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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(3): 72-76

Kidney function in oncologic patients after cisplastin chemotherapy

Hozhenko AI, Moskalenko OM, Sirman VM, ZhiZhnievs'ka OO, Storozhenko SA.

  1. DP Ukrainian scientific Institute of Medicine of Transport,Odesa, Ukraine
  2. The Center of transplantation of organs, tissues and cells,Ministry of Public Health of Ukraine, Kyiv, Ukraine
  3. Odesa Region Oncological Center, Ukraine


During examination of kidney function under cisplastin chemotherapy in oncologic patients the nephrotoxicity of the drug have been shown during 24 hours after administration. We found that in 24 hours after injection of cisplastin in the dose 50 mg/m2 of the surface of the body, the excretion of creatinine, sodium, potassium, osmotic active compounds and chlorides is increased more than two times, indicating for disorder in osmolality, volume and ionic regulation of kidney function. The determined peculiarities are consequences of kidney injuries, which are confrmed by an increase in erythrocyte-and leucocyteuria. We showed that alterations in homeostatic kidney function is due to damage of renal tubules. Our study necessitates a need for renal protection during the whole period of cisplastin chemotherapy.

Keywords: cisplatin, nephrotoxicity, kidney function, renalprotection.


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