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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 75-80

Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats

Fedotova IuO, Ordian NE, Frolova HO, Soboliev VI.

  1. Laboratory of Neuroendocrinology of I.P.Pavlov Institute of Physiology, RAS, Snt-Petersburg, Russia
  2. Donetsk National University, Ukraine


The present work was devoted to the comparative analysis of infuence of chronic administration of 5-НТ2B/2C receptors agonist – m-CPP (0,5 mg/kg, i.p.) and 5-НТ2А/2C receptors antagonist – ketanserine (0,1 mg/kg, i.p.) for 14 days on the anxiety and depressive-like behavior in adult female rats. It was established that chronic ketanserine administration ren­dered antidepressive and anxiolytic effects in females during estrous and proestrous. M-CPP administration also resulted in antidepressive effect in estrous and proestrous. Also, it was noted defnite modulation of anxiety behavior in connection of ovary cycle phases in rats treated with m-CPP: at increased level of estrogens was anxiolytic effect while at reduced level of estrogen – anxiogenic effect. It is suggested the involvement of different subtypes of 5-HT receptors in the mechanisms of anxiety-depressive-like behavior at alterations of hormonal balance during ovary cycle. The data obtained indicate a close interaction between the ovary hormonal and serotonergic sys­tems of the brain in the mechanisms of anxiety and depression.

Keywords: m-CPP, ketanserine, anxiety, depression, ovarycycle, female rats.


  1. Veselovskaya AV, Shlyakhova AV Features of formation of the subordinate type of behavior of rats at agon-collision collisions . Physiol. . 2007. 53, N 2. P. 41-47. CrossRef  
  2. Voronina TA, Seredenin SB Methodical instructions for the study of tranquilizing (anxiolytic) action of pharmacological substances. In the book: A guide to experimental (preclinical) study of new pharmacological substances. M .: IIA Remedium, 2000. P. 126-130.
  4. Eshchenko ND Biochemistry of mental and nervous diseases. St. Petersburg: Publisher St. Petersburg, 2004. 200 p.
  6. Kareva EN, Oleynikova OM, Panov VA, Shimanovsky NL, Skvortsova VI Estrogens and the brain . Bulletin of the Russian Federation. AMS. 2012. N 2. P.48-59. CrossRef  
  7. Kirshenblatt J.D. Workshop on endocrinology. M .: Higher School, 1969. 255 p.
  9. Mosolov SN The modern stage of development of psychopharmacotherapy . Neurologist. psychiatry. 2002. 10. N 12-13. P. 560-565.
  11. Ordyan NE, Fedotova Yu.O. Effect of agonist and antagonist 5-HT1A-subtype of serotonin receptors on training in female rats during the sexual cycle . Journal. higher nervous activity of them. IP Pavlova. 2010. N 4. P.493-499.
  13. Sapronov NS, Fedotova Yu.O. Hormones of the hypothalamic-pituitary-ovarian system and brain. St. Petersburg: Formizdat, 2009. 592 p.
  15. Fedotova Yu.O. Effects of 5-HT1 and 5-HT2-serotonin receptor agonists on anxiety-depressive-like behavior of female rats . Experim. and a wedge. pharmacology. 2011. N 3. P.6-9.
  17. Amin Z., Epperson C.N. Effect of Estrogen-serotonin interactions on mood and cognition . Behav. Cogn. Neurosci. Rev. 2005. 4. P. 43-58. CrossRef PubMed
  19. Bethea C.L., Lu N.Z., Gundlan C., Streicher J.M Diverse actions of ovarian steroids in the serotonin neural system . Front. Neuroendocrinol. 2002. 23. P. 41-100. CrossRef PubMed
  21. Clayton A.H. Symptoms related to the menstrual cycle: diagnosis, prevalence, and treatment . J. Psychiatr. Pract. 2008. 14. P. 13-21. CrossRef PubMed
  23. Diaz-Veliz G., Alarcon T., Espinoza C., Dussaubat N., Mora S. Ketanserin and anxiety levels: infuence of gender, estrous cycle, ovariectomy and ovarian hormones in female rats . Pharmacol. Biochem. Behav. 1997. 58. P. 637-642. CrossRef  
  24. Lasiuk G.C., Hegadoren K.M. The effects of estradiol on central serotonergic systems and its relationship to mood in women . Biol. Res. Nurs. 2007. 9. P. 147-160. CrossRef PubMed
  26. Markou A., Duka T., Prelevic G.M. Estrogens and brain function . Estrogens and brain function. Hormones. 2005. 4. P. 9-17. CrossRef PubMed
  28. Olie J. P., Costa E Silva J., Macher J. P. Neuroplasticity: a new approach to the pathophysiology of depression. . London UK: Science Press, 2004. 75 p.
  30. Pigott T.A. Anxiety disorders in women . Psychiatry Clin. North Am. 2003. 26. P. 621-672. CrossRef  
  31. Porsolt R.D.G., Anton G., Blavet N., Jalfre M. Behav­ioural despair in rats: a new model sensetive to antide-pressant treatment . Eur. J. Pharmacol. 1978. 47. P. 379-391. CrossRef  
  32. Rapkin A.J., Winer S.A. The pharmacologic manage­ment of premenstrual dysphoric disorder . Expert. Opin. Pharmacol. 2008. 9. P. 429-445. CrossRef PubMed
  34. Rubinow D.R., Schmidt P.J. Menstrual cycle-related and perimenopause-related affective disorders . Psychoneu-roendocrinology The Scientifc Basis of Clinical Practice Eds. . Wolkowitz O., Rothschild A. . Washington-Lon­don. Amer. Psychiatric. Publ. Inc., 2003. P. 245-280.
  36. Rybaczyk L.A., Bashaw M.J., Pathak D.R., Moody S.M., Gilders R.M., Holzschu D.L. An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology . BMC Womens Health. 2005. 5. P. 5-12. CrossRef PubMed PubMedCentral
  38. Sell S.L., Craft R.M., Seitz P.K., Stutz S.J., Cunningham K.A., Thomas M.L. Estradiol-setraline synergy in ovari-ectomized rats . Psychoneuroendocrinol. 2008. 33. P. 1051-1060. CrossRef PubMed
  40. Touxefs D.J., Myers K.M., Davis M. The effect of gonadal hormones and gender on anxiety and emotional learning . Horm. Behav. 2006. 50. P. 539-549. CrossRef PubMed

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