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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 67-74


Blood plasma testosterone andbrain serotonin levels in aggressive and submissive rats of different age groups

L.D. Popova, I.M. Vasylyeva

    Kharkiv National Medical University, Ukraine.
DOI: https://doi.org/10.15407/fz58.06.067


Abstract

Correlation between the level of testosterone in blood plasma and serotonin content in hippocampus and frontal cortex was investigated in aggressive and submissive rats of different age groups. Dependence of the testosterone level on behavior type was found. The highest testosterone level was observed in aggressive animals. In submissive males we found considerable decrease of the serotonin level in frontal cortex and hippocampus as compared with balanced and aggressive ones. The positive correlation between testosterone and serotonin levels was shown in submissive and aggressive animals in contrast to the negative correlation in balanced males. The change in negative correlation between the testosterone and serotonin content into positive one in the aggregate with the decrease or the increase of testosterone level is likely to be one of the components in formation of submissive and aggressive (dominant) behavior type, respectively.

Keywords: serotonin, testosterone, submissive and aggressivemales, rats.

References

  1. Vasil'eva I.M., Popova L.D. Optimizatsiya viboru kontrolyu pri vikoristanni modeli "sensornogo kontaktu" . Eksperim. i klin. meditsina. 2010. 48, N 3. C. 37-40.
  2.  
  3. Zapadnyuk I.P., Zapadnyuk V.I., Zahariya E.a., Zapadnyuk B.V. Laboratornie zhivotnie. K.: Vischa shkola, 1983. 383 s.
  4.  
  5. Adamec R., Burton P., Blundell J., Murphy D.L., Holmes A. Vulnerability to mild predator stress in serotonin transporter knockout mice . Behav. Brain. Res. 2006. 170. P. 126-140. CrossRef PubMed
  6.  
  7. Albert P.R., Francois B.L., Millar F.M Transcriptional dysregulation of 5-HT 1A autoreceptors in mental illness . Mol Brain. 2011. 4. P. 21. CrossRef PubMed PubMedCentral
  8.  
  9. Briley M., Moret C. Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors / Neuropsychiatr. Dis. Treat. 2010. 6. P. 647-655. CrossRef PubMed PubMedCentral
  10.  
  11. Brunner H.G., Nelen M., Breakefeld X.O., Ropers H.H., van Oost B.A. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase . Science. 1993. 262. P. 578-580. CrossRef PubMed
  12.  
  13. de Boer S. F., Koolhaas J. M. 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin defciency hypothesis . Eur. J. Pharmacol. 2005. 526, N 1-3. P. 125-139. CrossRef PubMed
  14.  
  15. Carroll J.C., Boyce-Rustay J.M., Millstein R., Yang R., Wiedholz L.M., Murphy D.L., Holmes A. Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice . Behav. Genet. 2007. 37. P. 214-222. CrossRef PubMed
  16.  
  17. Dranovsky A., Hen R. Hippocampal neurogenesis: regulation by stress and antidepressants . Biol. Psychiatry. 2006. 59. P. 1136-1143. CrossRef PubMed
  18.  
  19. Dubrovina N.I., Popova N.K., Gilinskii M.A., Tomilenko R.A., Seif I. Acquisition and extinction of a conditioned passive avoidance refex in mice with genetic knockout of monoamine oxidase . Neurosci. Behav. Physiol. 2006. 36. P. 335-339. CrossRef PubMed
  20.  
  21. Dulawa S.C., Holick K.A., Gundersen B., Hen R. Effects of chronic fuoxetine in animal models of anxiety and depression . Neuropsychopharmacology. 2004. 29. P. 1321-1330. CrossRef PubMed
  22.  
  23. Ferris C. F., Delville Y. Vasopressin and serotonin interactions in the control of agonistic behavior. Psychoneuroen-docrinology. 1994. 9, N 5-7. P. 593-601. CrossRef  
