Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(3): 85-94


Evaluation of biological effects and possiblemechanisms of action of static magnetic field

V.F. Chekhun, D.V. Demash, L.A. Naleskina

    R.E. Kavetsky institute of experimental pathology,oncology and radiobiology, NAS of Ukraine, Kyiv.


Abstract

Modern views on mechanisms of interaction between static magnetic feld and cells or cellular structures are reviewed. An analysis of the data about possible biotropic effects of this factor was performed. The emphasis was put on the analysis of the studies in which moderate (0.1–1 T) static magnetic felds were used, because such felds are used for targeted delivery of magnetosensitive nanocomposites in development of new strategies in target therapy of patients with malignant neoplasms. Based on available data it was concluded that the primary cause of changes in cells after incubation in external static magnetic feld is disruption of free radical metabolism and elevation of their concentration. Such disruption causes oxidative stress, and, as a result, damages ion channels, leading to changes in cell morphology and expression of different genes and proteins, and also changes in apoptosis and proliferation.

Keywords: постоянное магнитное поле, свободно-радикальные процессы, кальций, ионные каналы.

References

  1. Березов Т.Т., Яглова Н.В., Дмитриева Т.Б., Чехонин В.П., Жирков Ю.А. Направленный транспорт лекар­ственных средств с помощью липосом // Вестн. Рос. акад. мед наук. – 2004. – 3. – C. 42–46.
  2. Бинги В.Н., Савин А.В. Физические проблемы действия слабых магнитных полей на биологические системы // Успехи. физ. наук. – 2003. – 173. – C. 265–300.
  3. Вайнер Л.М., Подоплелов А.В., Лешина Т.В. Влияние магнитного поля на скорость разложения H2O2 ката-лазой и комплексом ЭДТА с Fe3+ // Биофизика. – 1978. – 23, №2. – C. 234–241.
  4. Гуляр С.А., Лиманский Ю.П. Постоянные магнитные поля и их применение в медицине. – К.: Ин-т физиоло­гии им. А.А. Богомольца НАН Украины, 2005. – 320 с.
  5. Хёрд К.М. Многообразие видов магнитного упорядочивания в твердых телах // УФН. – 1984. - 142, №2. – C. 331-357.
  6. Чехун В.Ф., Горобець С.В., Горобець О.Ю. Магніто-впорядковані сполуки ендогенного заліза і проблема впливу постійних магнітних полів на біосистеми // Біофізич. вісн. – 2010. – 29, №2. – С. 123–130.
  7. Чехун В.Ф., Шишова Ю.В. Современные взгляды на механизмы формирования лекарственной устойчи­вости опухолей // Онкология. – 2000. – 2, №1-2. – С. 11-15.
  8. Шпак А.П., Горбик П.П., Чехун В.Ф. Нанокомпозиты медико-биологического назначения на основе уль­традисперсного магнетита. – В кн.: Физико-химия нанокомпозитов и супрамолекулярных структур: Сб. тр. / Под ред. А.П. Шпака, П.П. Горбика. – К.: Наук. думка, 2007. – C. 45–87.
  9. 9. Andresen T. L., Jensen S. S., Jorgensen K. Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specifc drug release // Prog. Lipid Res. – 2005. – 44. – P. 68–97.
  10. 10. Aoki H., Yamazaki H., Yohino T. Akagi T. Effects of static magnetic felds on membrane permeability of a cultured cell line // Res. Commun. Chem. Pathol. Pharmacol. – 1990. – 69, №1. – P. 103–106.
  11. Arosio P., Levi S. Ferritin, iron homeostasis, and oxidative damage // Free Radic. Biol. Med. – 2002. – 33. – P. 457–463.
  12. Ayrapetyan S.N., Grigirian K.V., Avanesian A.S., Stambolstian K.V. Magnetic fields alter electrical properties of solutions and their physiological effects // Bioelectromagnetics. – 1994. – 15, № 2. – P. 133–142.
  13. Azanza M.J., Del Moral A. Cell membrane biochemistry and neurobiological approach to biomagnetism // Prog. Neurobiol. – 1994. – 44, №6. – P. 517–601.
