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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(4): 13-20


Allelic polymorphism of Pro582-->Ser HIF-1alpha to exercise-induced hypoxia adaptation

S.B. Drozdovska, V.E. Dosenko, V.N. Ilyin

  1. National Institute of Physical Education and Sports of Ukraine, Kiev, Ukraine
  2. Institute of Physiology. A.A. Bogomolets National Academy of Sciences of Ukraine, Kiev, Ukraine
DOI: https://doi.org/10.15407/fz58.04.013

Abstract

The features of the distribution of allelic variants Pro582 - Ser polymorphism in HIF-1a gene in groups of athletes involved in sports, with different types of compensatory mechanisms of adaptation to hypoxic stress were investigated. During the study 191 highly qualifed athletes were examined. The control group included 260 subjects, not engaged in sports. The possibility of using this polymorphism as a molecular genetic marker of susceptibility to a variety of sports pursuits. The distribution of allelic variants of HIF-1a Pro582?Ser polymorphism of the residents of Ukraine was investigated. Found that the Pro/Pro genotype contributes to endurance performance. It is shown that the 582Ser gene HIF-1a - is a marker of predisposition to power sports. The result revealed that the frequency of Ser allele of HIF-1a (16% vs 7%, P=0.03) was signifcantly higher in the power-orientated athletes compared to endurance athletes. Key words: hypoxia-inducible factor 1a, HIF-1a, allelic polymorphism, exercise-induced hypoxia, muscle activity.

Keywords: hypoxia-inducible factor 1б, HIF-1б, allelicpolymorphism, exercise-induced hypoxia, muscle activity.

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