The present work was devoted to the comparative analysis of infuence of chronic administration of 5-НТ2B/2C receptors agonist – m-CPP (0,5 mg/kg, i.p.) and 5-НТ2А/2C receptors antagonist – ketanserine (0,1 mg/kg, i.p.) for 14 days on the anxiety and depressive-like behavior in adult female rats. It was established that chronic ketanserine administration ren­dered antidepressive and anxiolytic effects in females during estrous and proestrous. M-CPP administration also resulted in antidepressive effect in estrous and proestrous. Also, it was noted defnite modulation of anxiety behavior in connection of ovary cycle phases in rats treated with m-CPP: at increased level of estrogens was anxiolytic effect while at reduced level of estrogen – anxiogenic effect. It is suggested the involvement of different subtypes of 5-HT receptors in the mechanisms of anxiety-depressive-like behavior at alterations of hormonal balance during ovary cycle. The data obtained indicate a close interaction between the ovary hormonal and serotonergic sys­tems of the brain in the mechanisms of anxiety and depression.