  14. Berridge M.J. Unlocking the secrets of cell signaling // Annu. Rev. Physiol. – 2005. – 67. – P. 1–21.
  15. Beu T.A. Simulations of Biological Ion Channels in Intense Magnetic Fields // Physica. – 2004. – 49. – P. 91–97.
  16. Blumenthal N.C., Ricci J., Breger L., Zychlinsky A., Solomon H., Chen G.G., Kuznetsov D., Dorfman R. Effects of low-intensity AC and/or DC electromagnetic felds on cell attachment and induction of apoptosis // Bioelectromagnetics. – 1997. - 18, №3. – P. 264–272.
  17. Carson J.J., Prato F.S., Drost D.J. Diesbourg L.D, Dixon S.J. Time-varying magnetic felds increase cytosolic free Ca2+ in HL-60 cells // Amer. J. Physiol. – 1990. – 259. – P. 687–692.
  18. Dobson J. Magnetic nanoparticles for drug delivery // Drug Develop. Res. – 2006. –67, № 1. – P. 55–60.
  19. 19. Eveson R.W., Timmel C.R., Brocklehurst B. Hore P.J., McLauchlan K.A. The effects of weak magnetic felds on radical recombination reactions in micelles // Int. J. Radiat. Biol. – 2000. – 76, №11. – P.1509–1522.
  20. 20. Fanelli C., Coppola S., Barone R. Colussi C., Gualandi G., Volpe P., Ghibelli L. Magnetic felds increase cell survival by inhibiting apoptosis via modulation of Ca2+ infux // FASEB J. – 1999. – 13, №1. – P. 95–102.
  21. Fenske D.B. Cullis P.R. Liposomal nanomedicinas // Exp. Opin Drug Deliv. – 2008. – 5, №5. – P. 25–44.
  22. Feynman R.P., Leighton R., Sands M. The Feynman lectures on physics, USA: Addison-Wesley. – Vol. 2. – 1963. – Ch. 37.
  23. Forcada A., Suarez I., Fernandez B. Acute and chronic effects of exposure to a 1-mT magnetic feld on the cytoskeleton, stress proteins, and proliferation of astroglial cells in culture // Environmental. Res. – 2005. – 98, №3. – P. 355–362.
  24. Fortin-Ripoche J.-P., Martina M.S., Gazeau F., Menager C., Wil helm C., Bacri J.C., Lesieur S., Clement O. Magnetic Targeting of Magnetoliposomes to Solid Tumors with MR Imaging Monitoring in Mice: Feasibility // Radiology. – 2006. – 239, №2. – P. 415–424.
  25. Funk R.H., Monsees T., Ozkucur N. Electromagnetic effects – From cell biology to medicine // Prog. Histochem. and Cytochem.- 2009. – 43, №4. – P. 177–264.
  26. Grundler W., Kaiser F., Keilmann F., Walleczek J. Mechanisms of electromagnetic interaction with cellular systems // Naturwissenschaften - 1992. – 79. – P. 5551–5597.
  27. Guiasola C., Desco M., Millan O., Villanueva F.J., Garcia-Barreno P. Biological dosimetry of magnetic resonance imaging // J. Magn. Reson. Imaging. – 2002. – 15, №5. – P. 584–590.
  28. Hafeli U. Magnetically modulated therapeutic systems // Int. J. Pharmacol. – 2004. – 277, №1-2. – P. 19–24.
  29. 29. Higashi T., Yamagishi A., Takeuchi A., Kawaguchi N., Sagawa S., Onishi S., Date M. Orientation of erythrocytes in a strong static magnetic feld // Blood. – 1993. - 82. – P.1328–1333.
  30. 30. Hirai T., Nakamichi N., Yoneda Y. Activator protein-1 complex expressed by magnetism in cultured rat hippocampal neurons // Biochem. and Biophys. Res. Commun. – 2002. – 292, №1. – P. 200–207.
  31. Hiraoka M., Miyakoshi J., Li Y.P., Shung B. Takebe H., Abe M. Induction of c-fos gene expression by exposure to a static magnetic feld in HeLaS3 cells // Cancer Res. – 1992. – 52, № 23. – P. 6522–6524.
  32. Hirose H., Nakahara T., Zhang Q.M., Yonei S., Miyakoshi J. Static magnetic feld with a strong magnetic feld gradient (41.7 T/m) induces c-Jun expression in HL-60 cells // In Vitro Cell Dev. Biol. Anim. – 2003. – 39, № 8–9. – P. 348–352.
  33. ICNIRP. Exposure to static and low frequency electromagnetic fields. – In: Biological effects and health consequences (0–100 kHz) // Matthes R., McKinlay A.F., Bernhardt J.H., Vecchia P., Veyret B. (Eds.). – Munchen, Markl-Druck, 2003.
