Warning: include(phj2-admin/kernel/config.php): failed to open stream: No such file or directory in /zstorage3/vhosts/fz.kiev.ua/httpdocs/index.php on line 45

Warning: include(): Failed opening 'phj2-admin/kernel/config.php' for inclusion (include_path='.:/usr/local/share/pear') in /zstorage3/vhosts/fz.kiev.ua/httpdocs/index.php on line 45

Warning: Cannot modify header information - headers already sent by (output started at /zstorage3/vhosts/fz.kiev.ua/httpdocs/index.php:45) in /zstorage3/vhosts/fz.kiev.ua/httpdocs/kernel/content.php on line 3

Warning: array_unique() expects parameter 1 to be array, null given in /zstorage3/vhosts/fz.kiev.ua/httpdocs/kernel/content.php on line 77

Warning: Invalid argument supplied for foreach() in /zstorage3/vhosts/fz.kiev.ua/httpdocs/kernel/content.php on line 86
Fiziologichnyi Zhurnal - <a id="lj1_ret_bk_to_jl0_href_id" href="?list0=14">Fiziol. Zh. 2012;</a> <a id="lj1_ret_bk_to_jl0_href_id" href="?list1=70">58(3):</a> 95-112
Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(3): 95-112


Poly(adp -ribose) polymerase (parp ): physiologicaland pathological roles

N.V. Makogon, I.M Alexeyeva

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ


Abstract

PARPs are a large family of 18 enzymes found in most eukaryotes. PARP-1, the most abundant isoform, is activated by DNA breaks and catalyzes the post-translational modifcation of proteins. It forms polymers of ADP-ribose and attaches them to acceptor proteins, including histones, DNA repair proteins, transcription factors. PARP-1 is a key enzyme involved in a maintenance of genomic stability. Excessive activation of the enzyme has been shown to contribute to tissue injury and infammatory disorders. PARP is a key mediator of cell death in oxidative stress, ischemia and DNA damage. It also promotes the activation of proinfammatory gene expression. Inhibition of PARP-1 provides signifcant protection in animal models of cardiovascular, autoimmune and infammatory diseases. PARP inhibitors have shown antitumor activity because they compromise ability of cancer cells to repair DNA. PARP-1 is a promising therapeutic target.

Keywords: ПАРП, стабильность генома, гибельклеток, воспаление, ингибиторы ПАРП.

