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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 48-56


The role of nitric oxide and taurinein regulation of dogs gastricsecretory function

O.A. Grinchenko, P.I. Yanchuk

    Peter Bogach Institute of Physiology ESC «Institute ofBiology» National Taras Shevchenko University of Kyiv.


Abstract

The infuence of taurine and endogenous nitric oxide on the gastric secretion and secretory process alterations by taurine at the nitric oxide synthesis blockade was investigated in chronic experiments on dogs with gastric fstulas. We determined the intensity of gastric secretion during 1,5 hours and quantita­tive content of hydrochloric acid, pepsine, total proteins and adenile system components. The NO-synthase inhibition by L-NAME evoked an increase of secreted gastric juice volume stimulated by histamine by 160% (Р<0,001), the gastric acid content – by 156,4% (Р<0,001), pepsine content – by 184,1% (Р<0,001) as compared with control. Taurine increases the volume of gastric juice stimulated by histamine on 129,3% (Р<0,001), hydrochloric acid – by 151,4% (Р<0,001), pepsine – by 172,2% (Р<0,001), total proteins – by 60,5% (Р<0,001) as compared with control. Blockade of nitric oxide synthesis did not alter the effect of taurine on histamine gastric secretion. The present results suggest that the endogenous nitric oxide provides an inhibitory infuence on gastric secretion and did not participate in realization of regulatory effects of taurine on gastric secretory function.

Keywords: nitric oxide, taurine, gastric secretion, hydrochloricacid, pepsine.

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