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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(6): 3-8


Increase in the sensitivityof the mitochondrial permeabilitytransition pore opening to ca[sup]2+[/sup] inheart of spontaneous hypertensive rat

N.A. Strutynska, N.A. Dorofeeva, G.L. Vavilova,V.F. Sagach

    O.O. Bogomolets Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv.


Abstract

In experiments vitro on the mitochondria isolated from adult and spontaneous hypertensive rat hearts, we studied the sensitivity of the mitochondrial permeability transition pore (mPTP) opening to its natural inductor, Ca2+. We observed an increase in the sensitivity of mPTP opening to Ca2+ in the heart of spontaneous hypertensive rats because of a decrease in the threshold concentration of this ion required for organ-elles swelling by two orders of magnitude. It was shown that the classical inhibitor mPTP cyclosporin A (10-5 mol / L) partially (54%) inhibited of mPTP opening in the heart of these animals, indicating that the presence in the heart of these animals of cyclosporin A-insensitive component of the mPTP. The results of our observations give reason to conclude that the hypertensive state of the organism is associated with mitochondrial dysfunction, which is characterized, in par­ticular, by an increased sensitivity mPTP to Ca2+, eliciting a widespread tissue damage and diseases of the cardiovascular system, especially hypertension.

Keywords: mitochondrial permeability transition pore, heart,hypertension, rat.

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