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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(5): 28-35

Histostructural changes of rat cerebral cortex during hemorrhagic stroke modeling

Savos'ko SI, Chaĭkovs'kyĭ IuB, Pogoriela NKh, Makarenko OM

  1. O.O. Bogomoletz National Medical University, Kyiv, Ukraine
  2. O.O.Bogomoletz Institute of Physiology, National Academyof Sciences of Ukraine, Kyiv;Taras Shevchenko National University, Kyiv, Ukraine


Pathological changes during modeling of primary and secondary acute hemorrhagic stroke were studied in rats. We revealed differences in the activity of pharma­cological action of medications under condition of acute stroke. The action of medications increased viability of neurons in both hemispheres of rat cerebrum at a right-side primary and secondary hemorrhagic stroke. Following secondary stroke, the amount of degenera­tive neurons amounted 25,5±0,8 cells/mm2, following the action of cerebrolysin this value was 17,6±1,7 cells/ mm2 and after the action of cortexine and cerebral this value amounted 18,0±0,9 cells/mm2 and 10,7±0,4 cells/ mm2, respectively. In control animals the number of degenerative neurons did not exceed 2% and averaged 1,5±0,1 cells/mm2. Analysis of the morphological and statistical data showed that the most effective remedies under the primary and secondary hemorrhagic insult are cortexine and cerebral. Cerebral was found to be more effective.

Keywords: secondary stroke modeling, cerebral, cerebrolysin,cortexin.


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