  24. Fox M.A., Andrews A.M., Wendland J.R., Lesch K.P., Holmes A., Murphy D.L. A pharmacological analysis of mice with a targeted disruption of the serotonin transporter . Psychopharmacology (Berl). 2007. 195. P. 147-166. CrossRef PubMed
  25.  
  26. Hackler E.A., Airey D.C., Shannon C.C., Sodhi M.S., Sanders-Bush E. 5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice . Neurosci. Res. 2006. 55. P. 96-104. CrossRef PubMed
  27.  
  28. Haller J., Kruk M.R. Normal and abnormal aggression: human disorders and novel laboratory models . Neurosci. Biobehav. Rev. 2006. 30, N 3 P. 292-303. CrossRef PubMed
  29.  
  30. Hariri A.R, Holmes A. Genetics of emotional regulation: the role of the serotonin transporter in neural function . Trends Cogn. Sci. 2006. 10. P. 182-191. CrossRef PubMed
  31.  
  32. Herman J.P., Ostrander M.M., Mueller N.K., Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis . Prog. Neuropsychopharmacol. Biol. Psychiatry. 2005. 29. P. 1201-1213. CrossRef PubMed
  33.  
  34. Herman J.P., Mueller N.K. Role of the ventral subiculum in stress integration . Behav. Brain. Res. 2006. 174. P. 215-224. CrossRef PubMed
  35.  
  36. Holmes A. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease . Neurosci. Biobehav. Rev. 2008. 32, N 7. P. 1293-1314. CrossRef PubMed PubMedCentral
  37.  
  38. Keck M.E., Sartori S.B., Welt T., Muller M.B., Ohl F., Holsboer F., Landgraf R., Singewald N. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment . J. Neurochem. 2005. 92. P. 1170-1179. CrossRef PubMed
  39.  
  40. Kubala R.H., McGinnis M.Y., Anderson G.M., Lumia A.R. The effects of an anabolic androgenic steroid and low serotonin on social and non-social behaviors in male rats . Brain Res. 2008. 1232, N26. P. 21-29. CrossRef PubMed
  41.  
  42. Kudryavtseva N.N. The sensory contact model for the study of aggressive and submissive behaviors male mice . Aggres. Behav. 1991. 17, N 5. P.285-291. CrossRef  
  43. Kulikov a.V., Osipova D.V., Naumenko V.S., Popova N.K. Associatiation betven Tph 2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains . Genes. Brain. Behavior. 2005. 4, N 8. P. 482-485. CrossRef PubMed
  44.  
  45. Lee S., Jeong J., Kwak Y., Park S.K. Depression research: where are we now? . Mol. Brain. 2010. 3. P. 8. CrossRef PubMed PubMedCentral
  46.  
  47. Lumia A.R., McGinnis M.Y. Impact of anabolic androgenic steroids on adolescent males . Physiol Behav. 2010. 100, N 3. P. 199-204. CrossRef PubMed
  48.  
  49. Mathews T.A., Fedele D.E., Coppelli F.M., Avila A.M., Murphy D.L., Andrews A.M. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression . J. Neurosci. Methods. 2004. 140. P.169-181. CrossRef PubMed
  50.  
  51. Mc Devitt R.A., Neumaier J.F. Regulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspective . J. Chem. Neuroanat. 2011. 41, N 4. P. 234-246. CrossRef PubMed PubMedCentral
  52.  
  53. Millan M.J. The neurobiology and control of anxious states . Prog. Neurobiol. 2003. 70. P. 83-244. CrossRef  
  54. Morikawa H., Manzoni O.J., Crabbe J.C., Williams J.T. Regulation of central synaptic transmission by 5-HT(1B) auto- and heteroreceptors . Mol. Pharmacol. 2000. 58. P. 1271-1278. CrossRef PubMed
  55.  
  56. Neumann I.D., Alexa H. Veenema, Beiderbeck D.I. Aggression and anxiety: Social sontext and neurobiological links . Front. Behav. Neurosci. 2010. N 4. P. 1-12.
  57.  
  58. Oquendo M.A., Mann J.J. The biology of impulsivity and suicidality . Psychiatr. Clin. North. Am. 2000. 23, N 1. P. 11-25. CrossRef  
  59. Parker K.J., Schatzberg A.F., Lyons D.M. Neuroendocrine aspects of hypercorticolism in major depression . Horm. Behav. 2003. 43. P. 60 66. CrossRef  
