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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 23-28

Citokin 's profile of mononuclearsat patients by myocardialin farction, complicated cardiacinsufficiencycitokin 's profile of mononuclearsat patients by myocardialin farction, complicated cardiacinsufficiency

T.I. Gavrilenko, A.N. Parkhomenko, N.A. Ryzhkova, S.N. Kozhukhov, L.V. Yakushko

    National Scientific Center ”M.D. Strazhesko Institute of Cardiology”, National Academy of Medical Sciences, Kyiv, Ukraine.


Between the pro- and antiinfammatory components of the immune system there is a dynamic balance, violation of which is an important mechanism of development of many pathological states, in particular, cardiac insuffciency. The purpose of the work was a study of secretion of cytokines by mononuclears in patients under myocardial infarction, uncomplicated (1 group) and complicated (2 group) acute cardiac insuffciency, and determination of balance between pro-(TNF-a, IL-6, IL-8) and antiinfammatory (IL-10) factors in development of acute cardiac insuffciency in patients with myocardial infarction. The results indicate that in patients of group 1 there is initially a high level of both proinfammatory and antiinfammatory cytokines. After 10 days, we observed a decline in the IL-6 level and an increase in the TNF-a and IL-10 levels. In patients of group 2 we observed initially high levels of TNF-a and IL-6 and a reduced levels of IL-8 and IL-10, as compared to patients of group 1. In dynamics of supervision of this group, further increase of all proinfamma-tory cytokines and a decline of IL-10 was registered. Balance between the pro- and antiinfammatory cytokines refects the index of infammatory activity, determined by formula (TNF-a+IL-6+IL-8)/IL-10 and testifying that in patients of group 1 in the dynamics of treatment there is normalization of cytokin’s balance, accompanied by decline of the index, while in patients of group 2 the index rose at 10th day.

Keywords: mononuclears, cytokines, myocardial infarction,cardiac insufficiency.


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