Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(5): 78-85

Genetic aspects of indeterministic effects of ionizing radiation

Tkachenko MM, Liubarets TF.

    A.A. Bogomoletz National Medical University, Kyiv;SI “National Research Center for Radiation Medicine NAMS of Ukraine”, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz58.05.078


Abstract

The theoretical and practical data on damage of сell genome using modern investigating methods in persons exposed to ion­izing radiation are revealed. The mechanisms of cell genome damage as a basis of cancerogenesis in exposed to different doses of ionizing radiation persons are analyzed.

Keywords: genes, indeterministic effects, ionizing radiation,mutations, chromosomes.

Full text: (PDF, in Ukrainian)

References

  1. Bezlepkin VG, Gaziev AI Induced instability of the genital genome of animals by mini- and microsatellite sequences . Radiats. biology. Radioecology. 2001. 41, No. Z. P. 475-488.
    2.  
  2. Burlakova EB, Mikhailov VF, Mazuryk VK The system of redox homeostasis in radiation-induced genome instability . Ibid. P. 489-499.
    3.  
  3. Veremeeva GA Influence of chronic radiation exposure on the level of somatic mutations in human peripheral blood cells in the long term: Dis. … To the biol. Sciences: 03.00.01. Chelyabinsk, 1996. 111 p.
    4.  
  4. Vilinska MA, Dybsky SS, Dybskaya OB Detection of chromosomal instability in the offspring of parents irradiated as a result of the Chornobyl catastrophe by two-term cultivation of peripheral blood lymphocytes . Cytology and genetics. 2005. 39, N 4. P. 32-40.
    5.  
  5. Vorobtsova IE Features of the offspring of irradiated biological objects . Med. radiology. 1974. N 11. P. 76-83.
    6.  
  6. Vorobtsova IE Somatic and genetic consequences of radiation action (comparative aspect) . Radiats. biology. Radioecology. 1991. 31, No. 4. P. 568-570.
    7.  
  7. Vorobtsova IE, Vorobieva MV Radiosensitivity of chromosomes in children whose parents underwent antitumor X-ray chemotherapy . Byul. experiment. biology and medicine. 1992. N 12. P. 655-657.
    8.  
  8. Dudochkina NE Cytogenetic study of cultures of human peripheral blood lymphocytes in the long term after acute external radiation: Dis. Dr. med. Sciences: 03.00.01. M., 2009. 196 p.
    9.  
  9. VD Zhestynikov, OA Igusheva Relationship of transcription and repair of radioinduced DNA damage . Radiats. biology. Radioecology. 1997. 37, No. 4. P. 549-553.
    10.  
  10. Zamulaeva I.A. Gene mutations in human somatic cells in vivo: radiobiological regularities: Dis. Dr. Biol. Sciences: 03.00.01. Obninsk, 2003. 282 p.
    11.  
  11. Zamulaeva IA, Salnikova LE, Ivanova TI The conjugation of TCR mutations with DNA polymorphism in women living in radionuclide-contaminated regions of the Russian Federation . Radiats. biology. Radioecology. 2009. 49, No. 4. P. 389-396.
    12.  
  12. Kozionova OS Frequency of mutations in minisatellite DNA loci in residents of coastal villages of the Techa river that have been exposed to chronic radiation: Dis. ... to the biol. Sciences: 03.00.01. M., 2006. 138 p.
    13.  
  13. Mazurik VK, Mikhailov VF Radiation-induced genome instability: a phenomenon, molecular mechanisms, pathogenetic significance . Radiats. biology. Radioecology. 2001. 41, No. Z. P. 272-289.
    14.  
  14. Mikhailova G.F. Analysis of the results of cytogenetic studies of the population living in radioactively contaminated territories after the Chernobyl accident: Dis. ... Dr. Biol. Sciences: 03.00.01. Obninsk, 2009 . 203 p.
    15.  
  15. Misharina Zh.A. Somatic and genetic effects in children at the end of the line in the internal fetal inspection of the accident at the Chornobilsky AES: Abstract. dis.  cand. biol. Sciences: 03.00.15. K., 2006 .-- 12 p.
