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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(3): 27-31

Immune response in mice following intrabrain injections of allogeneic spleen or brain cells

Lisianyĭ MI, Kliuchnykova AI.

    A.P. Romodanov Institute of Neurosurgery NAMN of Ukraine, Kyiv, Ukraine


Cytotoxical activity of spleen lymphocytes and lymphatic knots was studied. Accumulation of anibodies in blood serum of recipient in response to intrabrain injection of the antigen was investigated. Cellular and humoral immune response of mice developed with the intrabrain injection of alohenic cells. The data obtained suggest that there is no isolation of the brain, because antigen injection to the brain is able to induce the immune reaction.

Keywords: the immune answere in a brain, a brain, allogenic cells, intrabrain immunization.


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