References

  1. Дрель В.Р., Шиманський І.О., Сибірна Н.О., Великий М.М. Роль PARP та процесу полі-ADP-рибозилювання протеїнів у регулюванні клітинних функцій // Укр. біохім.журн. – 2011. – 83. – С.5–34.
  2. Дрель В.Р., Сибірна Н.О. Нефропротекторна дія виноградних вин у тварин із експериментальним цукровим діабетом // Біол. студії. – 2009. – 3. – С.59–68.
  3. Пискунова Т.С., Юрова М.Н., Забежинский М.А., Анисимов В.Н. Поли(АДФ-рибоза)- полимераза – связь с продолжительностью жизни и канцерогенезом // Успехи геронтологии. – 2007. – 20. – С.82–90.
  4. Шиманський І.О., Кучмеровська Т.М. Некоферментна функція вітаміну РР та його біологічно активних похідних: сучасний стан проблеми // Укр. біохім. журн. – 2007. – 79. – С.59–68.
  5. Alano C.C., Garnier P., Ying W., Higashi Y., Kauppinen T.M., Swanson R.A. NAD+ depletion is necessary end suffcient for poly (ADP-ribose) polymerase-1-mediated neuronal death // J.Neurosci. – 2010. – 30. – P.2967–2978.
  6. Altmeyer V., Hottiger MO. Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and infammation in aging // Aging. – 2009. – 1. – P.458–469.
  7. Ame J., Spenlehauer C., de Murcia G. The PARP superfamily// Bioassays. – 2004. – 26. – Р.882–893.
  8. Andreone T.L., O’Connor M., Denenberg A., Hake P.W., Zingarelli B. Poly(ADP-ribose) polymerase-1 regulates activation of AP-1 in murine fbroblasts//J.Immunol. – 2003. – 170. – P.2113–2120.
  9. 9. Bai P., Csaba H., Szabo E., Gyure L., Bakondi E., Brunyanszki A., Gergely S., Szabo C., Virag L. Poly(ADP-ribose) polymerase mediates infammation in a mouse model of contact hypersensitivity // J. Investig. Dermatol. – 2009. – 129. – P.234–238.
  10. 10. Berger N.A. Poly(ADP-ribose) in the cellular response to DNA damage // Radiat. Res. – 1985. – 101. – P.4–15.
  11. Besson V.C. Drug targets for traumatic brain injury from poly(ADP-ribose) polymerase pathway modulation // Brit. J. Pharmacol. – 2009. – 157. – P.696–704.
  12. Boujrad H., Gubkina O., Robert N., Krantic., Susin S.A. AIF-mediated programmed necrosis // Cell Cycle. – 2007. – 6. – P.2612– 2619.
  13. Boulares A.H., Zoltoski A.J., Sherif Z.A., Jolly P., Massaro D., Smulson M.E. Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung infammation in a murine model of asthma // Amer. J. Respir. Cell. Mol. Biol. – 2003. – 28. – P.322–329.
  14. Caldecott K.W., Aoufouchi S., Johnson P., Shall S. XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular ‘nick-sensor’ in vitro // Nucleic Acids Res. – 1996. – 24. – P.4387–4394.
  15. Carillo A., Monreal Y., Ramirez P. , Marin L., Parrilla P., Oliver F.J., Yelamos J. Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells // Ibid. – 2004. – 32. – P.757–766.
  16. Chen A. PARP inhibitors in cancer treatment // Chin. J. Cancer. – 2011. – 30. – P.463–471.
  17. Chiarugi A. Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation and ameliorate autoimmune encephalomyelitis in rats // Brit. J. Pharmacol. – 2002. – 137. – P.761–770.
  18. Cole K., Perez-Polo J. Poly (ADP – ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H2O2 injury // J. Neurochemistry. – 2002. – 82. – P. 19–29.
  19. 19. Cook B.D., Dynek J.N., Chang W., Shostak G., Smith S. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres // Mol. Cell. Biol. – 2002. – 22. – P.332–342.
  20. 20. Cover C., Fickert P., Knight T., Fuchsbichler., Farhood A., Trauner M., Jaeschke H. Pathophysiological role of poly (ADP – ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice // Toxicol. Sci. – 2005. – 84. – P.201–208.
  21. Cuzzocrea S., Zingarelli B., Gilad E., Hake P., Salzman A.L., Szabo C. Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local infammation // Eur. J. Pharmacol. – 1998. – 342. – P.67–76.
  22. d’Adda di Fagagna F., Hande M.P., Tong W.M., Lansdorp P.M., Wang Z.Q., Jackson S.P. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability // Nat. Genet. – 1999. – 23. – P.76–80.
