Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(1): 47-55

Modulation of the effects of dexamethasone in rat skeletal muscle by testosterone

Trush VV, Soboliev VI

    Donetsk National University, Donetsk, Ukraine
DOI: https://doi.org/10.15407/fz59.01.047


Abstract

In experiments on young females white rats by means of methods of electromyography and ergography we investigated the efficiency of a testosterone-propionate for smoothing of negative effects of dexamethasone on skeletal muscle. It has been established that the chronic injection of dexamethasone causes the decreasing of amplitude of contraction of forward tibial muscle on 29.7-59.3% (after 5-25 injections) and the lengthening of the latent period of muscle's excitation on 18.5-16.5% (after 15-25 injections), whereas the complex application of testosterone and dexamethasone prevents the changing of these parameters. At the same time testosterone didn't provide the smoothing of negative influence of dexamethasone on muscle's resistance to fatigue development.

Keywords: dexamethasone, testosterone, skeletal muscle,solitary muscle’s contraction.

Full text: (PDF, in Ukrainian)

References

  1. Giniatullin A.R., Grishin S.N., Giniatullin R.A. Vliyanie gidrokortizona na moduliruyushchie effekti purinov v nervno-mishechnom soedinenii . Ros. fiziol. zhurn. im. I.M. Sechenova. 2000. 86, N 10. S. 1293-1299.
    2.  
  2. Dzamukov R.A., Valiullin V.V. Otvet skeletnih mishts na anabolicheskii steroid individualen i ne zavisit ot rezhima dvigatel'noi aktivnosti . Byul. eksperim. biologii i meditsini. 1999. N 8. S. 406-408.
    3.  
  3. Mak-Komas A.Dzh. Skeletnie mishtsi (stroenie i funktsii). K.: Olimp. lit-ra, 2001. 406 s.
    4.  
  4. Temin P.A., Gerasimova O.I. Steroidnie miopatii: Obzor . Zhurn. nevropatologii i psihiatrii im. S.S. Korsakova. 1980. N 11. S. 1734-1737.
    5.  
  5. Teppermen Dzh., Teppermen H. Fiziologiya obmena veshchestv i endokrinnoi sistemi: per. s angl. M.: Mir, 1989. 656 s.
    6.  
  6. Yakovlev N.N., Makarova T.N. Obzor: funktsional'naya i metabolicheskaya differentsiatsiya volokon skeletnih mishts . Fiziol. zhurn. SSSR im I.M. Sechenova. 1980. N 8. S. 1129-1144.
    7.  
  7. Bouzat C., Bouzat S., Barrantes F.J. Assigning function to residues in the acetylcholine receptor channel region . Mol. Membr. Biol. 1997. N 14. R. 167-177.
    8.  
  8. Bowes S.B., Jackson N.C., Papachristodoulou D. Effect of corticosterone on protein degradation in isolated rat soleus and extensor digitorum longus muscles . J. Endocrinol. 1996. N 3. R. 501-507.
    9.  
  9. Cheema I.R., Wadley A.M., Prospere V. Comparison of the effect of acute and chronic glucocorticoid excess on protein synthesis in rat skeletal muscles of different Kbre composition . Biomed. Lett. 1994. N 196. R. 303-310. 
    10.  
  10. Kaasik P., Seene T., Umnova M. The mechanism of action of glucocorticoids in the rat skeletal muscle . Balt. J. Lab. Anim. Sci. 2000. N 3-4. R. 185-193. 
    11.  
  11. Riso E.M. The effect of glucocorticoid myopathy, unloading and reloading on the skeletal muscle contractile apparatus and extracellular matrix . Dis. PhD of Exercise and Sport Sci.: 10.12.07. Tartu, Estonia, 2007. 114 p.
    12.  
  12. Savary I. I. Savary, E. Debras, D. Dardevet. Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats . Brit. J. Nutr. 1998. N 3. R. 297-304.
    13.  
  13. Sinha-Hikim I., Roth S.M. Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men . Amer. J. Physiol. Endocrinol. Metab. 2003. 285 (Jul., 1). P. E197-E205.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.