    16.  
  16. Nikanorova E.A. Reparative DNA synthesis and cytogenetic effects in peripheral blood cells of atomic professionals in the long term: Dis. ... biol. Sciences: 03.00.01. Sarov, 2006 .-- 113 p.
    17.  
  17. Pilinskaya M.A., Shemetun A.M., Dybsky S.S. Results of 14-year cytogenetic monitoring of priority observation contingents affected by the factors of the accident at the Chernobyl nuclear power plant . Vestnik Ros. Acad. honey. sciences. 2001. No. 10. P. 80-84.
    18.  
  18. Rivkind N.B., Staritsina L.P., Skvortsova G.V. Multi-aberrant cells in participants in the aftermath of the Chernobyl accident . Therap. archive. 1996. No. 7. P. 77-79.
    19.  
  19. Saenko A.S., Zamulaeva I.A., Smirnova S.G. et al. Determination of mutation frequency by glycophorin A and T-cell receptor loci: examination of the liquidators of the Chernobyl accident . Radiats. biology. Radioecology. 1998. 38, No. 2. P. 181-185.
    20.  
  20. Salnikova L.E., Chumachenko A.G., Vesnina I.N. Analysis of the genotypic dependence of chromosomal aberration frequencies in human lymphocytes upon irradiation in vivo and in vitro . Ibid. 2010. 50, No. 3. P. 340-344.
    21.  
  21. Sevankaev A.V., Shkavrova T.G., Potetnya O.I. Comparative study of structural and genetic somatic mutations in workers of nuclear chemical enterprises. I. The study of unstable and stable chromosomal aberrations . Ibid. 2005. 45, No. 2. P. 149-161.
    22.  
  22. Stepanova E.I., Misharina Zh.A., Vdovenko V.Yu. Long-term cytogenetic effects in children irradiated in utero as a result of the Chernobyl accident . Ibid. 2002. 42, No. 6. P. 700-703.
    23.  
  23. Suvorova L.A., Galstyan I.A., Nadezhina N.M. The condition of peripheral blood in the long-term consequences of acute radiation sickness . Honey. radiology and glad. security. 2007. 52, No. 4. P. 14-24.
    24.  
  24. Tsepenko V.V. Dynamics of cytogenetic disorders in children and adolescents living in areas contaminated with radionuclides after the accident at the Chernobyl nuclear power plant: Dis.  biol. Sciences: 03.00.01. M., 2004 .-- 114 p.
    25.  
  25. Shkavrova T.G. The study of unstable and stable chromosome aberrations in workers of nuclear chemical enterprises and persons with acute radiation sickness in the distant post-radiation period: Abstract. dis. ... biol. Sciences: 03.00.01. Obninsk, 2002 .-- 24 p.
    26.  
  26. Armour J.A.L., Brinkworth M.H., Kamischke A. Direct analysis by smallpool PCR of MS205 minisatellite mutation rates in sperm after mutagenic therapies . Mutat. Res. 1999. 444. P.73-80. CrossRef  
  27. Barber R., Plumb M.A., Boulton E. Elevated mutation rates in germ line of first- and second-generation offspring of irradiated male mice . Proc. Natl. Acad. Sci. USA. 2002. 99. P. 6877-6882. CrossRef PubMed PubMedCentral
    28.  
  28. Buard J., Vergnaud G. Complex recombination events at the hypermutable minisatellite CEBl (D2S90) . EMBO J. 1994. 13. P. 3203-3210. CrossRef PubMed PubMedCentral
    29.  
  29. Chadwick K.H., Seymour C., Barnhart B. Cell transformation and radiation-induced cancer. N.-Y.: Adam Higer, 1989. 236 c.
    30.   Coborukova A., Lukasova E., Kozubek S. The exchanging chromosome aberrations of human peripheral limphocytes after gamma-irradiated . Int. J. Radiat. Biol. 2001. 77, N 4. P. 419-429 CrossRef PubMed  
  30. Dubrova Y.E. Radiation-Induced Mutation at Tandem Repeat DNA loci in the mouse germline: spectra and doubling doses . Rad. Res. 2005. 163. P. 200-207. CrossRef PubMed
    31.  
  31. Dubrova Y.E., Jeffreys A.J., Malashenko A.M. Mouse minisatellite mutations induced by ionizing radiation . Nat. Genet. 1993. 5. P. 92-94. CrossRef PubMed