  23. D’Amours D., Desnoyers S., D’Silva I., Poirier G. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions // Biochem. J. – 1999. – 342. – P.249–268.
  24. Dawson V. Inhibition of poly (adenosine diphosphate-ribose) polymerase (PARP) in experimental models of neurologic diseases: cell death prevention // Retina. – 2005. – 25. – P.S31–S32.
  25. de Murcia J.M., Niedergang C., Trucco C., Ricoul M., Dutrillaux B., Mark M., Oliver F.J., Masson M., Dierich A., LeMeur M., Walztinger C., Chambon P., de Murcia G. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells // Proc. Natl. Acad. Sci. USA. – 1997. – 94, 14. – P.7303–7307.
  26. Devalaraja-Narashimha K., Singaravelu K., Padanilam B.J. Poly(ADP-ribose) polymerase-mediated cell injury in acute renal failure // Pharmacol. Res. – 2005. – 52. – P.44–59.
  27. Eltze T., Boer R., Wagner T., Weinbrenner S., McDonald M., Thiemermann C., Burkle A., Klein T. Imidazoquinolinone, imidazopyridine and isoquinolindione derivatives as novel and potent inhibitors of the PARP: a comparison with standard inhibitors // Mol.Pharmacol. – 2008. – 74. – P.1587–1598.
  28. Farez M., Quintana F., Gandhi R. Izquierdo G., Lucas M., Weiner H.L. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinfammation in progressive EAE // Nat. Immunol. – 2009. – 10. – P.958–964.
  29. 29. Festjens N., Vanden Berghe T., Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: Signaling cascades, important mediators and concomitant immune response // Biochim et Biophys Acta. – 2006. – 1757. – P.1371–1387.
  30. 30. Formentini L., Macchiarulo A., Cipriani G. Camaioni E., Rapizzi E., Pellicciari R., Moroni F., Chiarugi A. Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure // J. Biol. Chem. – 2009. – 284. – P.17668–17676.
  31. Gonzalez-Rey E., Martinez-Romero R., O’Valle F., Aguilar-Quesada R., Conde C., Delgado M., Oliver F.J. Therapeutic effect of a poly(ADP-ribose) polymerase-1 inhibitor on experimental arthritis by downregulating infammation and Th1 response // PLoS ONE. – 2007. – 10. – P.e1071.
  32. Grube K, Burkle A. Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specifc life span //Proc. Natl. Acad. Sci. USA. – 1992. – 89. – P.11759–11763.
  33. Ha H.C., Snyder S.H. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by AT P depletion // PNAS. – 1999. – 96. – P.13978–13982.
  34. Ha H.C., Hester L.D., Snyder S.H. Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia // Proc. Natl. Acad. Sci. USA. – 2002. – 99. – P.3270–3275.
  35. Hans C.P., Zerfaoui M., Naura A.S., Troxclair D., Strong J.P., Matrougui K., Boulares A.H. Thieno[2,3-c] isoquinolin-5-one, a potent poly(ADP-ribose)polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-defcient mice: effects on infammatory markers and lipid content // J. Pharmacol. Exp. Therap. – 2009. – 329. – P.150–158.
  36. Harraz M., Dawson T., Dawson V. Advances in Neuronal Cell Death 2007 // Stroke. – 2008. – 39. – P.286–288.
  37. Hassa P.O., Hottiger M. The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in infammatory disorders // Cell. Molec. Life Sci. – 2002. – 59. – P.1534–1553.
  38. Hassa P.O., Haenni S.S., Elser M., Hottiger M.O. Nuclear ADP-ribosylation in mammalian cells: where are we today and where are we going? // Microbiol. Mol. Biol. Rev. – 2006. – 70. – P.789–829.
  39. 39. Hough C.J., Smulson M.E. Association of poly(adenosine diphosphate ribosylated) nucleosomes with transcriptio-nally active and inactive regions of chromatin// Bioche­mistry. – 1984. – 23. – P. 5016–5023.
  40. 40. Hsiao S.J., Poitras M.F., Cook B.D., Liu Y. , Smith S. Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping // Mol. Cell. Biol. – 2006. –26. – P.2044–2054.
