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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(1): 84-88


The interferon production by rat spleen and thymus lymphocytes in condititons of hypoacidity

Kompanets' IV, Korotkyĭ OH, Nikols'ka VV, Ostapchenko LI, Pylypenko SV

    SSC Institute of Biology Taras Shevchenko NationalMedical University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.01.084

Abstract

The interferon production by rat spleen and thymus lymphocytes in conditions of gastric juice hypoacidity, evoked by 28 days of omeprazole treatment, was studied. It was shown that the spontaneous and induced by PHA and cycloferone interferon titer increases in thymocyte and sleenocyte cell cultures under the action of omeprazole. This effect was more expressed in thymocytes. It might be a result of stimulation of interferon secretion by lymphoid cells. Probably the interferon synthesis intensifies in conditions of hypoacidity. This effect may be considered as the reaction of immune system on inflammation in gastro-intestinal tract.

Keywords: interferon, lymphocytes, spleen, thymus, omeprazole, hypoacidity

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