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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 23-28


Citokin 's profile of mononuclearsat patients by myocardialin farction, complicated cardiacinsufficiencycitokin 's profile of mononuclearsat patients by myocardialin farction, complicated cardiacinsufficiency

T.I. Gavrilenko, A.N. Parkhomenko, N.A. Ryzhkova, S.N. Kozhukhov, L.V. Yakushko

    National Scientific Center ”M.D. Strazhesko Institute of Cardiology”, National Academy of Medical Sciences, Kyiv, Ukraine.
DOI: https://doi.org/10.15407/fz58.06.023

Abstract

Between the pro- and antiinfammatory components of the immune system there is a dynamic balance, violation of which is an important mechanism of development of many pathological states, in particular, cardiac insuffciency. The purpose of the work was a study of secretion of cytokines by mononuclears in patients under myocardial infarction, uncomplicated (1 group) and complicated (2 group) acute cardiac insuffciency, and determination of balance between pro-(TNF-a, IL-6, IL-8) and antiinfammatory (IL-10) factors in development of acute cardiac insuffciency in patients with myocardial infarction. The results indicate that in patients of group 1 there is initially a high level of both proinfammatory and antiinfammatory cytokines. After 10 days, we observed a decline in the IL-6 level and an increase in the TNF-a and IL-10 levels. In patients of group 2 we observed initially high levels of TNF-a and IL-6 and a reduced levels of IL-8 and IL-10, as compared to patients of group 1. In dynamics of supervision of this group, further increase of all proinfamma-tory cytokines and a decline of IL-10 was registered. Balance between the pro- and antiinfammatory cytokines refects the index of infammatory activity, determined by formula (TNF-a+IL-6+IL-8)/IL-10 and testifying that in patients of group 1 in the dynamics of treatment there is normalization of cytokin’s balance, accompanied by decline of the index, while in patients of group 2 the index rose at 10th day.

Keywords: mononuclears, cytokines, myocardial infarction,cardiac insufficiency.

