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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(2): 16-23


Cardioprotective effectsof the new fluorine-containing activatorof atp-dependent k-channels

R. B. Strutinskii, A. A. Moibenko, L. M. Yagupolskii, M. YA. Yuzkiv,L. I. Kvochina, A. Shish

    A.A.Bogomoletz Institute of PhysiologyNational Academy of Sciences of Ukraine, Kiev


Abstract

Effects of PF-10 the new fluorine-containing activator of ATP-dependent K-channels were investigated on the guinea-pig isolated heart. PF-10 enchanced myocardial contractility and decreased coronary vessels resistance in a dose-dependent manner. Low doses (10 mM/L, 1 mM/L) of PF-10 attenuates of the spontaneous alterations of heart rate, while high doses (0.1 mM/L) leds to these alterations. Previous activation of ATP-dependent K-channels by PF-10 has a cardioprotective effect during ischemia-reperfusion which a similar to the well-known phenomenon of ischemic preconditioning.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.