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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(4): 44-51


Cardiohemodynamics and efficiencyfrank–starling mechanism inspontaneously hypertensive rats

N.A. Dorofeyeva, M. A. Kuzmenko,T.V.Shimanskaya, V.F Sagach

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine


Abstract

We studied cardiohemodynamics and effciency Frank–Starling mechanism in 6-month-old spontaneously hypertensive rats (SHR) and age-matched Wistar rats, using pressure-volume (PV) conductance catheter system (Millar Instruments, Houston, TX) to evaluate systolic and diastolic function in vivo. Rats were anesthetized with urethane. Cardiohemodynamics analyzed using PVAN 3.6 (Millar Instruments). We found that systolic and diastolic function of the heart in spontaneously hypertensive rats were lower, than in controls. We have shown, inhibition of the effciency Frank–Starling mechanism, increasing arterial stiffness in spontaneously hypertensive rats. It’s shown, less effciency heart work, with more energy and more oxygen consumption in spontaneously hypertensive rats, may be associated with increasing arterial stiffness and decrease functional reserve of the heart.

Keywords: heart, hypertension, cardiohemodynamics, Frank–Starling mechanism.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.