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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 89-97


Regulation of oocyte meiotic resumption in mammals

O.A.Shepel, T.V.Blashkiv, T.Yu.Voznesenska,R.I.Yanchiy

    O.O. Bogomolets Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv.


Abstract

Currently, the molecular mechanisms involved in induction of oocyte meiotic resumption in the pre-ovulatory follicle which may include (involve) the elimination of meiosis inhibiting factors and/or the accumulation or activation of oocyte matu­ration signals are actively studied. The present review sum­marizes the existing literature data regarding the participation of cyclic monophosphates (cAMP and cGMP), protein kinases (mitogen-activated protein kinase (MAPK), АІ, АІІ, В, С, G), epidermal-growth factors (EGF), EGF-like factors, mRNA EGF and EGF-like factors, ovarian steroid hormones and ste-rols, as well as transcription factors NF-kB and CREB (cAMP response element binding protein) in the regulation of mam­malian oocyte meiotic resumption. Such scheme of regulation of oocyte meiotic resumption is discussed (considered): the ac­tion of gonadotrophins, FSH and LH, causes increase the pro­duction of cAMP and subsequent activation of MAPK. cGMP (during follicular growth) can prevent untimely oocyte meiotic resumption up to ovulation (after LH surge, after increase in LH). FSH- and the LH -induced system of EGF, steroids and sterols are involved in MAPK activation. Whereas different FSH and LH effects on NO production in ovary are involved in the regulation of induction of oocyte meiotic resumption in mammals. The further research is needed to better understand the new important mechanisms that regulate diffcult aspects of oocyte meiotic maturation in mammals.

Keywords: oocyte, meiotic resumption, gonadotrophins,cyclic monophosphates, epidermal-growth factors, proteinkinases, steroids, sterols.

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