References

  1. Pliska O.I., Lazorishinets' V.V., Zaharova V.P., Loskutov O.A., Truba Ya.P., Knishov G.V. Sertseva ne­dostatnist' zbil'shue kil'kist' uskladnen', ingibitori angiotenzinperetvoryuyuchogo fermentu zmenshuyut' . Fiziol.zhurn. 2006. 52, N2. S.95-96.
  2.  
  3. SHahnovich R.M., Basinkevich a.B. Markeri vospaleniya i OKS . Kardiologiya SND. 2005. 3. S.58-64.
  4.  
  5. Apostolakis S., Vogiatzi K., Amanatidou V., Spandidos D.A. IL-8 and cardiovascular disease . Cardiovasc. Res. 2009. 84. P.353-360. CrossRef PubMed
  6.  
  7. Bodi V., Sanchis J., Nunez J., Mainar L., Minana G., Benet I., Solano C., Chorro F.J., Llacer A. Uncontrolled immune response in acute myocardial infarction: unraveling the thread . Amer. Heart J. 2008. 156. P.1065-1073. CrossRef PubMed
  8.  
  9. Chavez-Sanchez L., Chavez-Rueda K., Legorreta-Haquet M.V., Zenteno E., Ledesma-Soto Y., Montoyo-Dias E., Tesoro-Cruz E., Madrid-Miller A., Blanco-Favela F. The activation of CD14, TLR4 and TLR2 by mmLDL induces IL-1, IL-6 and IL-10 secretion in human monocytes and macrophages . Lipid. Health. Dis. 2010. 9. P.117-119. CrossRef PubMed PubMedCentral
  10.  
  11. van Haelst P.L., Tervaert J.W., Bijzet J., Balje-Volkers C., May J.F., Langeveld B., Gans R.O. Circulating monocytes in patientes with acute coronary syndromes lack suffcient interleukin-10 production after lipopolysaccharide stimulation . Clin. Exp. Immunol. 2004. 138. P.364-368. CrossRef PubMed PubMedCentral
  12.  
  13. Han X., Kitamoto S., Lian Q., Boisvert W.A. Interleu-kin-10 facilitates both cholesterol uptake and effux in macrophages . J. Bio.l Chem. 2009. 284 (47). P.32950-32958.
  14.  
  15. Hung M.J., Cherng W.J., Hung M.Y., Wu H.T., Pang J.H. Interleukin-6 inhibits endothelial nitric oxide synthase activation and increases endothelial nitric oxide syntase binding to stabilized caveolin-1 in human vascular endothelial cells . J. Hypertens . 2010. 28 (5). P.940-951. CrossRef PubMed
  16.  
  17. Lee W.W., Marinelli B., van der Laan A.M., Sena B.F., Gorbatov R., Leuschner F., Dutta P., Iwamoto Y., Ueno T., Be-gieneman M.P., Niessen H.W., Piek J.J., Vinegoni C., Pittet M.J., Swirski F.K., Tawakol A., Carli M.D., Weissleder R., Nahrendorf M. PET/MRI of infammation in myocardial infarction. J. Amer. Coll. Cardiol. 2012. 59 (2). P.153-163. CrossRef PubMed PubMedCentral
  18.  
  19. Lee S.Y., Zaske A.M., Novellino T., Danila D., Ferrari M., Conyers J., Decuzzi P. Probing the mechanical properties of TNF-? stimulated endothelial cell with atomic force microscopy . Int. J. Nanomedicine. 2011. 6. P.179-195. CrossRef PubMed PubMedCentral
  20.  
  21. Manual of Clinical Laboratory Immunology/ Ed. Rose N.R., Macario E.C., Folds J.D., Lane H.C., Nakamura R.M. Washington: ASM PRESS, 1997. 1255 r.
  22.  
  23. Mehra V.C., Ramgolam V.S., Bender J.R. Cytokines and cardiovascular disease . J. Leukoc. Biol. 2005. 78. P.805-818. CrossRef PubMed
  24.  
  25. Methe H., Kim J.O., Kofer S., Weis M., Nabauer M., Koglin J. Expansion of circulating Toll-like receptor 4-positive monocytes in patientes with acute coronary syndrome . Circulation . 2005. 111. P.2654-2661. CrossRef PubMed
  26.  
  27. Potteaux S., Esposito B., van Oostrom O., Brun V., Ard-ouin P., Groux H., Tedgui A., Mallat Z. Leukocyte-derived interleucin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knokcout mice . Arterioscler Thromb. Vasc. Biol. 2004. 24 (8). P.1474-1478. CrossRef PubMed
  28.  
  29. Riese U., Brenner S., Docke W.D., Prosch S., Reinke P., Op-pert M., Volk H.D., Platzer C. Catecholamines induce IL-10 release in patientes suffering from acute myocardial infarction by transactivating its promoter in monocytic but not in T-cells . Mol. Cell. Biochem. 2000. 212. P.45-50. CrossRef PubMed
  30.  
  31. Schuett H, Luchtefeld M., Grothusen C., Grote K., Schief-fer B. How much is too much? Interleukin-6 and its signaling in atherosclerosis . Thromb. Haemost. 2009. 102 (2). P.215-222. CrossRef PubMed
  32.  
  33. Shantsila E., Lip G Monocytes in acute coronary syn-droms. Arterioscler. Thromb. Vasc. Biol . 2009. 29. P.1433-1438. CrossRef PubMed
  34.  
  35. Vaddi K., Nicolini F.A., Mehta P., Mehta J.L. Increased secretion of TNF-? and Interferon- by mononuclear leukocytes in patientes with ischemic heart disease . Circulation. 1994. 90. P.694-699. CrossRef PubMed
  36.  
  37. Wrigly B.J., Lip G.Y., Shantsila E. The role of monocytes and infammation in the pathophysiology of heart failure . Eur. J. Heart Fail. 2011. 13 (11). P.1161-1171. CrossRef PubMed
  38.  
  39. Wyss C.A., Neidhart M., Altwegg L., Spanaus K.S., Yo-nekawa K., Wischnewsky M.B, Corti R., Kucher N., Roff M., Eberli F.R., Amman-Vesti B., Gay S., Eckardstein A., Luscher Th., Maier W. Cellular actors, Toll-like receptors, and local cytokine profle in acute coronary syndromes . Eur. Heart J. 2010. 31. P.1457-1469. CrossRef PubMed
  40.  
  41. Zimmerman M.A., Reznikov L.L., Raeburn C.D., Selzman C.H. Interleukin-10 attenuates the response to vascular injury. J. Surg. Res. 2004. 121(2). P.206-213. CrossRef PubMed
  42.  

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