  41. Huang Q., Shen H.-M. The dual role poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage // Autophagy. – 2009. – 5. – P.273–276.
  42. Huang Q., Wu Y.-T., Tan H.-L., Ong C-N., Shen H-M. A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress// Cell Death Differ. –2009. – 16. – P.264–277.
  43. Jijon H., Churchill T., Malfair D., Wessler A., Jewell L.D., Parsons H.G., Madsen K.L. Inhibitor of poly(ADP-ribose) polymerase attenuates infammation in a model of chronic colitis//AJP-Gastrointest. Liver Physiol. – 2000. – 279. – P.G641–G651.
  44. Jog N.R., Dinnall J.A., Gallucci S., Madiao M.P., Carricchio R. Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating infammation // J. Immunol. – 2009. – 182. – P. 7297–7306.
  45. Khandoga A., Enders G., Biberthaler P., Krombach F. Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury // AJP-Gastrointest. Liver Physiol. –2002. – 283. – P.G553–G560.
  46. Kirkland J. Poly ADP-ribose polymerase-1 and health// Exp. Biol. Med. – 2010. – 235. – P.561–568.
  47. Koh S.H., Park Y., Song C.W., Kim J.G., Kim K., Kim J., Kim M-H., Lee S.R., Kim D.W., Yu H-J., Chang D., Hwang S.J., Kim S.H. The effect of PARP inhibitor on ischaemic cell death, its related infammation and survival signals // Eur. J. Neurosci. – 2004. – 20. – P.1461–1472.
  48. Krishnakumar R., Kraus W.L. The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets // Mol. Cell. – 2010. – 39. – P.8–24.
  49. 49. Krysko D.V., D’Herde K., Vandenabeele P. Clearance of apoptotic and necrotic cells and its immunological consequences // Apoptosis. – 2006. – 11. – P.1709–1726.
  50. 50. Kuchmerovska T., Shymanskyy I., Donchenko G., Kuchmerovskyy M., Pakirbaeva L., Klimenko A. Poly(ADP-ribosyl)ation enhancement in brain cell nuclei is associated with diabetic neuropathy // J. Diabet. Comp. – 2004. – 18. – P.198–204.
  51. Lindahl T., Satoh M.S., Poirier G.G., Klungland A. Post–translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks // Trends. Biochem. Sci. – 1995. – 20. – P.405–411.
  52. Mabley J.G., Jagtap P. , Perretti M., Getting S., Salzman A., Virag L., Szabo E., Soriano F., Liaudet L., Abdelkarim G., Hasko G., Marton A., Southan G., Szabo C. Anti-inflammatory effects of a novel, potent inhibitor of poly(ADP-ribose)polymerase // Infam. Res. – 2001. – 50. – P. 561–569.
  53. Makogon N., Voznesenskaya T., Bryzgina T ., Sukhina V., Grushka N., Alexeyeva I. Poly(ADP-ribose) polymerase inhibitor, 3-aminobenzamide, protects against experimental immune ovarian failure in mice // Reprod. Biol. – 2010. – 10. – P. 215–226.
  54. Malanga M., Althaus F.R. The role of poly(ADP-ribose) in the DNA damage signaling network // Biochem. Cell. Biol. – 2005. – 83. – P.354–364.
  55. Meisterernst M., Stelzer G., Roeder R. Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro // Proc. Natl. Acad. Sci. USA. – 1997. – 94. – P.2261–2265.
  56. Menissier de Murcia J., Ricoul M., Tartier L., Niedergang C., Huber A., Dantzer F., Schreiber V. , Ame J.C., Dierich A., LeMeur M., Sabatier L., Chambon P., de Murcia G. Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse // EMBO J. – 2003. – 22. – P 2255–2263.
  57. Miyamoto T., Kakizawa T., Hashizume K. Inhibition of nuclear receptor signaling by poly(ADP-ribose) polymerase // Mol. Cell. Biol. – 1999. – 19. – P.2644–2649.
  58. Moroni F., Meli E., Peruginelli F., Chiarugi A., Cozzi A., Picca R., Romagnoli P., Pellicciari R., Pellegrini-Giampietro D. Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia // Cell Death Differ. – 2001. – 8. – P.921–932.
  59. 59. Morrow D.A., Brickman C.M., Murphy S.A., Baran K., Krakover R., Dauerman H., Kumar S., Slomowitz N., Grip L., McCabe C.H., Salzman A.L. A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial // J. Thromb. Thrombolysis. – 2009. – 27. – P. 359–364.
