Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(4): 13-20

Allelic polymorphism of Pro582-->Ser HIF-1alpha to exercise-induced hypoxia adaptation

S.B. Drozdovska, V.E. Dosenko, V.N. Ilyin

  1. National Institute of Physical Education and Sports of Ukraine, Kiev, Ukraine
  2. Institute of Physiology. A.A. Bogomolets National Academy of Sciences of Ukraine, Kiev, Ukraine


The features of the distribution of allelic variants Pro582 - Ser polymorphism in HIF-1a gene in groups of athletes involved in sports, with different types of compensatory mechanisms of adaptation to hypoxic stress were investigated. During the study 191 highly qualifed athletes were examined. The control group included 260 subjects, not engaged in sports. The possibility of using this polymorphism as a molecular genetic marker of susceptibility to a variety of sports pursuits. The distribution of allelic variants of HIF-1a Pro582?Ser polymorphism of the residents of Ukraine was investigated. Found that the Pro/Pro genotype contributes to endurance performance. It is shown that the 582Ser gene HIF-1a - is a marker of predisposition to power sports. The result revealed that the frequency of Ser allele of HIF-1a (16% vs 7%, P=0.03) was signifcantly higher in the power-orientated athletes compared to endurance athletes. Key words: hypoxia-inducible factor 1a, HIF-1a, allelic polymorphism, exercise-induced hypoxia, muscle activity.

Keywords: hypoxia-inducible factor 1б, HIF-1б, allelicpolymorphism, exercise-induced hypoxia, muscle activity.


