Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(3): 77-84

Effects of intermittent normobaric hypoxia on the state of the CNS and cerebral circulation in children with cerebral palsy.

Yatsenko KV, Berezovskii VA, Deyeva JV.

    O.O.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz58.03.077


Abstract

We studied the effects of intermittent normobaric hypoxia (INH) on the processes of CNS functions and cerebral circulation recovery in children with cerebral palsy (CP). Altogether, 87 patients (from 8.5 months to 12 years) with CP were examined and received the course of treatment. Clinico-neurophysiological ex­amination was performed before the treatment and immediately after termination of the therapeutic course. Patients were divided into two groups; age and sex distributions and clinical manifestations of CP were randomized. The comparison group was formed from 34 children who received the course of the generally ac­cepted complex therapy (medicamental treatment, massage, Bobat-therapy, Vojta-therapy at al).. The main group included 53 patients who, in addition to the same therapy, were exposed to INH using an individual apparatus for artifcial mountain air, Borey-M, made in the Scientifc Medico-Engineering Center NORT (Ukrainian National Academy of Sciences, Kyiv). Children of the main group were exposed to the dosed normobaric sanogenetic level hypoxia intermittently once per day. For this purpose, we used a normobaric gas hypoxic mixture (12% O2 + 88% N2). Each cycle included a 15-min-long episode of breathing with the gas mixture alternated by a 5-min-long episode of breathing an ambient atmospheric air. The number of hypoxic cycles was gradually increased (from one to three). The entire course of treatment included, on average, 10 sessions. After complex therapy the stable positive effects on the motor status were observed in 94% of patients of the main group (exposed to INH) and in 74% of patients of the comparison group (unexposed to INH). EEG examination showed that positive dynamics of spectral EEG components were in 70% of patients of the main group and in 56% of children of the comparison group. Doppler examination showed that brain hemodynamics was normalized in 85% of patients of the main group and in 59% of children of the comparison group. In the course of ophthalmoscopic examination, we found that the dynamics of indices of the state of the eye fundus were expressed more clearly in children of the main group than in patients of the comparison group (in 32 and 12% of patients, respectively).

Keywords: дитячий церебральний параліч, перерив-часта нормобарична гіпоксія, адаптація.

Full text: (PDF, in English)

References

  1. Agadzhanyan AN, Mirrakhimov MM Mountains and body resistance. Moscow: Science, 1970. 182 p.
    2.  
  2. Berezovsky VA Allopathic and homeopathic principles in the treatment of diseases associated with oxygen starvation . Molecular aspects of adaptation to hypoxia. K .: Publishing House of Sciences. Opinion, 1979 P. 224-231.
    3.  
  3. Berezovsky VA, Deynega VG Physiological mechanisms of sanogenic effects of mountain climate. Ibid., 1988 224 p.
    4.  
  4. Zhirmunska EA The system of description and classification of human encephalograms. M. Medicine, 1984. 234 p.
    5.  
  5. Zayko MN, Beats YV, Butenko GM Pathophysiology: A Textbook. K .: Medicine, 2008. 703 p.
    6.  
  6. Zenkov LR, Karlov VA, Ronin MA Spectral analysis of EEG in children and adolescents with epilepsy: general characteristics and pathophysiological interpretation of the data . Journal. neurology and psychiatry. 1989. 89, No. 1. P. 15-19.
    7.  
  7. Kravchuk VE, Martyniuk VY, Zinchenko SM Doppler pulmonography in children . Fundamentals of medico-social rehabilitation of children with organic lesions of the nervous system. K .: Intermed, 2005. P. 140-146.
    8.  
  8. Lobov MA Correction of muscle tone and dysarthria in pediatric cerebral palsy . Journal. honey. Consilium medicum. 2001. 3, N 14. pp. 34-38.
    9.  
  9. Semenova KA Methodical recommendations for the use of working classification of cerebral palsy. M., 1973. 20 p.
    10.  
  10. Berezovsky V.Ya., Gorban EM, Levashov MI, Sutko-vyi AD Methodical recommendations of the Ministry of Health of Ukraine: Technology of increasing resistance of an organism with the help of hypoxytherapy. K., 2000. 34 p.
    11.  
  11. Berezovsky V.Ya., Yatsenko K.V. Guidelines of the Ministry of Health of Ukraine: Instrumental Orotherapy in Complex Rehabilitation of Children with Organic Nervous System Damage. K., 2009. 23 p.
    12.  
  12. Mikhailenko V.E. Clinico-neurophysiological justification for the use of physical factors in the rehabilitation of children with cerebral palsy: author. diss. of assignment degrees of Cand. honey. Sciences: Special. 03. 14. 04 Pathological Physiology. Yalta. 2005. 23 p.
    13.  
  13. Nadonenko OM, Martyniuk V.Yu., Zinchenko SM Electroencephalographic characteristics in children from birth to 3 years in the state of sleep and wakefulness . Fundamentals of medico-social rehabilitation of children with organic lesions of the nervous system. K .: Intermed, 2005. P. 120-134.
    14.  
  14. Panasyuk LO, Martyniuk VY, Zinchenko SM. Neurological status examination in newborns . Fundamentals of medico-social rehabilitation of children with organic nervous system lesions. There. pp. 47-53.
    15.  
  15. Rosin Yu. A. Dopplerography of cerebral vessels in children. St. Petersburg honey. Publishing House, 2004. 110 p.
    16.  
  16. Sidorenko EI Ophthalmology. M .: GEOTAR-MED, 2002. 408 p.
    17.  
  17. Sirotinin MM Life at heights and altitude sickness. K .: Publishing House of the USSR Academy of Sciences, 1939. 225 p.
    18.  
  18. Statistical Bulletin: Health Care Institutions and Morbidity of the Ukrainian Population in 2007 . State Statistics Committee of Ukraine. K., 2008. 96 p.
    19.  
  19. Osaulenko OG Statistical Yearbook of Ukraine: 2006 . State Statistics Committee of Ukraine. K .: Consultant, 2007. 575 p.
    20.  
  20. Palisano R., Rosenbaum P., Bartlett D., Livingston M. Content validity of the Expanded and Revised Gross Motor Function Classifcation System . Developmental Medicine and Child Neurology. 2007. N 9. P. 57-68.
    21.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.