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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 75-80


Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats

Fedotova IuO, Ordian NE, Frolova HO, Soboliev VI.

  1. Laboratory of Neuroendocrinology of I.P.Pavlov Institute of Physiology, RAS, Snt-Petersburg, Russia
  2. Donetsk National University, Ukraine
DOI: https://doi.org/10.15407/fz58.06.075

Abstract

The present work was devoted to the comparative analysis of infuence of chronic administration of 5-НТ2B/2C receptors agonist – m-CPP (0,5 mg/kg, i.p.) and 5-НТ2А/2C receptors antagonist – ketanserine (0,1 mg/kg, i.p.) for 14 days on the anxiety and depressive-like behavior in adult female rats. It was established that chronic ketanserine administration ren­dered antidepressive and anxiolytic effects in females during estrous and proestrous. M-CPP administration also resulted in antidepressive effect in estrous and proestrous. Also, it was noted defnite modulation of anxiety behavior in connection of ovary cycle phases in rats treated with m-CPP: at increased level of estrogens was anxiolytic effect while at reduced level of estrogen – anxiogenic effect. It is suggested the involvement of different subtypes of 5-HT receptors in the mechanisms of anxiety-depressive-like behavior at alterations of hormonal balance during ovary cycle. The data obtained indicate a close interaction between the ovary hormonal and serotonergic sys­tems of the brain in the mechanisms of anxiety and depression.

Keywords: m-CPP, ketanserine, anxiety, depression, ovarycycle, female rats.

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