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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(2): 59-65

The influence of long-term monosodium glutamate feeding on the structure of rats pancreas

Leshchenko IV, Shevchuk VH, Falalieieva TM, Beregova TV.

    O.O. Bogomolets National Medical University, Kyiv;Taras Shevchenko National University of Kyiv, Ukraine


The influence of prolonged administration of monosodium glutamate (MSG) on pancreas in rats was studied. It was established that 30-days feeding by MSG in the doses 15 to 30 mg/kg (equivalent to 1 and 2 g/person) leads to necrotic, necrobiotic and degenerative changes in exocrine and endocrine cells, leukocytic and lymphoid infiltration, perivascular and interstitial fibrosis, edema and discirculatory disorders. Introduction of sodium glutamate increases the cross-sectional area of nuclei of exocrine and endocrine cells, indicating inten­sification of synthetic processes in the cells of the pancreas and reduces the cross-sectional area of exocrine pancreatic cells, which is a sign of stimulation of secretory processes in exocrine cells. The changes described are characteristic of the acute pancreatitis. It is concluded that the maximum daily dose of food supplements containing glutamic acid and its salts should be reviewed because of their adverse effects on the pancreas. It is concluded that the maximum dose of MSG should be reconsidered taking into account its influence on the pancreas.

Keywords: мonosodium glutamate, pancreas, pancreatitis.


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