    32.  
  32. Dubrova Y.E., Nesterov V.N., Krouchinsky N.G. Further evidence for elevated human minisatellite mutation rate in Belarus eight years after Chernobyl accident . Mutat. Res. 1997. 381. P. 267-278.
    33.  
  33. Dubrova Y.E., Grant G., Chumak A.A. Elevated minisatellite mutation rate in the post-chernobyl families from Ukraine . Amer. J. Hum. Genetics. 2002. 71. P. 801-809. CrossRef PubMed PubMedCentral
    34.  
  34. Friedberg E.C., Walker G.C., Siede W. DNA Repair and mutagenesis. ASM Press: Washington, DC. 1995.  P.59-61.
    35.  
  35. Harms-Ringdahl M. Some aspects on radiation induced transmissible genomic instability . Mutat. Res. 1998.  404. P. 27-33. CrossRef  
  36. Ivanov V., Praskova L., Mileva M.et al. Spontaneous chromosomal aberration levels in human peripheral lymphocytes . Ibid. 1978. 52, N 3. P. 421-426. CrossRef  
  37. Kennedy A.R., Cairns J., Little j.B. Timing of the steps in transformation of C3H 10T1. 2 cells by X-irradiation . Nature. 2005. 307. P. 85-86. CrossRef PubMed
    38.  
  38. Krolevski B., Little J.B. Alterations if mdm2 gene in Xray transformed mouse 10T1. 2 cell clones . Int. J. Oncol. 1995. 6. P. 1123-1127. CrossRef PubMed
    39.  
  39. Kyoizumi S., Nakamura N., Takebe H. Frequency of variant erythrocytes at the glycophorin-A locus in two Bloom's syndrome patients . Mutat. Res. 1989. 214. P.215-222. CrossRef  
  40. Little J.B. The revelance of cell transformation to carcinogenesis in vivo. Low dose radiation biological basis on risk assessment . Eds. K.F. Baverstock, J.W. Strather. London: Tailor and Francis, 1989. P. 396-413.
    41.  
  41. Little J.B. Radiation-induced genomic instability . Int. J. Radiat. Biol. 1998. 74. N 6. P. 663-671. CrossRef PubMed
    42.  
  42. Lloyd D.C., Purrott R.J., Reeder E.J. The incidence of unstable chromosome aberrations in peripheral blood lymphosytes from unirradiated and occupationally exposed people . Mutat. Res. 1980. 72. P. 523-532. CrossRef  
  43. Mukai T., Cockerman C.C. Sponteneous mutation rate at enzyme loci in Drosophila melanogaster . Proc. Natl. Acad. Sci. USA. 1977. 74. P. 2514-2517. CrossRef PubMed PubMedCentral
    44.  
  44. Pampfer S., Streffer C. Increased chromosome alteration levels in cells from mouse fetus after zygote X-irradiation . Int. J. Rad. Biol. 1989. 55. P. 85-92. CrossRef PubMed
    45.  
  45. Pierce D., Shimizu Y., Preston D. Studies of the mortality of atomic bomb survivors . Rad. Res. 1996. N 146. P. 1-27. CrossRef PubMed
    46.  
  46. Pilinskaya M.A., Dibskiy S.S., Shemetun Y.V. Chromosome instability in children with thyroid pathology born to irradiated parents due to Chernobyl accident . Europ. J. of Human Genetics. 2005. 13, Suppl. 1. P. 146.
    47.  
  47. Seifert A.M., Bradley W.C., Messimg K. Exposure of nuclear medicine patients to ionizing radiation is associated with rises in HPRT mutation frequency in peripheral T-lymphocytes . Mutat. Res. 1987. 191. P. 57-63. CrossRef  
  48. Tkachenko M.N., Kotsjuruba A.V., Bazilyuk O.V. et al. Vascular reactivity and metabolism of the reactive forms of oxygen and nitrogen: effects of low doses of radiation . Int. J. Lov. Radiat. 2011. 8, P. 107-121. CrossRef  
  49. Vorobtsova I.E. Increased cancer risk as a genetic effect of ionizing radiation . In.: N.P. Napalkov, J.M. Rice, L. Tomatis, H. Yamasaki (Eds.). IARC, Lyon. 1989. N 96. R. 389-401.
    50.  
  50. Watson G.E., Lorimore S.A., Wright E.G. Long term in vivo transmission of alpha-particle-induced chromosome instability in murine hemopoietic cells . Int. J. Radiat. Biol. 1996. 69. P. 175-182. CrossRef PubMed
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.