  34. Iino M., Okuda Y. Osmolality dependence of erythrocyte sedimentation and aggregation in a strong magnetic feld // Bioelectromagnetics. – 2001. – 22, №1. – P. 46–52.
  35. Ikehata M., Koana T., Suzuki Y., Shimizu H., Nakagawa M. Mutagenicity and co-mutagenicity of static magnetic felds detected by bacterial mutation assay // Mutat. Res. – 1999. – 427. – P. 147–150.
  36. Kittel C. Introduction to solid state physics. – New York: Wiley, 1996. – 689 p.
  37. Kotani H., Kawaguchi H., Shimoaka T. Iwasaka M., Ueno S., Ozawa H., Nakamura K., Hoshi K. Strong static magnetic feld stimulates bone formation to a defnite orientation in vitro and in vivo // J. Bone. Miner. Res. – 2002. – 17, №10. – P. 1814–1821
  38. Kovacs-Balint Z., Csatho A., Laszlo J.F., Juhasz P., Hernadi I. Exposure to an inhomogeneous static magnetic feld increases thermal pain threshold in healthy human volunteers // Bioelectromagnetics. – 2011. – 32, №2. – P. 131–139.
  39. 39. Le Chapellier P., Matta B. Cellular perception and static magnetic felds active penetration depth for pain magnetotherapy // PIERS Online. – 2010. – 6, №3. – P. 287-292.
  40. 40. Lin S.L., Chang W.J., Chiu K.H., Hsieh S.C., Lee S.Y., Lin C.T., Chen C.C., Huang H.M. Mechanobiology of MG63 osteoblast-like cells adaptation to static magnetic forces // Electromagn. Biol. Med. – 2008. – 27, №1. – P. 55–64.
  41. McCann J., Dietrich F., Rafferty C., Martin A. A critical review of the genotoxic potential of electric and magnetic felds // Mutat. Res. – 1993. – 297. – P. 61–95.
  42. Minelli C., Lowe S. B., Stevens M.M. Engineering nanocomposite materials for cancer therapy // Small. – 2010. – 6. – P. 2336–2357.
  43. Miyakoshi J. The review of cellular effects of a static magnetic feld // Sci. and Technol. Advan. Mat. – 2006. – 7, № 4. – P. 305–307.
  44. Miyamoto H., Yaaguchi H., Ikehara T. Kinouchi Y. Effects of electromagnetic felds on K+ (Rb+) uptake by HeLa cells. – In: Biological effects of magnetic and electromagnetic felds (ed. Ueno S.). New York: Plenum press, 1996. – P. 101–119.
  45. Mohtat N., Cozens F.L., Hancock-Chen T., Scaiano J.C., McLean J., Kim J. Magnetic feld effects on the behavior of radicals in protein and DNA environments // Photochem. Photobiol. – 1998. – 67, №1. – P. 111–118.
  46. Morris C.E., Skalak T.C. Chronic static magnetic feld exposure alters microvessel enlargement resulting from surgical intervention // J. Appl. Physiol. – 2007. – 103. – P. 629–636.
  47. Nossol B., Buse G., Silny J. Infuence of weak static and 50 Hz magnetic felds on the redox activity of cytochrome-C oxidase // Bioelectromagnetics. – 1993 – 14, № 4. – P. 361–372.
  48. Nygren P. , Larsson R. Overview of the clinical effcacy of investigational anticancer drugs // J. Int. Med. – 2003. – 53, №2. – P. 46–75.
  49. 49. Okano H. Effects of static magnetic felds in biology: role of free radicals // Front Biosci. – 2008. – 13. – P. 6106–6125.
  50. 50. Okazaki M., Seiyama A., Kon K., Maeda N., Shiga T. Boycott effect with vertical cylinder for paramagnetic red blood cells under the inhomogenous magnetic feld // J. Coll. Interface Sci. – 1991. – 146, №2. – P. 590–593.
  51. Pacini S., Aterini S., Pacini P., Ruggerio C., Gulisano M., Ruggerio M. Infuence of static magnetic feld on the antiproliferative effects of vitamin D on human breast cancer cells // Oncol. Res. – 1999. – 11, №6. – P.265–271.
  52. Pacini S., Vannelli G.B., Barni T., Ruggerio M., Sardi I., Pacini P., Gulisano M. Effect of 0.2 T static magnetic feld on human neurons: remodeling and inhibition of signal transduction without genome instability // Neurosci. Lett. – 1999. – 267, №3. – P.185–188.
