12. Korotkyi O., Karpovets T., Pilipenko S., Beregova T., Ostapchenko L. Proin?ammatory cytokines concentrations in blood serum of rats with the long-term suppression of gastric secretion of hydrochloric acid in conditions of injection of probiotic . 35th FEBS Congress Goteborg (Gothenburg), Sweden, June 26 July 1, 2010. P. 65.
    13.  
  13. Nikolskaya V.V., Nikolskii I.S., Shulkevich T.P. Stimulation of the interferon synthesis in mice with various tumors by the thymic factor thymoinduction . 3rd Balkan Congress of Immunology. Athens, Greece, 2001. P. 77.
    14.  
  14. Prewett E.J., Hudson M., Nwokolo C.U., Sawyerr A.M., Pounder R.E. Nocturnal intragastric acidity during and after a period of dosing with either ranitidine or omeprazole . Gastroenterology. 1991. 100, N 4. P. 873-877. CrossRef  
  15. Takaoka A., Yanai H. Interferon signalling network in innate defence . Cell. Microbiol. 2006. 8, N 6. P. 907-922. CrossRef PubMed
    16.  
  16. Uematsu S., Akira S. Toll-like receptors and type I interferons . J. Biol. Chemistry. 2007. 282, N . 21. P. 15319-15324.
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