  60. 60. Мota R., Sanchez-Bueno F., Berenguer-Pina J., Hernandez– Espinosa D., Parilla P. , Yelamos J. Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. // Brit. J. Pharmacol. – 2007. – 151. – P.998–1005.
  61. Moubarak R.S., Yuste V.J., Artus C., Bouharrour A., Greer P.A., Menissier-de Murcia J., Susin S.A. Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis // Mol. Cell. Biol. – 2007. – 27. – P.4844–4862.
  62. Nakajima H., Nagaso H., Kakui N., Ishikawa M., Hiranuma T., Hoshiko S. Critical role of the automodifcation of poly(ADP-ribose)polymerase-1 in nuclear factor-kappa B-dependent gene expression in primary cultured mouse glial cells // J. Biol. Chem. – 2004. – 279. – P.42774–42786.
  63. Oh K.S., Lee S., Yi K.Y., Seo H.W., Koo H.N., Lee B.H. A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR–33889 [2[methoxycarbonyl (4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia // J. Pharmacol. Exp. Therap. – 2009. – 328. – P.10–18.
  64. Oliver F., Menissier-de Murcia J., Nacci C., Decker P., Andriantsitohaina R., Muller S., de la Rubia G., Stoclet J., de Murcia G. Resistance to endotoxic shock as a consequence of defective NF-kB activation in poly(ADP-ribose) polymerase-1 defcient mice//EMBO J. – 1999. – 18. – P.4446–4454.
  65. Oliver A.W., Ame J.C., Roe S. Good V., de Murcia G., Pearl L.H. Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2 // Nucleic Acids Res. – 2004. – 32. – P.456–464.
  66. Oumouna-Benachour K., Hans C., Suzuki Y., Naura A., Datta R., Belmadani S., Fallon K., Woods C., Boulares A. Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promote factors of plaque stability in ApoE-defcient mice // Circulation. – 2007. – 115. – P.2442–2450.
  67. O’Valle F., Del Moral R., Benitez M., Martin-Oliva D., Gomez-Morales M., Aguilar D., Aneiros-Fernandez J., Hernandez–Cortes P. , Osuna A., Moreso F., Seron D., Oliver F.J., Del Moral R.G. Poly(ADP-ribose) polymerase-1 expression is related to cold ischemia, acute tubular necrosis and delayed renal function in kidney transplantation // PLoS ONE. – 2009. – 4. – P.e7138–e7145.
  68. Pacher P., Szabo C. Role poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors // Cardiovasc. Drug Rev. – 2007. – 25. – P. 235–260.
  69. 69. Pacher P., Szabo C. Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease // Amer. J. Pathol. – 2008. – 173. – P.2–13.
  70. 70. Pagano A., Pitteloud C., Reverdin C., Metrailler-Ruchonnet I., Donati Y. , Barazzone Argiroffo C. Poly(ADP-ribose) polymerase activation mediates lung epithelial cell death in vitro but is not essential in hyperoxia-induced lung injury // Amer. J. Respir. Cell. Mol. Biol. – 2005. – 33. – P.555–564.
  71. Peralta–Leal A., Rodriguez-Vargas J.M., Aguilar-Quesada R., Rodriguez M.I., Linares J.L., de Almodovar M.R., Oliver F.J. PARP inhibitors: new partners in the therapy of cancer and infammatory diseases // Free Radic. Biol. Med. – 2009. – 47. – P. 13–26.
  72. Radovits T., Seres L., Gero D., Lin L.N., Beller C.J., Chen S.H., Zotkina J., Berger I., Groves J.T., Szabo C., Szabo G. The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction // Mech. Ageing Dev. – 2007. – 128. – P.173–181.
  73. Rajesh M., Mukhopadhyay P., Godlewski G., Batkai S,, Hasko G,, Liaudet L,, Pacher P. Poly(ADP-ribose) polymerase inhibition decreases angiogenesis // Biochem. and Biophys. Res. Commun. – 2006. – 350. – P.1056–1062.
  74. Rouleau M., Patel A., Hendzel M.J., Kaufmann S.H., Poirier G.G. PARP inhibition: PARP-1 and beyond // Nat. Rev. Cancer. – 2010. – 10. – P.293–301.
  75. Scaffdi P., Misteli T., Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers infammation // Nature. – 2002. – 418. – P. 191–195.
  76. Scott G.S., Kean R.B., Mikheeva T., Fabis M.J., Mabley J.G., Szabo C., Hooper D.C. The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation // J. Pharmacol. Exp. Therap. – 2004. – 310. – P.1053–1061.