  1. Akhmetov II, Khakimullina AM, Lyubaeva EI, Vinogradova OL, Rogozkin VA Effect of HIF-1a gene polymorphism on human muscle activity . Bul. experiment. biology and medicine. 2008. 146, N 9. P. 327-329. CrossRef PubMed
  3. Drevytska TI Expression of the α-subunit of the hypoxia-inducible factor (HIF) gene, its allelic polymorphism under normoxic and hypoxic conditions. Avt-torf. diss. ... Ph.D. Sciences. K., 2010. 24 p.
  5. Kolchinskaya A.Z. On the classification of hypoxic states. In the book: Special and clinical physiology of hypoxic conditions. K .: Sciences. Opinion, 1979 Vol. 1 P.11-16.
  7. Mankovskaya IM, Moiseenko EV,. Dyachenko MP Features of restructuring of the functional respiratory system after a long stay in the Antarctic conditions . Fiziol. zh. 2005. 51, N 3. P.25-31.
  9. Moiseenko EV, Drevitskaya TI Dependence of dysadaptation disorders of functional systems of the organism on polymorphism of HIF-1a gene during long stay of a person in Antarctica . Fiziol. zh. 2008. 54, N 3 P. 65-73.
  11. Serebrovskaya TV,. Korkushko OV, Shatilo VB Individual features of human adaptation to periodic hypoxia: search for possible genetic mechanisms . Fiziol. zh. 2007. 53, No. 2. P.16-17.
  13. Filippov MM, Davidenko DN Physiological mechanisms of development and compensation of the state of hypoxia in the process of adaptation to muscular activity. St. Petersburg. Kiev: BPA. 2010. 260 p.
  15. Ameln H. Th. Gustafsson, C.J.Sundberg, K.Okamoto, E.Jansson, L. Poellinger, Yu. Makino Physiological ac­tivation of hypoxia inducible factor-1 in human skeletal muscle . The FASEB J. 2005. 19. R.1009-1011. CrossRef PubMed
  17. Bohuslavova R., Kolar F., Kuthanova L., Neckar J., Tichopad, Pavlinkova G. Gene expression profling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia . J.Appl. Physiol. 2010. 109. P. 1195 1202. CrossRef PubMed
  19. Cieszczyk P., Eider J., Arczewska A., Ostanek M., Leonska-Duniec A., Sawczyn S., Ficek K., Jascaniene N., Kotarska K., Sygit K. The HIF-1A gene Pro582Ser polymorphism in polish power-orientated athletes . Biol. Sport. 2011. 28, N 2. P.111-114. CrossRef  
  20. Doring F. Onur S., Fischer A., Boulay M.R., Perusse L., Rankinen T., Rauramaa R., Wolfarth B., Bouchard Claude. A common haplotype and Pro582Ser polymorphism of the hypoxia-inducible factor 1a (HIF-1A) gene in elite endurance athletes. .J. Appl. Physiol. 2010. 108 P.1497-1500. CrossRef PubMed
  22. Hagerman F.C. Applied physiology of rowing .Sports Med. 1984. 1(4). P.303. CrossRef PubMed
  24. Jung-whan Kim, Tchernyshyov I, Gregg L. Semenza, Chi V. Dang HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metabol. 2006 3, N 3. P.117-185. CrossRef PubMed
  26. Lee J-Won., Bae Seong Hui, Jeong Joo-Won. Hypoxia-inducible factor (HIF-1) a: its protein stability and biologi­cal functions .Exp. and Molec. Med. 2004. 36, N 1. P. 13-19. CrossRef PubMed
  28. Lundby C., Gassman M., Pilergaard H. Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions . Eur. J. Appl Physiol. 2006. 96 (4). P.363-369. CrossRef PubMed
  30. Milkiewicz M., Pugh C.W., Egginton S. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice . J. Physiol. 2004. 560, N 1. R.21-26. CrossRef PubMed PubMedCentral
  32. Mason S.D., Howlett R.A., Kim M.J., Olfert I.M., Hogan M.C., Mc. Nulty W., Hickey R.P., Wagner P.D., Ronald K.C. Loss of Skeletal Muscle HIF-1A results in altered exercise endurance . Plos Biol. 2004. 10, N 2. P.1540-1547. CrossRef PubMed PubMedCentral
  34. Mason S.D., Rundqvist H., Papandreou I., Duh R., Mc-Nulty W.J., Howlett R.A., Olfert I.M., Sundberg C.J., Denko N.C., Poellinger L., Johnson R.S. HIF-1 in endur­ance training: suppression of oxidative metabolism .Amer. J. Physiol. Regul. Integr. Comp. Physiol. 2007. 293. R.2059-2069. CrossRef PubMed
  36. Nava-Salazar S. Sanchez-Rodriguez E., Mendoza-Rodriguez A., Moran S., Romero-Arauz J., Cerbon M. Poly­morphisms in the hypoxia-inducible factor 1 alpha gene in Mexican patients with preeclampsia: A case-control study . BMC Res. Notes. 2011. 4. R . 68. CrossRef PubMed PubMedCentral
  38. Percy M., Mooney S., Frances Mc Mullin M . A common poly­morphism in the oxygendependent degradation (ODD) domain of hypoxia induciable factor 1b (HIF 1b) does not Impair Pro- 564 hydroxylation . Mol.Cancer. 2003. 2. R.13-19.
  40. Pisani D.F., Dechesne C.A. Skeletal muscle HIF-1alpha expression is dependent on muscle fber type . J. Gen. Physiol. 2005. 126. P.173-178. CrossRef PubMed PubMedCentral
  42. Prior S.J., Hagberg J.M., Phares D.A., Brown M.D., Fairfull L., Ferrell R.E., Roth S.M. Sequence variation in hypoxia-inducible factor 1a (HIF-1a): association with maximal oxygen consumption . Physiol Genomics. 2003. 15. R. 20-26. CrossRef PubMed
  44. Rundqvist H. Skeletal muscle HIF-1 and exercise. 2008. Thesis for doctoral degree. Karolinska intitutet, Stock­holm. 40 p.
  46. Semenza G.L. O2-regulated gene expression: transcrip-tional control of cardiorespiratory physiology by HIF_1 . J. Appl. Physiol. 2004. 96 (3). P.1173-1177. CrossRef PubMed
  48. Tanimoto K., Yoshiga K., Eguchi H. Hypoxia-inducible factor-1[alpha] polymorphisms associated with enhanced transactivation capacity, implying clinical signifcance . Carcinogenesis. 2003. 24, N 11. P.1779-1783. CrossRef PubMed
  50. Williams A., Folland J. Similarity of polygenic profles limits the potential for elite human physical performance . J Phisiol. 2008. 586, N 1. P.113-121. CrossRef PubMed PubMedCentral

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.