Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 75-80


Involvement of some subtypes of 5-HT[sub]2[/sub]-receptors in affective behaviour in female rats

Yu.O. Fedotova, N.E. Ordyan, G.O. Frolova,V.I. Sobolev

    Laboratory of Neuroendocrinology of I.P.Pavlov Institute of Physiology, RAS, Snt-Petersburg, Russia,Donetsk National University, Ukraine.


Abstract

The present work was devoted to the comparative analysis of infuence of chronic administration of 5-НТ2B/2C receptors agonist – m-CPP (0,5 mg/kg, i.p.) and 5-НТ2А/2C receptors antagonist – ketanserine (0,1 mg/kg, i.p.) for 14 days on the anxiety and depressive-like behavior in adult female rats. It was established that chronic ketanserine administration ren­dered antidepressive and anxiolytic effects in females during estrous and proestrous. M-CPP administration also resulted in antidepressive effect in estrous and proestrous. Also, it was noted defnite modulation of anxiety behavior in connection of ovary cycle phases in rats treated with m-CPP: at increased level of estrogens was anxiolytic effect while at reduced level of estrogen – anxiogenic effect. It is suggested the involvement of different subtypes of 5-HT receptors in the mechanisms of anxiety-depressive-like behavior at alterations of hormonal balance during ovary cycle. The data obtained indicate a close interaction between the ovary hormonal and serotonergic sys­tems of the brain in the mechanisms of anxiety and depression.

Keywords: m-CPP, ketanserine, anxiety, depression, ovarycycle, female rats.

References

  1. Веселовська О.В., Шляхова А. В. Особливості формування підлеглого типу поведінки щурів при агоні-стичних зіткненнях // Фізіол. журн. – 2007. – 53, № 2. – С. 41–47.
  2. Воронина Т.А., Середенин С.Б. Методические указания по изучению транквилизирующего (анксиолити-ческого) действия фармакологических веществ. – В кн.: Руководство по экспериментальному (доклиниче­скому) изучению новых фармакологических веществ. – М.: ИИА Ремедиум, 2000. – С. 126–130.
  3. Ещенко Н.Д. Биохимия психических и нервных болезней. – СПб: Изд-во ун-та СПб, 2004. – 200 с.
  4. Карева Е.Н., Олейникова О.М., Панов В.О, Шимановский Н.Л, Скворцова В.И Эстрогены и головной мозг // Вестник Рос. АМН. – 2012. – № 2. – С.48–59.
  5. Киршенблат Я.Д. Практикум по эндокринологии. – М.: Высшая школа, 1969. – 255 c.
  6. Мосолов С.Н. Современный этап развития психофармакотерапии // Невролог. психиатрия. – 2002. – 10. № 12–13. – С. 560–565.
  7. Ордян Н.Э., Федотова Ю.О. Влияние агониста и антагониста 5-НТ1А-подтипа серотониновых рецепторов на обучение у самок крыс в течение полового цикла // Журн. высш. нервн. деятельности им. И.П. Павлова. – 2010. – № 4. – С.493–499.
  8. Сапронов Н.С., Федотова Ю.О. Гормоны гипоталамогипофизарно-овариальной системы и мозг. – СПб: Формиздат, 2009. – 592 с.
  9. 9. Федотова Ю.О. Эффекты агонистов 5-НТ1 и 5-НТ2-серотониновых рецепторов на тревожно-депрессивно-подобное поведение самок крыс // Эксперим. и клин. фармакология. – 2011. – № 3. – С.6–9.
  10. 10. Amin Z., Epperson C.N. Effect of Estrogen-serotonin interactions on mood and cognition // Behav. Cogn. Neurosci. Rev. – 2005. – 4. – P. 43–58.
  11. Bethea C.L., Lu N.Z., Gundlan C., Streicher J.M Diverse actions of ovarian steroids in the serotonin neural system // Front. Neuroendocrinol. – 2002. – 23. – P. 41–100.
  12. Clayton A.H. Symptoms related to the menstrual cycle: diagnosis, prevalence, and treatment // J. Psychiatr. Pract. – 2008. – 14. – P. 13–21.
  13. Diaz-Veliz G., Alarcon T., Espinoza C., Dussaubat N., Mora S. Ketanserin and anxiety levels: infuence of gender, estrous cycle, ovariectomy and ovarian hormones in female rats // Pharmacol. Biochem. Behav. – 1997. – 58. – P. 637–642.
  14. Lasiuk G.C., Hegadoren K.M. The effects of estradiol on central serotonergic systems and its relationship to mood in women // Biol. Res. Nurs. – 2007. – 9. – P. 147–160.
  15. Markou A., Duka T., Prelevic G.M. Estrogens and brain function // Estrogens and brain function. Hormones. – 2005. – 4. – P. 9–17.
  16. Olie J. P., Costa E Silva J., Macher J. P. Neuroplasticity: a new approach to the pathophysiology of depression. // London UK: Science Press, 2004. – 75 p.
  17. Pigott T.A. Anxiety disorders in women // Psychiatry Clin. North Am. – 2003. – 26. – P. 621–672.
  18. Porsolt R.D.G., Anton G., Blavet N., Jalfre M. Behav­ioural despair in rats: a new model sensetive to antide-pressant treatment // Eur. J. Pharmacol. – 1978. – 47. – P. 379–391.
  19. 19. Rapkin A.J., Winer S.A. The pharmacologic manage­ment of premenstrual dysphoric disorder // Expert. Opin. Pharmacol. – 2008. – 9. – P. 429–445.
  20. 20. Rubinow D.R., Schmidt P.J. Menstrual cycle-related and perimenopause-related affective disorders // Psychoneu-roendocrinology The Scientifc Basis of Clinical Practice Eds. / Wolkowitz O., Rothschild A. // Washington-Lon­don. – Amer. Psychiatric. Publ. Inc., 2003. – P. 245–280.
  21. Rybaczyk L.A., Bashaw M.J., Pathak D.R., Moody S.M., Gilders R.M., Holzschu D.L. An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology // BMC Womens Health. – 2005. – 5. – P. 5–12.
  22. Sell S.L., Craft R.M., Seitz P.K., Stutz S.J., Cunningham K.A., Thomas M.L. Estradiol-setraline synergy in ovari-ectomized rats // Psychoneuroendocrinol. – 2008. – 33. – P. 1051–1060.
  23. Touxefs D.J., Myers K.M., Davis M. The effect of gonadal hormones and gender on anxiety and emotional learning // Horm. Behav. – 2006. – 50. – P. 539–549.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.