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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2012; 58(2): 44-50


The influence of autologous umbilical cord blood and donor blood on cytokine profile of newborns with transposition of great vessels

Tkachenko IaV, Vorobĭova HM, Zhovnir VA, Iemets' IM.

    State University «Scientific-Pract. Medical Center of Pediatric Cardiology and Cardiac Surgery of the Ministry of Health of Ukraine », Ukraine
DOI: https://doi.org/10.15407/fz58.02.044

Abstract

We investigated the serum levels of proinflammatory and anti-inflammatory cytokines (TNF-a, IL-1b, IL-6, IL-8, IL-10) in newborns with transposition of the great arteries to whom during the defect correction the autologous umbilical cord blood and blood components were administered before the surgery and at the 1st, 3rd, 7th day after the surgery. We found that in the group of newborns to whom during the operation the blood components were used, the levels of pro-inflammatory interleukins were high before surgery and at the 1st, 3rd and 7th day after it, but IL-10 was reduced. During the postoperative period, the newborns of this group had imbalance in the system cytokine, accompanied by clinical complications such as hyperthermia and pulmonary complications. Newborns with transposition of the great arteries who had the surgery using the autologous cord blood, had no significant abnormali­ties in serum levels cytokine before the surgery. The 1st day after surgery there was an increase in both proinflammatory and antiinflammatory cytokines. Up to 7 days the levels of interleukin gradually decreased. Newborns in this group had no postoperative complications, had an adequate immune response to the operation.

Keywords: cord blood, transposition of great vessels, TNF-a,IL-1B, IL-6, IL-8 IL-10.

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