  77. Simbulan-Rosenthal C.M., Ly D.H., Rosenthal D.S., Konopka G., Luo R., Wang Z.Q., Schultz P.G., Smulson M.E. Misregulation of gene expression in primary fbroblasts lacking poly(ADP-ribose) polymerase // Proc. Natl. Acad. Sci. USA. – 2000. – 97. – P.11274–11279.
  78. Smith S., Giriat I., Schmitt A., de Lange T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres // Science. – 1998. – 282. – P.1484–1487.
  79. 79. Soos J., Engelhardt J.I., Siklos L., Havas L,, Majtenyi K. The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease // Neuroreport. – 2004. – 15. – P.1715–1718.
  80. 80. Szabo C., Lim L., Cuzzocrea S., Getting S.J., Zingarelli B., Flower R.J., Salzman A.L., Peretti M. Inhibition of poly(ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-infammatory effects // J. Exp. Med. – 1997. – 186. – P.1041–1049.
  81. Szabo C. Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications // Pharmacol. Res. – 2005. – 52. – P. 60–71.
  82. Szijarto A., Batmunkh E., Hahn O., Mihaly Z., Kreiss A., Kiss A., Lotz G., Schaff Z., Vali L., Blazovics A., Gero D., Szabo C., Kupcsulik P. Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status // J. Surg. Res. – 2007. – 142. – P.72–80.
  83. Toth-Zsamboki E., Horvath E., Vargova K., Pankotai E., Murthy K., Zsengeller Z., Barany T., Pek T., Fekete K., Kiss R., Preda I., Lacza Z., Gero D., Szabo C. Activation of PARP by myocardial ischemia and coronary reperfusion in human circulating leukocytes // Mol. Med. – 2006. – 12. – P.221–228.
  84. Troyano A., Sancho P., Fernandez C., de Blas E., Bernardi P. , Aller P. The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells // Cell. Death Differ. – 2003. – 10. – P.889–898.
  85. Veres B., Radnai B., Gallyas F., Varbiro G., Berente Z., Osz E., Sumegi B. Regulation of kinase cascades and transcription factors by a PARP inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced infammation in mice // J. Pharmacol. Exp. Therap. – 2004. – 310. – P. 247–255.
  86. Virag L., Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors // Pharmacol. Rev. – 2002. – 54. – P.375–429.
  87. Virag L. Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies // Current Vascular Pharmacol. – 2005. – 3. – P. 209–214.
  88. Wang X., Ohnishi K., Takahashi A., Ohnishi T. Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation // Oncogene. – 1998. – 17. – Р.2819–2825.
  89. 89. Wang Y., Dawson V.L., Dawson T.H. Poly(ADP-ribose) signals to mitochondrial AIF: a key event in Parthanatos // Exp. Neurol. – 2009. – 218. – P.193–202.
  90. 90. Weseler A.R., Geraets L., Moonen H.J., Manders R.J., van Loon L.J., Pennings H.J., Wouters E.F., Bast A., Hageman G.J. Poly(ADP-ribose) polymerase-1-inhibiting favonoids attenuate cytokine release in blood from male patients with chronic obstructive pulmonary disease or type 2 diabetes // J. Nutr. – 2009. – 139. – P.952–957.
  91. 91. Xu Y., Kim S.O., Li Y., Han J. Autophagy contributes to caspase-independent macrophage cell death // J. Biol. Chem. – 2006. – 281. – Р. 19179–19187.
  92. 92. Yu S.W., Wang H., Poitras M.F., Coombs C., Bowers W.J., Federoff H.J., Poirier G.G., Dawson T.M., Dawson V.L. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor // Science. – 2002. – 297. – P.259–263.
  93. 93. Yuan M., Siegel C., Zeng Z., Li J., Liu F., McCullough L. Sex differences in the response to activation of poly(ADP-ribose) polymerase after experimental stroke //Exp.Neurol. – 2009. – 217. – P.210–218.
  94. 94. Zingarelli B., Hake P.W., O’Connor M., Denenberg A., Wong H.R., Kong S., Aronow B.J. Differential regulation of AP-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1 // Amer. J. Physiol. Heart Circ. Physiol. – 2004. – 286. – P.H1408–1415.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.