Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(5): 28-35

Histostructural changes of rat cerebral cortex during hemorrhagic stroke modeling

Savos'ko SI, Chaĭkovs'kyĭ IuB, Pogoriela NKh, Makarenko OM

  1. O.O. Bogomoletz National Medical University, Kyiv, Ukraine
  2. O.O.Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv;Taras Shevchenko National University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz58.05.028


Abstract

Pathological changes during modeling of primary and secondary acute hemorrhagic stroke were studied in rats. We revealed differences in the activity of pharma­cological action of medications under condition of acute stroke. The action of medications increased viability of neurons in both hemispheres of rat cerebrum at a right-side primary and secondary hemorrhagic stroke. Following secondary stroke, the amount of degenera­tive neurons amounted 25,5±0,8 cells/mm2, following the action of cerebrolysin this value was 17,6±1,7 cells/ mm2 and after the action of cortexine and cerebral this value amounted 18,0±0,9 cells/mm2 and 10,7±0,4 cells/ mm2, respectively. In control animals the number of degenerative neurons did not exceed 2% and averaged 1,5±0,1 cells/mm2. Analysis of the morphological and statistical data showed that the most effective remedies under the primary and secondary hemorrhagic insult are cortexine and cerebral. Cerebral was found to be more effective.

Keywords: secondary stroke modeling, cerebral, cerebrolysin,cortexin.

Full text: (PDF, in Ukrainian)

References

  1. Vilensky B.S. Stroke: prevention, diagnosis and treatment. 2nd ed., Suppl. S. Pb .: Foliant, 2002. 397 p.
    2.  
  2. Vilensky B.S. Stroke. S.-Pb .: Med.inform.agency, 1995. 288 p.
    3.  
  3. Polishchuk ME, Danatsko VV, Zozulya IS, Kaminsky AO, Leshko MM, Somyk KI Intraventricular hemorrhages in the structure of hemorrhagic strokes . Probl. ecology. and honey. genetics and wedge. immunology. 2002. Issue 1 (40). P.69-74.
    4.  
  4. Krayneva VA, Seredenin SB Neuroprotective properties of afobazole in re-modeling hemorrhagic stroke in old rats . Byul. experiment. biology and medicine. 2010. 149, N 2. P.165-168. CrossRef PubMed
    5.  
  5. Zozulya A.I. Treatment of occlusive-stenotic processes of the internal carotid artery . Coll. Sciences. works of the KIAPO employees PL Shupik. 2004. Book. 1, no. 13. P.194-197.
    6.  
  6. Makarenko AN, Kositsyn NS, Pasikova NV, Svinov MM A method for modeling local hemorrhage in different brain structures in experimental animals . Journal. higher nerve. activities. 2002. 52, N 6. p. 765-768.
    7.  
  7. Romodanov AP, Pedachenko GA Brain hemorrhagic stroke. K .: Health, 1971 228 p.
    8.  
  8. Savosko SI, Tchaikovsky YB, Makarenko OM Patent for utility model of Ukraine N 64193. Method for modeling recurrent stroke in rats. Bul.N 20, 10. 25. 2011. P.5.143.
    9.  
  9. Haapasalo A., Sipola I., Larsson K., Akerman K. E. O., Stoilov P., Stamm S., Wong G., Castren E. Regulation of TrkB Surface Expressionby Brain-derived Neurotrophic Factor and Truncated TrkB Isoforms . J. Biol. Chem. 2002. 277, N 45. P. 43160-43167. CrossRef PubMed
    10.  
  10. Korhonen L. Anti-apoptotic proteins in nerve cell survival and neurodegeneration. In.: Acta Univ. Upsaliensis. 2002. 65 p.
    11.  
  11. Leker R.R., Teichner A., Grigoriadis N., Ovadia H., Brenneman D.E., Fridkin M., Giladi E., Romano J., Gozes I. NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death . Stroke. 2002. 33, N 4. P. 1085-1092. CrossRef PubMed
    12.  
  12. Makarenko A.N., Vasil'eva I.G. Neuroactivating mechanism of action of the new trophinotropic drug cerebral .Eksp. Klin. Farmakol. 2004. 67, N 4. P. 12-15.
    13.  
  13. Matsuzaki H., Daitoku H., Hatta M., Tanaka K., Fukamizu A. Insulin-induced phos phorylation of FKHR (Foxo1) targets to proteosomal degradation . PNAS. 2003. 100, N 20. P. 11285-11290. CrossRef PubMed PubMedCentral
    14.  
  14. Paxinos G., Watson C. The rat brain in stereotaxic coor­dinates, 2nd ed. Acad. Press, San Diego, 1986. 920 r.
    15.  
  15. Tak P.P., Firestein G.S. NF-kB: a key role in infammatory diseases . J. Clin. Invest. 2001. 107, N 1. P. 7-11. CrossRef PubMed PubMedCentral
    16.  
  16. Thippeswamy T., Howard M.R., Cosgrave A.S., Arora D.K., McKay J.S., Quinn J.P. Nitric oxide-NGF mediated PPTA. SP, ADNP, and VIP expression in the peripheral nervous system . J. Mol. Neurosc. 2007. 33, N 3. P. 268 277. CrossRef PubMed
    17.  
  17. Quintana F.J., Zaltzman R.,Fernandez-Montesinos R.,Herrera J.L., Gozes I.,Cohen I.R., Pozo D. NAP, a peptide derived from the activity-dependent neuroprotective protein, modulates Macrophage Function . Ann. N.Y. Acad. Sci. J. 2006. 1070. P. 500-506. CrossRef PubMed
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.