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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(5): 14-21


The polymorphism of matrixgla-protein gene in ischemicatherothrombotic stroke patients

V.Yu. Garbuzova, O.I.Matlaj, Y.A.Ataman,Ye.I.Dubovyk, А.A. Borodenko, O.A. Obukhova,A.V.Ataman

    Sumy State University.


Abstract

Matrix Gla protein (MGP) gene allelic polymorphism in 170 patients with ischemic atherothrombotic stroke (IATS) and in 124 healthy people was determined. It was shown that in patients with IATS interrelation of main homozygotes, heterozygotes and minor homozygotes is 61,2, 31,2, 7,6% for T-138 -> C (rs1800802) promoter polymorphism (in control – 59,7, 35,6, 4,8%, P=0,521 by x2-test); 35,9, 48,8, 15,3% for G-7 -> A (rs1800801) polymorphism of promotor (in control – 43,5, 50,0, 6,5%, P=0,051); 39,4, 48,8, 11,8% for Thr83 -> Ala (rs4236) polymorphism of 4 exon (in control – 34,7, 53,2, 12,1%, P=0,701). Signifcant differences in the frequency of G-7 -> A polymorphism between patients with IATS and control group were revealed only for women (P=0.022). The results obtained suggest that the A/A-variant of MGP gene promotor (G-7 -> A polymorphism) is associated with an increased risk of IATS in female persons in the Ukrainian population.

Keywords: matrix Gla protein, gene polymorphism, ischemicstroke.

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