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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(5): 65-69


Рrofile of proinflammatory cytokinesin type 1 diabetes mellitus

Y. Kyiak, N. Fartushok, Y. Onyschuk, Y. Fedevych,G. Bashta

    Danylo Halytskyi Lviv National Medical University,Department of Family Medicine and Biological Chemistry.


Abstract

The study involved 70 patients with type 1 diabetes who were under medical care in the clinical city hospital. Patients were divided into two groups: group I included patients with severe form of diabetes with complications and group II included patients without complications. The cytokine profle in the diabetes mellitus patients was investi­gated. The study showed that all indices of proinfammatory cytokines in patients of both groups were higher than in control healthy subjects. The positive correlation between the level of proinfammatory cytokinеs in blood and severity of the course of disease was revealed.

Keywords: diabetes mellitus, proinflammatory cytokin„us,TNF-a, sTNF-R1, IL-1b, IL-6, IL-8.

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