  53. Papatheofanis F.J. Papatheofanis B.J. Short-term effect of exposure to intense magnetic felds on hematologic indices of bone metabolism // Invest. Radiol. – 1989. – 24, №3. – P. 221–223.
  54. Park J.W. Liposome-based drug delivery in breast cancer treatment // Breast Cancer Res. – 2002. – 4. – P. 95–99.
  55. Polyak B., Friedman G. Magnetic targeting for site-specifc drug delivery: applications and clinical potential // Exp. Opinion on Drug Delivery. – 2009. – 6, №1. – P. 53–70.
  56. Raguz S, Yague E. Resistance to chemotherapy: new treatments and novel insights into an old problem // Br. J. Cancer – 2008. - 99. – P. 387–391.
  57. Ritz T., Thalau P. , Phillips J.B., Wiltschko R., Wiltschko W. Resonance effects indicate a radical-pair mechanism for avian magnetic compass // Nature. – 2004. – 429. – P. 177–180.
  58. Rosen A.D. Mechanism of action of moderate-intensity static magnetic fields on biological systems // Cell Biochem. Biophys. – 2003. – 39, №2. – P. 163–173.
  59. 59. Rosen A.D. Studies on the Effect of Static Magnetic Fields on Biological Systems // PIERS Online. – 2010. – 6, №2. – P. 133–136.
  60. 60. Ruggiero M. Static magnetic felds, blood and genes. An intriguing relationship // Cancer Biol. & Therapy. – 2008. – 7, №4. – P. 1–2.
  61. Saunders R. Effects of static magnetic felds relevant to human health // Progr. in Biophys. and Molec. Biol. – 2005. – 87, №2–3. – P. 225–239.
  62. Sonnier H. Kolomytkin O., Marino A. Action potentials from human neuroblastoma cells in magnetic felds // Neurosci. Lett. – 2003. – 337, №3. – P. 163–166.
  63. Suzuki Y. , Ikehata M., Nakamura K., Nishioka M., Asanuma K., Koana T., Shimizu H. Induction of micronuclei in mice exposed to static magnetic felds // Mutagenesis. – 2001. – 16, №6. – P. 499–501.
  64. Teodori L., Grabarek J., Smolewski P. Ghibelli. L., Bergamaschi A., de Nicola M., Darzynkewicz Z. Exposure of cells to static magnetic feld accelerates loss of integrity of plasma membrane during apoptosis // Cytometry. 2002. – 49, № 3. – P. 113–118.
  65. Tofani S., Barone D., Cintorino M., de Santi M.M., Ferrara A., Orlassino R., Ossola P., Peroglio F., Rolfo K., Ronchetto F. Static and ELF magnetic felds induce tumor growth inhibition and apoptosis. – Bioelectromagnetics. – 2001. – 22, №6. – P. 419–428.
  66. Torbet J., Ronziere M.-C. Magnetic alignment of collagen during self-assembly // Biochem. J. – 1984. – 219. – P. 1057–1060.
  67. WHO, Environmental Health Criteria 232. Static Fields. – WHO, 2006. – 369 p.
  68. Xu C., Fan Z., Chao Y.-L., Du L., Zhang F.Q. Magnetic fields of 10mT and 120mT change cell shape and structure of F-actins of periodontal ligament cells // Bioelectrochemistry. – 2008. – 72, №1. – P. 41–46.
  69. 69. Yang J., Lee J., Kang J, Oh S.J., Ko H.-J., Son J.-H., Lee K., Suh J.S., Huh J.M. Smart Drug-Loaded Polymer Gold Nanoshells for Systemic and Localized Therapy of Human Epithelial Cancer // Advanc. Mater. – 2009. – 21, № 43. – P. 4339–4342.
  70. 70. Zhang Q.M., Tokiwa M., Doi T., Nakahara T., Chang P.W., Nakamura N., Hori M., Miyakoshi J., Yonei S. Strong static magnetic feld and the induction of mutations through elevated production of reactive oxygen species in Escherichia coli soxR // Int. J. Radiat. Biol. – 2003. – 79. – P.281–286.
  71. Zmyslony M., Palus J., Jajte J., Dziubaltowska E.Rajkowska E. DNA damage in rat lymphocytes treated in vitro with iron cations and exposed to 7 mT magnetic felds (static or 50 Hz) // Mutat. Res. – 2000. – 453. – P. 89–96.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.