Cardiohemodynamics and efficiency Frank-Starling mechanism in spontaneously hypertensive rats
Dorofeieva NO, Kuz'menko MO, Shimans'ka TV, Sagach VF.
Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz58.04.044
Abstract
We studied cardiohemodynamics and effciency Frank–Starling mechanism in 6-month-old spontaneously hypertensive rats (SHR) and age-matched Wistar rats, using pressure-volume (PV) conductance catheter system (Millar Instruments, Houston, TX) to evaluate systolic and diastolic function in vivo. Rats were anesthetized with urethane. Cardiohemodynamics analyzed using PVAN 3.6 (Millar Instruments). We found that systolic and diastolic function of the heart in spontaneously hypertensive rats were lower, than in controls. We have shown, inhibition of the effciency Frank–Starling mechanism, increasing arterial stiffness in spontaneously hypertensive rats. It’s shown, less effciency heart work, with more energy and more oxygen consumption in spontaneously hypertensive rats, may be associated with increasing arterial stiffness and decrease functional reserve of the heart.
Keywords:
heart, hypertension, cardiohemodynamics, Frank–Starling mechanism.
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