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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(3): 27-31


Immune answer of mice’s in case of intrabrain injection of thealohenic spleen cells or brain

M.I. Lisyany, A.I. Kluchnikova

    A.P. Romodanov Institute of Neurosurgery NAMN of Ukraine, Kyiv.


Abstract

Cytotoxical activity of spleen lymphocytes and lymphatic knots was studied. Accumulation of anibodies in blood serum of recipient in response to intrabrain injection of the antigen was investigated. Cellular and humoral immune response of mice developed with the intrabrain injection of alohenic cells. The data obtained suggest that there is no isolation of the brain, because antigen injection to the brain is able to induce the immune reaction.

Keywords: the immune answere in a brain, a brain, allogenic cells, intrabrain immunization.

References

  1. Кузовкова Н.А. Оценка активности естественных киллеров колориметрическим методом // Иммунология. – 1991. – №4. – С. 59–61.
  2. Лисяный Н.И., Любич Л.Д. Особенности развития иммунных реакций при нейротрансплантации клеток фетального мозга // Нейроиммунология. – 2009. – 7, № 3–4, – С. 4–14.
  3. Морозов С.Г., Магаева С.В., Грибова И.Е. Иммунологический надзор в ЦНС // Там же. – 2005. – 3, № 3–4. – С. 5–9.
  4. Чернушенко Е.Ф., Когосова Л.С. Микроцитотоксический метод // Иммунол. методы исследования в клинике. – 1998. – 410 с.
  5. Cserr H.F., Knopf P.M. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain : A new view // Immunol. Today. – 1992. – 13. – P. 507–512.
  6. Drukker M., Katz G., Urbach A. Characterization of the expressjn of MHC proteins in human embryonic stem cells // PNAS USA. – 2002. – 99, № 15. – P. 9864–9869.
  7. Harling-Berg C.J. Role of cervical lymphatics in the T2-type hierarchy of CNS immune regulation // J. Neuroimmnol. – 1999. – 101. – P. 111–127.
  8. Huang F.P., Plantt N., Wykes M. Discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes // J. Exp. Med. – 2000. – 191. – P. 435–444.
  9. 9. Jonston M. Сеrеbrospinal fuid transport : а lуmрhаtic реrspective // Сеrеbrospin. Fluid Res. –2004. – 2. – P. 1–12.
  10. 10. Nagata K., Tanaka K., Ogawa K. Selective ecspression of a novel surface molecule by human Тh2 cells in vivo // J. Immunol. – 1999. – 162. – P. 1278–1286.
  11. Neumann Н., Wеkег1е Н. Neuronal control of the immune response in the central nervous system:linking brain immunity to neurodegeneration // J. Neuropathol. Exp. Neurol. — 1998. —57, № 1. – P. 1–9.
  12. Papaiconomou C., Zakharov A, Azizi N. Reassessment of the pathways responsible for cerebrospinal fuid absorption in the neonate // Child. Nerv. Syst. – 2004. – 20. – P. 29–36.
  13. Schmitt A.B., Brook G.A., Buss A. Dynamics of microglial activation in the spinal cord after cerebral infarction are reveled by expression of MHC class ІІ antigen // Neuropathol. Appl. Neurobiol. – 1998. –24, № 3. – P. 167–176.

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