  60. Popova N.K., Kulikov a.V., Nikulina E.M., Kozlachkova E.Y., Maslova G.B. Serotonin metabolism and serotinergic receptors in Norway rats selected for low aggressiveness to man . Aggressive Behav. 1991. 14. P. 207 213. CrossRef  
  61. Popova N.K., Vishnivetskaya G.B., Ivanova E.A., Skrins-kaya J.A., Seif I. Altered behavior and alcohol tolerance in transgenic mice lacking MAO A: a comparison with effects of MAO A inhibitor clorgyline . Pharmacol. Biochem. Behav. 2000. 67. P. 719-727. CrossRef  
  62. Popova N.K. From gene to aggressive behavior: the role of brain serotonin . Neurosci Behav Physiol. 2008. 38, N 5. P. 471-475. CrossRef PubMed
  63.  
  64. Ressler K.J, Nemeroff C.B. Role of serotonergic and nor-adrenergic systems in the pathophysiology of depression and anxiety disorders . Depress Anxiety. 2000. 12, Suppl. 1. P. 2-19. CrossRef  
  65. Reul J.M., Holsboer F. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression . Curr Opin Pharmacol. 2002. 2. P. 23-33. CrossRef  
  66. Reznikov A.G., Nosenko N.D., Tarasenko L.V., Sinitsyn P.V., Lymareva A.A. Prenatal dexamethasone prevents early and long-lasting neuroendocrine and behavioral effects of maternal stress on male offspring . Fiziol. zhurn. 2008. 54, N 5. P. 28-39.
  67.  
  68. Roselli C.E., Lice M., Hurn H.D. Brain aromatization: classical roles and new perspectives . Semin. Reprod. Med. 2009. 27, N 3. P. 207-217. CrossRef PubMed PubMedCentral
  69.  
  70. Rot M., Mathew S.J., Charney D.S. Neurobiological mechanisms in major depressive disorder . CMAJ. 2009. 108, N 3 P. 305-313.
  71.  
  72. Schlumpf M., Lichtensteiger W., Langemann H., Waser P.G., Hefti F.A. Fluorometric micromethod for the simultaneous determination of serotonin, noradrenaline and dopamine in milligram amount of brain tissue . Biochem. Pharmacol. 1974. 23, N 17. P. 2337-2446. CrossRef  
  73. Summers C.H., Winberg S. Interactions between the neural regulation of stress and aggression . J. Exp. Biol. 2006. 209. P. 4581-4589. CrossRef PubMed
  74.  
  75. Torres G.E, Amara S.G. Glutamate and monoamine transporters: new visions of form and function . Curr. Opin. Neurobiol. 2007. 17. P. 304-312. CrossRef PubMed
  76.  
  77. Trillat A. C., Malagi? I., Scearce K., Pons D. Regulation of serotonin release in the frontal cortex and ventral hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo microdialysis studies . Neurochem. 1997. 69, N 5. P. 2019-2025. CrossRef  
  78. van Der Vegt B.J. Lieuwes N., Cremers T.I., de Boer S.F., Koolhaas J.M. Cerebrospinal fuid monoamine and metabolite concentrations and aggression in rats / Horm. Behav. 2003. 44, N 3. P. 199-208. CrossRef  
  79. Vitiello B., Stoff D.M. Subtypes of aggression and their relevance to child psychiatry . J. Am. Acad. Child Ado-lesc. Psychiatry. 1997. 36. P. 307-315. CrossRef PubMed
  80.  
  81. Weiser M.J., Goel N., Sandan U.S., Bale T.L., Handa R.J. Androgen regulation of corticotropin-releasing receptor 2 (CRHR2) mRNA expression and receptor binding in the rat brain . Exp. Neurol.- 2008. 214, N 1. P. 62-68. CrossRef PubMed PubMedCentral
  82.  
  83. Witte A.V., Fltsel A., Stein P., Savli M., Mien L.K., Wad-sak W., Spindelegger C., Moser U., Fink M., Hahn A., Mitterhauser M., Klitter K., Kasper S., Lanzenberger R. Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects. Hum Brain Mapp. 2009. 30, N 8. P. 2558-2570. CrossRef PubMed
  84.  
  85. Zhang X., Beaulieu J.M., Sotnikova T. D., Gainetdinov R.R., Caron M.G. Tryptophan hydroxylase-2 controls brain serotonin synthesis . Science. 2004. 305. P. 217. CrossRef PubMed
  86.  

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